Cargando…

Effect of Parathyroidectomy on Metabolic Homeostasis in Primary Hyperparathyroidism

Background: The benefits of parathyroidectomy on cardiovascular risk in primary hyperparathyroidism (PHPT) are controversial. This monocentric, observational, prospective study aimed to assess the effects of parathyroidectomy on glucose and lipid metabolism in classic or mild PHPT. Methods: Patients...

Descripción completa

Detalles Bibliográficos
Autores principales: Frey, Samuel, Bourgade, Raphaël, Le May, Cédric, Croyal, Mikaël, Bigot-Corbel, Edith, Renaud-Moreau, Nelly, Wargny, Matthieu, Caillard, Cécile, Mirallié, Eric, Cariou, Bertrand, Blanchard, Claire
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8911089/
https://www.ncbi.nlm.nih.gov/pubmed/35268464
http://dx.doi.org/10.3390/jcm11051373
_version_ 1784666693657690112
author Frey, Samuel
Bourgade, Raphaël
Le May, Cédric
Croyal, Mikaël
Bigot-Corbel, Edith
Renaud-Moreau, Nelly
Wargny, Matthieu
Caillard, Cécile
Mirallié, Eric
Cariou, Bertrand
Blanchard, Claire
author_facet Frey, Samuel
Bourgade, Raphaël
Le May, Cédric
Croyal, Mikaël
Bigot-Corbel, Edith
Renaud-Moreau, Nelly
Wargny, Matthieu
Caillard, Cécile
Mirallié, Eric
Cariou, Bertrand
Blanchard, Claire
author_sort Frey, Samuel
collection PubMed
description Background: The benefits of parathyroidectomy on cardiovascular risk in primary hyperparathyroidism (PHPT) are controversial. This monocentric, observational, prospective study aimed to assess the effects of parathyroidectomy on glucose and lipid metabolism in classic or mild PHPT. Methods: Patients who underwent parathyroidectomy for classic (calcemia >2.85 mmol/L) or mild PHPT (calcemia ≤2.85 mmol/L) between 2016 and 2019 were included. A metabolic assessment was performed before and 1 year after parathyroidectomy. Patients with a history of diabetes were excluded. Results: Nineteen patients had classic and 120 had mild PHPT. Ninety-five percent were normocalcemic 6 months after surgery. Fasting plasma glucose and insulin levels decreased after parathyroidectomy in patients with mild PHPT (p < 0.001). HOMA-IR decreased after surgery in the overall population (p < 0.001), while plasma adiponectin concentrations increased in patients with both classic (p = 0.005) and mild PHPT (p < 0.001). Plasma triglyceride levels decreased significantly only in patients with classic PHPT (p = 0.021). Plasma PCSK9 levels decreased in patients with mild PHPT (p < 0.001). Conclusions: Parathyroidectomy for PHPT improves insulin resistance and decreases plasma triglyceride levels in classic PHPT and plasma PCSK9 levels in mild PHPT. Further studies are needed to better characterize the consequences of such metabolic risk factors’ improvements on cardiovascular events.
format Online
Article
Text
id pubmed-8911089
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-89110892022-03-11 Effect of Parathyroidectomy on Metabolic Homeostasis in Primary Hyperparathyroidism Frey, Samuel Bourgade, Raphaël Le May, Cédric Croyal, Mikaël Bigot-Corbel, Edith Renaud-Moreau, Nelly Wargny, Matthieu Caillard, Cécile Mirallié, Eric Cariou, Bertrand Blanchard, Claire J Clin Med Article Background: The benefits of parathyroidectomy on cardiovascular risk in primary hyperparathyroidism (PHPT) are controversial. This monocentric, observational, prospective study aimed to assess the effects of parathyroidectomy on glucose and lipid metabolism in classic or mild PHPT. Methods: Patients who underwent parathyroidectomy for classic (calcemia >2.85 mmol/L) or mild PHPT (calcemia ≤2.85 mmol/L) between 2016 and 2019 were included. A metabolic assessment was performed before and 1 year after parathyroidectomy. Patients with a history of diabetes were excluded. Results: Nineteen patients had classic and 120 had mild PHPT. Ninety-five percent were normocalcemic 6 months after surgery. Fasting plasma glucose and insulin levels decreased after parathyroidectomy in patients with mild PHPT (p < 0.001). HOMA-IR decreased after surgery in the overall population (p < 0.001), while plasma adiponectin concentrations increased in patients with both classic (p = 0.005) and mild PHPT (p < 0.001). Plasma triglyceride levels decreased significantly only in patients with classic PHPT (p = 0.021). Plasma PCSK9 levels decreased in patients with mild PHPT (p < 0.001). Conclusions: Parathyroidectomy for PHPT improves insulin resistance and decreases plasma triglyceride levels in classic PHPT and plasma PCSK9 levels in mild PHPT. Further studies are needed to better characterize the consequences of such metabolic risk factors’ improvements on cardiovascular events. MDPI 2022-03-02 /pmc/articles/PMC8911089/ /pubmed/35268464 http://dx.doi.org/10.3390/jcm11051373 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Frey, Samuel
Bourgade, Raphaël
Le May, Cédric
Croyal, Mikaël
Bigot-Corbel, Edith
Renaud-Moreau, Nelly
Wargny, Matthieu
Caillard, Cécile
Mirallié, Eric
Cariou, Bertrand
Blanchard, Claire
Effect of Parathyroidectomy on Metabolic Homeostasis in Primary Hyperparathyroidism
title Effect of Parathyroidectomy on Metabolic Homeostasis in Primary Hyperparathyroidism
title_full Effect of Parathyroidectomy on Metabolic Homeostasis in Primary Hyperparathyroidism
title_fullStr Effect of Parathyroidectomy on Metabolic Homeostasis in Primary Hyperparathyroidism
title_full_unstemmed Effect of Parathyroidectomy on Metabolic Homeostasis in Primary Hyperparathyroidism
title_short Effect of Parathyroidectomy on Metabolic Homeostasis in Primary Hyperparathyroidism
title_sort effect of parathyroidectomy on metabolic homeostasis in primary hyperparathyroidism
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8911089/
https://www.ncbi.nlm.nih.gov/pubmed/35268464
http://dx.doi.org/10.3390/jcm11051373
work_keys_str_mv AT freysamuel effectofparathyroidectomyonmetabolichomeostasisinprimaryhyperparathyroidism
AT bourgaderaphael effectofparathyroidectomyonmetabolichomeostasisinprimaryhyperparathyroidism
AT lemaycedric effectofparathyroidectomyonmetabolichomeostasisinprimaryhyperparathyroidism
AT croyalmikael effectofparathyroidectomyonmetabolichomeostasisinprimaryhyperparathyroidism
AT bigotcorbeledith effectofparathyroidectomyonmetabolichomeostasisinprimaryhyperparathyroidism
AT renaudmoreaunelly effectofparathyroidectomyonmetabolichomeostasisinprimaryhyperparathyroidism
AT wargnymatthieu effectofparathyroidectomyonmetabolichomeostasisinprimaryhyperparathyroidism
AT caillardcecile effectofparathyroidectomyonmetabolichomeostasisinprimaryhyperparathyroidism
AT mirallieeric effectofparathyroidectomyonmetabolichomeostasisinprimaryhyperparathyroidism
AT carioubertrand effectofparathyroidectomyonmetabolichomeostasisinprimaryhyperparathyroidism
AT blanchardclaire effectofparathyroidectomyonmetabolichomeostasisinprimaryhyperparathyroidism