Cargando…

Choroidal Thickness and Primary Open-Angle Glaucoma—A Narrative Review

The choroid provides the majority of blood flow to the ocular tissues and structures that facilitate the processes of retinal metabolism responsible for vision. Specifically, the choriocapillaris provides a structural network of small blood vessels that supplies the retinal ganglion cells and deep o...

Descripción completa

Detalles Bibliográficos
Autores principales: Verticchio Vercellin, Alice, Harris, Alon, Stoner, Ari M., Oddone, Francesco, Mendoza, Kristen Ann, Siesky, Brent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8911149/
https://www.ncbi.nlm.nih.gov/pubmed/35268300
http://dx.doi.org/10.3390/jcm11051209
_version_ 1784666713251381248
author Verticchio Vercellin, Alice
Harris, Alon
Stoner, Ari M.
Oddone, Francesco
Mendoza, Kristen Ann
Siesky, Brent
author_facet Verticchio Vercellin, Alice
Harris, Alon
Stoner, Ari M.
Oddone, Francesco
Mendoza, Kristen Ann
Siesky, Brent
author_sort Verticchio Vercellin, Alice
collection PubMed
description The choroid provides the majority of blood flow to the ocular tissues and structures that facilitate the processes of retinal metabolism responsible for vision. Specifically, the choriocapillaris provides a structural network of small blood vessels that supplies the retinal ganglion cells and deep ocular tissues. Similar to retinal nerve fiber layer thickness, choroidal thickness (CT) has been suggested to represent a quantifiable health biomarker for choroidal tissues. Glaucoma is a disease with vascular contributions in its onset and progression. Despite its importance in maintaining ocular structure and vascular functionality, clinical assessments of choroidal tissues have been historically challenged by the inaccessibility of CT biomarker targets. The development of optical coherence tomography angiography and enhanced depth imaging created a framework for assessing CT and investigating its relationship to glaucomatous optic neuropathy onset and progression. Pilot studies on CT in glaucoma are conflicting—with those both in support of, and against, its clinical utility. Complicating the data are highly customized analysis methods, small sample sizes, heterogeneous patient groups, and a lack of properly designed controlled studies with CT as a primary outcome. Herein, we review the available data on CT and critically discuss its potential relevance and limitations in glaucoma disease management.
format Online
Article
Text
id pubmed-8911149
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-89111492022-03-11 Choroidal Thickness and Primary Open-Angle Glaucoma—A Narrative Review Verticchio Vercellin, Alice Harris, Alon Stoner, Ari M. Oddone, Francesco Mendoza, Kristen Ann Siesky, Brent J Clin Med Review The choroid provides the majority of blood flow to the ocular tissues and structures that facilitate the processes of retinal metabolism responsible for vision. Specifically, the choriocapillaris provides a structural network of small blood vessels that supplies the retinal ganglion cells and deep ocular tissues. Similar to retinal nerve fiber layer thickness, choroidal thickness (CT) has been suggested to represent a quantifiable health biomarker for choroidal tissues. Glaucoma is a disease with vascular contributions in its onset and progression. Despite its importance in maintaining ocular structure and vascular functionality, clinical assessments of choroidal tissues have been historically challenged by the inaccessibility of CT biomarker targets. The development of optical coherence tomography angiography and enhanced depth imaging created a framework for assessing CT and investigating its relationship to glaucomatous optic neuropathy onset and progression. Pilot studies on CT in glaucoma are conflicting—with those both in support of, and against, its clinical utility. Complicating the data are highly customized analysis methods, small sample sizes, heterogeneous patient groups, and a lack of properly designed controlled studies with CT as a primary outcome. Herein, we review the available data on CT and critically discuss its potential relevance and limitations in glaucoma disease management. MDPI 2022-02-23 /pmc/articles/PMC8911149/ /pubmed/35268300 http://dx.doi.org/10.3390/jcm11051209 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Verticchio Vercellin, Alice
Harris, Alon
Stoner, Ari M.
Oddone, Francesco
Mendoza, Kristen Ann
Siesky, Brent
Choroidal Thickness and Primary Open-Angle Glaucoma—A Narrative Review
title Choroidal Thickness and Primary Open-Angle Glaucoma—A Narrative Review
title_full Choroidal Thickness and Primary Open-Angle Glaucoma—A Narrative Review
title_fullStr Choroidal Thickness and Primary Open-Angle Glaucoma—A Narrative Review
title_full_unstemmed Choroidal Thickness and Primary Open-Angle Glaucoma—A Narrative Review
title_short Choroidal Thickness and Primary Open-Angle Glaucoma—A Narrative Review
title_sort choroidal thickness and primary open-angle glaucoma—a narrative review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8911149/
https://www.ncbi.nlm.nih.gov/pubmed/35268300
http://dx.doi.org/10.3390/jcm11051209
work_keys_str_mv AT verticchiovercellinalice choroidalthicknessandprimaryopenangleglaucomaanarrativereview
AT harrisalon choroidalthicknessandprimaryopenangleglaucomaanarrativereview
AT stonerarim choroidalthicknessandprimaryopenangleglaucomaanarrativereview
AT oddonefrancesco choroidalthicknessandprimaryopenangleglaucomaanarrativereview
AT mendozakristenann choroidalthicknessandprimaryopenangleglaucomaanarrativereview
AT sieskybrent choroidalthicknessandprimaryopenangleglaucomaanarrativereview