Cargando…

Comparative Analysis of Exo- and Endonuclease Activities of APE1-like Enzymes

Apurinic/apyrimidinic (AP)-endonucleases are multifunctional enzymes that are required for cell viability. AP-endonucleases incise DNA 5′ to an AP-site; can recognize and process some damaged nucleosides; and possess 3′-phosphodiesterase, 3′-phosphatase, and endoribonuclease activities. To elucidate...

Descripción completa

Detalles Bibliográficos
Autores principales:	Davletgildeeva, Anastasiia T., Kuznetsova, Alexandra A., Novopashina, Darya S., Ishchenko, Alexander A., Saparbaev, Murat, Fedorova, Olga S., Kuznetsov, Nikita A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8911113/ https://www.ncbi.nlm.nih.gov/pubmed/35270011 http://dx.doi.org/10.3390/ijms23052869

Ejemplares similares

The Enigma of Substrate Recognition and Catalytic Efficiency of APE1-Like Enzymes
por: Davletgildeeva, Anastasiia T., et al.
Publicado: (2021)

Activity of Human Apurinic/Apyrimidinic Endonuclease APE1 Toward Damaged DNA and Native RNA With Non-canonical Structures
por: Davletgildeeva, Anastasia T., et al.
Publicado: (2020)

Common Kinetic Mechanism of Abasic Site Recognition by Structurally Different Apurinic/Apyrimidinic Endonucleases
por: Kuznetsova, Alexandra A., et al.
Publicado: (2021)

Modulation of the Apurinic/Apyrimidinic Endonuclease Activity of Human APE1 and of Its Natural Polymorphic Variants by Base Excision Repair Proteins
por: Kladova, Olga A., et al.
Publicado: (2020)

The Kinetic Mechanism of 3′-5′ Exonucleolytic Activity of AP Endonuclease Nfo from E. coli
por: Senchurova, Svetlana I., et al.
Publicado: (2022)

Kinetic Features of 3′-5′ Exonuclease Activity of Human AP-Endonuclease APE1
por: Kuznetsova, Alexandra A., et al.
Publicado: (2018)

Effect of the Substrate Structure and Metal Ions on the Hydrolysis of Undamaged RNA by Human AP Endonuclease APE1
por: Kuznetsova, A. A., et al.
Publicado: (2020)

Kinetic Features of 3′–5′–Exonuclease Activity of Apurinic/Apyrimidinic Endonuclease Apn2 from Saccharomyces cerevisiae
por: Kuznetsova, Aleksandra A., et al.
Publicado: (2022)

Individual Contributions of Amido Acid Residues Tyr122, Ile168, and Asp173 to the Activity and Substrate Specificity of Human DNA Dioxygenase ABH2
por: Davletgildeeva, Anastasiia T., et al.
Publicado: (2023)

Inner Amino Acid Contacts Are Key Factors of Multistage Structural Rearrangements of DNA and Affect Substrate Specificity of Apurinic/Apyrimidinic Endonuclease APE1
por: Bulygin, Anatoly A., et al.
Publicado: (2023)

The Role of Active-Site Plasticity in Damaged-Nucleotide Recognition by Human Apurinic/Apyrimidinic Endonuclease APE1
por: Bulygin, Anatoly A., et al.
Publicado: (2020)

Insights into Mechanisms of Damage Recognition and Catalysis by APE1-like Enzymes
por: Bulygin, Anatoly A., et al.
Publicado: (2022)

Substrate specificity of human apurinic/apyrimidinic endonuclease APE1 in the nucleotide incision repair pathway
por: Kuznetsova, Alexandra A, et al.
Publicado: (2018)

Lys98 Substitution in Human AP Endonuclease 1 Affects the Kinetic Mechanism of Enzyme Action in Base Excision and Nucleotide Incision Repair Pathways
por: Timofeyeva, Nadezhda A., et al.
Publicado: (2011)

Mutational and Kinetic Analysis of APE1 Endoribonuclease Activity
por: Kuznetsova, A. A., et al.
Publicado: (2021)

Genetic and Biochemical Characterization of Human AP Endonuclease 1 Mutants Deficient in Nucleotide Incision Repair Activity
por: Gelin, Aurore, et al.
Publicado: (2010)

Mutational and Kinetic Analysis of Lesion Recognition by Escherichia coli Endonuclease VIII
por: Kladova, Olga A., et al.
Publicado: (2017)

African swine fever virus AP endonuclease is a redox-sensitive enzyme that repairs alkylating and oxidative damage to DNA
por: Redrejo-Rodríguez, Modesto, et al.
Publicado: (2009)

Cloning and Characterization of a Wheat Homologue of Apurinic/Apyrimidinic Endonuclease Ape1L
por: Joldybayeva, Botagoz, et al.
Publicado: (2014)

Conformational Dynamics of Human ALKBH2 Dioxygenase in the Course of DNA Repair as Revealed by Stopped-Flow Fluorescence Spectroscopy
por: Kanazhevskaya, Lyubov Yu., et al.
Publicado: (2022)

The Impact of Human DNA Glycosylases on the Activity of DNA Polymerase β toward Various Base Excision Repair Intermediates
por: Bakman, Artemiy S., et al.
Publicado: (2023)

Characterization of biochemical properties of an apurinic/apyrimidinic endonuclease from Helicobacter pylori
por: Turgimbayeva, Aigerim, et al.
Publicado: (2018)

Abasic site–peptide cross-links are blocking lesions repaired by AP endonucleases
por: Yudkina, Anna V, et al.
Publicado: (2023)

Kinetic Analysis of the Interaction of Nicking Endonuclease BspD6I with DNA
por: Abrosimova, Liudmila A., et al.
Publicado: (2021)

Thermodynamics of Damaged DNA Binding and Catalysis by Human AP Endonuclease 1
por: Miroshnikova, A. D., et al.
Publicado: (2016)

Lesion Recognition and Cleavage of Damage-Containing Quadruplexes and Bulged Structures by DNA Glycosylases
por: Kuznetsova, Alexandra A., et al.
Publicado: (2020)

Thermodynamics of the DNA Repair Process by Endonuclease VIII
por: Kladova, O. A., et al.
Publicado: (2019)

Data on PAGE analysis and MD simulation for the interaction of endonuclease Apn1 from Saccharomyces cerevisiae with DNA substrates containing 5,6-dihydrouracyl and 2-aminopurine
por: Dyakonova, Elena S., et al.
Publicado: (2018)

Structural and Molecular Kinetic Features of Activities of DNA Polymerases
por: Kuznetsova, Aleksandra A., et al.
Publicado: (2022)

Correction: Highly Mutagenic Exocyclic DNA Adducts Are Substrates for the Human Nucleotide Incision Repair Pathway
por: Prorok, Paulina, et al.
Publicado: (2013)

Highly Mutagenic Exocyclic DNA Adducts Are Substrates for the Human Nucleotide Incision Repair Pathway
por: Prorok, Paulina, et al.
Publicado: (2012)

The Activity of Natural Polymorphic Variants of Human DNA Polymerase β Having an Amino Acid Substitution in the Transferase Domain
por: Kladova, Olga A., et al.
Publicado: (2023)

Identification and Characterization of Inhibitors of Human Apurinic/apyrimidinic Endonuclease APE1
por: Simeonov, Anton, et al.
Publicado: (2009)

Human Polβ Natural Polymorphic Variants G118V and R149I Affects Substate Binding and Catalysis
por: Kladova, Olga A., et al.
Publicado: (2023)

Structural and Functional Differences between Homologous Bacterial Ribonucleases
por: Ulyanova, Vera, et al.
Publicado: (2022)

Cas9 exo-endonuclease eliminates chromosomal translocations during genome editing
por: Yin, Jianhang, et al.
Publicado: (2022)

Thermodynamics of the DNA Damage Repair Steps of Human 8-Oxoguanine DNA Glycosylase
por: Kuznetsov, Nikita A., et al.
Publicado: (2014)

Analysis of nuclear transport signals in the human apurinic/apyrimidinic endonuclease (APE1/Ref1)
por: Jackson, Elias B., et al.
Publicado: (2005)

The Methanothermobacter thermautotrophicus ExoIII homologue Mth212 is a DNA uridine endonuclease
por: Georg, Jens, et al.
Publicado: (2006)

The structure of Escherichia coli ExoIX—implications for DNA binding and catalysis in flap endonucleases
por: Anstey-Gilbert, Christopher S., et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_6fc4k3o2c4hf3nbgvdlmbmvp4k