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Echocardiographic and Electrocardiographic Determinants of Atrial Cardiomyopathy Identify Patients with Atrial Fibrillation at Risk for Left Atrial Thrombogenesis

Objective: Atrial cardiomyopathy (ACM) is associated with development of AF, left atrial (LA) thrombogenesis, and stroke. Diagnosis of ACM is feasible using both echocardiographic LA strain imaging and measurement of the amplified p-wave duration (APWD) in digital 12-lead-ECG. We sought to determine...

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Autores principales: Huang, Taiyuan, Patrick, Schurr, Mayer, Louisa Katharina, Müller-Edenborn, Björn, Eichenlaub, Martin, Allgeier, Martin, Allgeier, Jürgen, Lehrmann, Heiko, Ahlgrim, Christoph, Bohnen, Marius, Schoechlin, Simon, Trenk, Dietmar, Jander, Nikolaus, Neumann, Franz Josef, Arentz, Thomas, Jadidi, Amir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8911088/
https://www.ncbi.nlm.nih.gov/pubmed/35268425
http://dx.doi.org/10.3390/jcm11051332
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author Huang, Taiyuan
Patrick, Schurr
Mayer, Louisa Katharina
Müller-Edenborn, Björn
Eichenlaub, Martin
Allgeier, Martin
Allgeier, Jürgen
Lehrmann, Heiko
Ahlgrim, Christoph
Bohnen, Marius
Schoechlin, Simon
Trenk, Dietmar
Jander, Nikolaus
Neumann, Franz Josef
Arentz, Thomas
Jadidi, Amir
author_facet Huang, Taiyuan
Patrick, Schurr
Mayer, Louisa Katharina
Müller-Edenborn, Björn
Eichenlaub, Martin
Allgeier, Martin
Allgeier, Jürgen
Lehrmann, Heiko
Ahlgrim, Christoph
Bohnen, Marius
Schoechlin, Simon
Trenk, Dietmar
Jander, Nikolaus
Neumann, Franz Josef
Arentz, Thomas
Jadidi, Amir
author_sort Huang, Taiyuan
collection PubMed
description Objective: Atrial cardiomyopathy (ACM) is associated with development of AF, left atrial (LA) thrombogenesis, and stroke. Diagnosis of ACM is feasible using both echocardiographic LA strain imaging and measurement of the amplified p-wave duration (APWD) in digital 12-lead-ECG. We sought to determine the thresholds of LA global longitudinal strain (LA-GLS) and APWD that identify patients with AF at risk for LA appendage (LAA) thrombogenesis. Methods: One hundred and twenty-eight patients with a history of AF were included. Left atrial appendage maximal flow velocity (LAA-Vel, in TEE), LA-GLS (TTE), and APWD (digital 12-lead-ECG) were measured in all patients. ROC analysis was performed for each method to determine the thresholds for LA-GLS and the APWD, enabling diagnosis of patients with LAA-thrombus. Results: Significant differences in LA-GLS were found during both rhythms (SR and AF) between the thrombus group and control group: LA-GLS in SR: 14.3 ± 7.4% vs. 24.6 ± 9.0%, p < 0.001 and in AF: 11.4 ± 4.2% vs. 16.1 ± 5.0%, p = 0.045. ROC analysis revealed a threshold of 17.45% for the entire cohort (AUC 0.82, sensitivity: 84.6%, specificity: 63.6%, Negative Predictive Value (NPV): 94.3%) with additional rhythm-specific thresholds: 19.1% in SR and 13.9% in AF, and a threshold of 165 ms for APWD (AUC 0.90, sensitivity: 88.5%, specificity: 75.5%, NPV: 96.2%) as optimal discriminators of LAA-thrombus. Moreover, both LA-GLS and APWD correlated well with the established contractile LA-parameter LAA-Vel in TEE (r = 0.39, p < 0.001 and r = −0.39, p < 0.001, respectively). Conclusion: LA-GLS and APWD are valuable diagnostic predictors of left atrial thrombogenesis in patients with AF.
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spelling pubmed-89110882022-03-11 Echocardiographic and Electrocardiographic Determinants of Atrial Cardiomyopathy Identify Patients with Atrial Fibrillation at Risk for Left Atrial Thrombogenesis Huang, Taiyuan Patrick, Schurr Mayer, Louisa Katharina Müller-Edenborn, Björn Eichenlaub, Martin Allgeier, Martin Allgeier, Jürgen Lehrmann, Heiko Ahlgrim, Christoph Bohnen, Marius Schoechlin, Simon Trenk, Dietmar Jander, Nikolaus Neumann, Franz Josef Arentz, Thomas Jadidi, Amir J Clin Med Article Objective: Atrial cardiomyopathy (ACM) is associated with development of AF, left atrial (LA) thrombogenesis, and stroke. Diagnosis of ACM is feasible using both echocardiographic LA strain imaging and measurement of the amplified p-wave duration (APWD) in digital 12-lead-ECG. We sought to determine the thresholds of LA global longitudinal strain (LA-GLS) and APWD that identify patients with AF at risk for LA appendage (LAA) thrombogenesis. Methods: One hundred and twenty-eight patients with a history of AF were included. Left atrial appendage maximal flow velocity (LAA-Vel, in TEE), LA-GLS (TTE), and APWD (digital 12-lead-ECG) were measured in all patients. ROC analysis was performed for each method to determine the thresholds for LA-GLS and the APWD, enabling diagnosis of patients with LAA-thrombus. Results: Significant differences in LA-GLS were found during both rhythms (SR and AF) between the thrombus group and control group: LA-GLS in SR: 14.3 ± 7.4% vs. 24.6 ± 9.0%, p < 0.001 and in AF: 11.4 ± 4.2% vs. 16.1 ± 5.0%, p = 0.045. ROC analysis revealed a threshold of 17.45% for the entire cohort (AUC 0.82, sensitivity: 84.6%, specificity: 63.6%, Negative Predictive Value (NPV): 94.3%) with additional rhythm-specific thresholds: 19.1% in SR and 13.9% in AF, and a threshold of 165 ms for APWD (AUC 0.90, sensitivity: 88.5%, specificity: 75.5%, NPV: 96.2%) as optimal discriminators of LAA-thrombus. Moreover, both LA-GLS and APWD correlated well with the established contractile LA-parameter LAA-Vel in TEE (r = 0.39, p < 0.001 and r = −0.39, p < 0.001, respectively). Conclusion: LA-GLS and APWD are valuable diagnostic predictors of left atrial thrombogenesis in patients with AF. MDPI 2022-02-28 /pmc/articles/PMC8911088/ /pubmed/35268425 http://dx.doi.org/10.3390/jcm11051332 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Huang, Taiyuan
Patrick, Schurr
Mayer, Louisa Katharina
Müller-Edenborn, Björn
Eichenlaub, Martin
Allgeier, Martin
Allgeier, Jürgen
Lehrmann, Heiko
Ahlgrim, Christoph
Bohnen, Marius
Schoechlin, Simon
Trenk, Dietmar
Jander, Nikolaus
Neumann, Franz Josef
Arentz, Thomas
Jadidi, Amir
Echocardiographic and Electrocardiographic Determinants of Atrial Cardiomyopathy Identify Patients with Atrial Fibrillation at Risk for Left Atrial Thrombogenesis
title Echocardiographic and Electrocardiographic Determinants of Atrial Cardiomyopathy Identify Patients with Atrial Fibrillation at Risk for Left Atrial Thrombogenesis
title_full Echocardiographic and Electrocardiographic Determinants of Atrial Cardiomyopathy Identify Patients with Atrial Fibrillation at Risk for Left Atrial Thrombogenesis
title_fullStr Echocardiographic and Electrocardiographic Determinants of Atrial Cardiomyopathy Identify Patients with Atrial Fibrillation at Risk for Left Atrial Thrombogenesis
title_full_unstemmed Echocardiographic and Electrocardiographic Determinants of Atrial Cardiomyopathy Identify Patients with Atrial Fibrillation at Risk for Left Atrial Thrombogenesis
title_short Echocardiographic and Electrocardiographic Determinants of Atrial Cardiomyopathy Identify Patients with Atrial Fibrillation at Risk for Left Atrial Thrombogenesis
title_sort echocardiographic and electrocardiographic determinants of atrial cardiomyopathy identify patients with atrial fibrillation at risk for left atrial thrombogenesis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8911088/
https://www.ncbi.nlm.nih.gov/pubmed/35268425
http://dx.doi.org/10.3390/jcm11051332
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