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Abdominal Aortic Calcification and Cardiovascular Outcomes in Chronic Kidney Disease: Findings from KNOW-CKD Study
To investigate the association between abdominal aortic calcification score (AACS) assessed by plain radiograph of the lateral abdomen and the risk of cardiovascular (CV) events in patients with pre-dialysis chronic kidney disease (CKD), a total of 2090 pre-dialysis CKD patients from the Korean Coho...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8911161/ https://www.ncbi.nlm.nih.gov/pubmed/35268249 http://dx.doi.org/10.3390/jcm11051157 |
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author | Suh, Sang Heon Oh, Tae Ryom Choi, Hong Sang Kim, Chang Seong Bae, Eun Hui Oh, Kook-Hwan Lee, Joongyub Oh, Yun Kyu Jung, Ji Yong Ma, Seong Kwon Kim, Soo Wan |
author_facet | Suh, Sang Heon Oh, Tae Ryom Choi, Hong Sang Kim, Chang Seong Bae, Eun Hui Oh, Kook-Hwan Lee, Joongyub Oh, Yun Kyu Jung, Ji Yong Ma, Seong Kwon Kim, Soo Wan |
author_sort | Suh, Sang Heon |
collection | PubMed |
description | To investigate the association between abdominal aortic calcification score (AACS) assessed by plain radiograph of the lateral abdomen and the risk of cardiovascular (CV) events in patients with pre-dialysis chronic kidney disease (CKD), a total of 2090 pre-dialysis CKD patients from the Korean Cohort Study for Outcome in Patients with Chronic Kidney Disease (KNOW-CKD) were categorized by AACS into 0, 1–2, 3–4, 5–6, and ≥7. The primary outcome of the study was the composite CV events, defined as a composite of non-fatal CV events and all-cause death. The risk of composite CV events was significantly higher in the subjects with AACS ≥ 7 (adjusted hazard ratio (HR) 1.888, 95% confidence interval (CI) 1.219 to 2.923), compared to that of the subjects with AACS 0. The risks of fatal and non-fatal CV events (adjusted HR 1.052, 95% CI 1.030 to 1.073) and all-cause death (adjusted HR 1.949, 95% CI 1.073 to 3.539) were also significantly higher in the subjects with AACS ≥ 7. In conclusion, AACS assessed by plain radiograph is independently associated with adverse CV outcomes in patients with pre-dialysis CKD. A simple radiographic examination of the lateral abdomen may help CV risk stratification in this population. |
format | Online Article Text |
id | pubmed-8911161 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-89111612022-03-11 Abdominal Aortic Calcification and Cardiovascular Outcomes in Chronic Kidney Disease: Findings from KNOW-CKD Study Suh, Sang Heon Oh, Tae Ryom Choi, Hong Sang Kim, Chang Seong Bae, Eun Hui Oh, Kook-Hwan Lee, Joongyub Oh, Yun Kyu Jung, Ji Yong Ma, Seong Kwon Kim, Soo Wan J Clin Med Article To investigate the association between abdominal aortic calcification score (AACS) assessed by plain radiograph of the lateral abdomen and the risk of cardiovascular (CV) events in patients with pre-dialysis chronic kidney disease (CKD), a total of 2090 pre-dialysis CKD patients from the Korean Cohort Study for Outcome in Patients with Chronic Kidney Disease (KNOW-CKD) were categorized by AACS into 0, 1–2, 3–4, 5–6, and ≥7. The primary outcome of the study was the composite CV events, defined as a composite of non-fatal CV events and all-cause death. The risk of composite CV events was significantly higher in the subjects with AACS ≥ 7 (adjusted hazard ratio (HR) 1.888, 95% confidence interval (CI) 1.219 to 2.923), compared to that of the subjects with AACS 0. The risks of fatal and non-fatal CV events (adjusted HR 1.052, 95% CI 1.030 to 1.073) and all-cause death (adjusted HR 1.949, 95% CI 1.073 to 3.539) were also significantly higher in the subjects with AACS ≥ 7. In conclusion, AACS assessed by plain radiograph is independently associated with adverse CV outcomes in patients with pre-dialysis CKD. A simple radiographic examination of the lateral abdomen may help CV risk stratification in this population. MDPI 2022-02-22 /pmc/articles/PMC8911161/ /pubmed/35268249 http://dx.doi.org/10.3390/jcm11051157 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Suh, Sang Heon Oh, Tae Ryom Choi, Hong Sang Kim, Chang Seong Bae, Eun Hui Oh, Kook-Hwan Lee, Joongyub Oh, Yun Kyu Jung, Ji Yong Ma, Seong Kwon Kim, Soo Wan Abdominal Aortic Calcification and Cardiovascular Outcomes in Chronic Kidney Disease: Findings from KNOW-CKD Study |
title | Abdominal Aortic Calcification and Cardiovascular Outcomes in Chronic Kidney Disease: Findings from KNOW-CKD Study |
title_full | Abdominal Aortic Calcification and Cardiovascular Outcomes in Chronic Kidney Disease: Findings from KNOW-CKD Study |
title_fullStr | Abdominal Aortic Calcification and Cardiovascular Outcomes in Chronic Kidney Disease: Findings from KNOW-CKD Study |
title_full_unstemmed | Abdominal Aortic Calcification and Cardiovascular Outcomes in Chronic Kidney Disease: Findings from KNOW-CKD Study |
title_short | Abdominal Aortic Calcification and Cardiovascular Outcomes in Chronic Kidney Disease: Findings from KNOW-CKD Study |
title_sort | abdominal aortic calcification and cardiovascular outcomes in chronic kidney disease: findings from know-ckd study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8911161/ https://www.ncbi.nlm.nih.gov/pubmed/35268249 http://dx.doi.org/10.3390/jcm11051157 |
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