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The Gut Microbiome, Seleno-Compounds, and Acute Myocardial Infarction
Background: Gut microbiome alterations might be considered a metabolic disorder. However, the relationship between the microbiome and acute myocardial infarction (AMI) has not been properly validated. Methods: The feces of 44 subjects (AMI: 19; control: 25) were collected for fecal genomic DNA extra...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8911090/ https://www.ncbi.nlm.nih.gov/pubmed/35268552 http://dx.doi.org/10.3390/jcm11051462 |
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author | Chiu, Fu-Chun Tsai, Chin-Feng Huang, Pang-Shuo Shih, Ching-Yu Tsai, Mong-Hsun Hwang, Juey-Jen Wang, Yi-Chih Chuang, Eric Y. Tsai, Chia-Ti Chang, Sheng-Nan |
author_facet | Chiu, Fu-Chun Tsai, Chin-Feng Huang, Pang-Shuo Shih, Ching-Yu Tsai, Mong-Hsun Hwang, Juey-Jen Wang, Yi-Chih Chuang, Eric Y. Tsai, Chia-Ti Chang, Sheng-Nan |
author_sort | Chiu, Fu-Chun |
collection | PubMed |
description | Background: Gut microbiome alterations might be considered a metabolic disorder. However, the relationship between the microbiome and acute myocardial infarction (AMI) has not been properly validated. Methods: The feces of 44 subjects (AMI: 19; control: 25) were collected for fecal genomic DNA extraction. The variable region V3–V4 of the 16S rRNA gene was sequenced using the Illumina MiSeq platform. The metabolite amounts were analyzed using the Kyoto Encyclopedia of Genes and Genomes (KEGG) metabolic pathways. Results: The bacteria were more enriched in the AMI group both in the observed operational taxonomic units (OTUs) and faith phylogenetic diversity (PD) (p-value = 0.01 and <0.001 with 95% CI, individually). The Selenomonadales were less enriched in the AMI group at the family, genus, and species levels (all linear discriminant analysis (LDA) scores > 2). Seleno-compounds were more abundant in the AMI group at the family, genus, and species levels (all LDA scores > 2). Conclusions: This is the first study to demonstrate the association of Selenomonadales and seleno-compounds with the occurrence of AMI. Our findings provide an opportunity to identify a novel approach to prevent and treat AMI. |
format | Online Article Text |
id | pubmed-8911090 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-89110902022-03-11 The Gut Microbiome, Seleno-Compounds, and Acute Myocardial Infarction Chiu, Fu-Chun Tsai, Chin-Feng Huang, Pang-Shuo Shih, Ching-Yu Tsai, Mong-Hsun Hwang, Juey-Jen Wang, Yi-Chih Chuang, Eric Y. Tsai, Chia-Ti Chang, Sheng-Nan J Clin Med Article Background: Gut microbiome alterations might be considered a metabolic disorder. However, the relationship between the microbiome and acute myocardial infarction (AMI) has not been properly validated. Methods: The feces of 44 subjects (AMI: 19; control: 25) were collected for fecal genomic DNA extraction. The variable region V3–V4 of the 16S rRNA gene was sequenced using the Illumina MiSeq platform. The metabolite amounts were analyzed using the Kyoto Encyclopedia of Genes and Genomes (KEGG) metabolic pathways. Results: The bacteria were more enriched in the AMI group both in the observed operational taxonomic units (OTUs) and faith phylogenetic diversity (PD) (p-value = 0.01 and <0.001 with 95% CI, individually). The Selenomonadales were less enriched in the AMI group at the family, genus, and species levels (all linear discriminant analysis (LDA) scores > 2). Seleno-compounds were more abundant in the AMI group at the family, genus, and species levels (all LDA scores > 2). Conclusions: This is the first study to demonstrate the association of Selenomonadales and seleno-compounds with the occurrence of AMI. Our findings provide an opportunity to identify a novel approach to prevent and treat AMI. MDPI 2022-03-07 /pmc/articles/PMC8911090/ /pubmed/35268552 http://dx.doi.org/10.3390/jcm11051462 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Chiu, Fu-Chun Tsai, Chin-Feng Huang, Pang-Shuo Shih, Ching-Yu Tsai, Mong-Hsun Hwang, Juey-Jen Wang, Yi-Chih Chuang, Eric Y. Tsai, Chia-Ti Chang, Sheng-Nan The Gut Microbiome, Seleno-Compounds, and Acute Myocardial Infarction |
title | The Gut Microbiome, Seleno-Compounds, and Acute Myocardial Infarction |
title_full | The Gut Microbiome, Seleno-Compounds, and Acute Myocardial Infarction |
title_fullStr | The Gut Microbiome, Seleno-Compounds, and Acute Myocardial Infarction |
title_full_unstemmed | The Gut Microbiome, Seleno-Compounds, and Acute Myocardial Infarction |
title_short | The Gut Microbiome, Seleno-Compounds, and Acute Myocardial Infarction |
title_sort | gut microbiome, seleno-compounds, and acute myocardial infarction |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8911090/ https://www.ncbi.nlm.nih.gov/pubmed/35268552 http://dx.doi.org/10.3390/jcm11051462 |
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