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The Gut Microbiome, Seleno-Compounds, and Acute Myocardial Infarction

Background: Gut microbiome alterations might be considered a metabolic disorder. However, the relationship between the microbiome and acute myocardial infarction (AMI) has not been properly validated. Methods: The feces of 44 subjects (AMI: 19; control: 25) were collected for fecal genomic DNA extra...

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Autores principales: Chiu, Fu-Chun, Tsai, Chin-Feng, Huang, Pang-Shuo, Shih, Ching-Yu, Tsai, Mong-Hsun, Hwang, Juey-Jen, Wang, Yi-Chih, Chuang, Eric Y., Tsai, Chia-Ti, Chang, Sheng-Nan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8911090/
https://www.ncbi.nlm.nih.gov/pubmed/35268552
http://dx.doi.org/10.3390/jcm11051462
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author Chiu, Fu-Chun
Tsai, Chin-Feng
Huang, Pang-Shuo
Shih, Ching-Yu
Tsai, Mong-Hsun
Hwang, Juey-Jen
Wang, Yi-Chih
Chuang, Eric Y.
Tsai, Chia-Ti
Chang, Sheng-Nan
author_facet Chiu, Fu-Chun
Tsai, Chin-Feng
Huang, Pang-Shuo
Shih, Ching-Yu
Tsai, Mong-Hsun
Hwang, Juey-Jen
Wang, Yi-Chih
Chuang, Eric Y.
Tsai, Chia-Ti
Chang, Sheng-Nan
author_sort Chiu, Fu-Chun
collection PubMed
description Background: Gut microbiome alterations might be considered a metabolic disorder. However, the relationship between the microbiome and acute myocardial infarction (AMI) has not been properly validated. Methods: The feces of 44 subjects (AMI: 19; control: 25) were collected for fecal genomic DNA extraction. The variable region V3–V4 of the 16S rRNA gene was sequenced using the Illumina MiSeq platform. The metabolite amounts were analyzed using the Kyoto Encyclopedia of Genes and Genomes (KEGG) metabolic pathways. Results: The bacteria were more enriched in the AMI group both in the observed operational taxonomic units (OTUs) and faith phylogenetic diversity (PD) (p-value = 0.01 and <0.001 with 95% CI, individually). The Selenomonadales were less enriched in the AMI group at the family, genus, and species levels (all linear discriminant analysis (LDA) scores > 2). Seleno-compounds were more abundant in the AMI group at the family, genus, and species levels (all LDA scores > 2). Conclusions: This is the first study to demonstrate the association of Selenomonadales and seleno-compounds with the occurrence of AMI. Our findings provide an opportunity to identify a novel approach to prevent and treat AMI.
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spelling pubmed-89110902022-03-11 The Gut Microbiome, Seleno-Compounds, and Acute Myocardial Infarction Chiu, Fu-Chun Tsai, Chin-Feng Huang, Pang-Shuo Shih, Ching-Yu Tsai, Mong-Hsun Hwang, Juey-Jen Wang, Yi-Chih Chuang, Eric Y. Tsai, Chia-Ti Chang, Sheng-Nan J Clin Med Article Background: Gut microbiome alterations might be considered a metabolic disorder. However, the relationship between the microbiome and acute myocardial infarction (AMI) has not been properly validated. Methods: The feces of 44 subjects (AMI: 19; control: 25) were collected for fecal genomic DNA extraction. The variable region V3–V4 of the 16S rRNA gene was sequenced using the Illumina MiSeq platform. The metabolite amounts were analyzed using the Kyoto Encyclopedia of Genes and Genomes (KEGG) metabolic pathways. Results: The bacteria were more enriched in the AMI group both in the observed operational taxonomic units (OTUs) and faith phylogenetic diversity (PD) (p-value = 0.01 and <0.001 with 95% CI, individually). The Selenomonadales were less enriched in the AMI group at the family, genus, and species levels (all linear discriminant analysis (LDA) scores > 2). Seleno-compounds were more abundant in the AMI group at the family, genus, and species levels (all LDA scores > 2). Conclusions: This is the first study to demonstrate the association of Selenomonadales and seleno-compounds with the occurrence of AMI. Our findings provide an opportunity to identify a novel approach to prevent and treat AMI. MDPI 2022-03-07 /pmc/articles/PMC8911090/ /pubmed/35268552 http://dx.doi.org/10.3390/jcm11051462 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chiu, Fu-Chun
Tsai, Chin-Feng
Huang, Pang-Shuo
Shih, Ching-Yu
Tsai, Mong-Hsun
Hwang, Juey-Jen
Wang, Yi-Chih
Chuang, Eric Y.
Tsai, Chia-Ti
Chang, Sheng-Nan
The Gut Microbiome, Seleno-Compounds, and Acute Myocardial Infarction
title The Gut Microbiome, Seleno-Compounds, and Acute Myocardial Infarction
title_full The Gut Microbiome, Seleno-Compounds, and Acute Myocardial Infarction
title_fullStr The Gut Microbiome, Seleno-Compounds, and Acute Myocardial Infarction
title_full_unstemmed The Gut Microbiome, Seleno-Compounds, and Acute Myocardial Infarction
title_short The Gut Microbiome, Seleno-Compounds, and Acute Myocardial Infarction
title_sort gut microbiome, seleno-compounds, and acute myocardial infarction
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8911090/
https://www.ncbi.nlm.nih.gov/pubmed/35268552
http://dx.doi.org/10.3390/jcm11051462
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