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Abdominal Aortic Calcification and Cardiovascular Outcomes in Chronic Kidney Disease: Findings from KNOW-CKD Study

To investigate the association between abdominal aortic calcification score (AACS) assessed by plain radiograph of the lateral abdomen and the risk of cardiovascular (CV) events in patients with pre-dialysis chronic kidney disease (CKD), a total of 2090 pre-dialysis CKD patients from the Korean Coho...

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Autores principales: Suh, Sang Heon, Oh, Tae Ryom, Choi, Hong Sang, Kim, Chang Seong, Bae, Eun Hui, Oh, Kook-Hwan, Lee, Joongyub, Oh, Yun Kyu, Jung, Ji Yong, Ma, Seong Kwon, Kim, Soo Wan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8911161/
https://www.ncbi.nlm.nih.gov/pubmed/35268249
http://dx.doi.org/10.3390/jcm11051157
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author Suh, Sang Heon
Oh, Tae Ryom
Choi, Hong Sang
Kim, Chang Seong
Bae, Eun Hui
Oh, Kook-Hwan
Lee, Joongyub
Oh, Yun Kyu
Jung, Ji Yong
Ma, Seong Kwon
Kim, Soo Wan
author_facet Suh, Sang Heon
Oh, Tae Ryom
Choi, Hong Sang
Kim, Chang Seong
Bae, Eun Hui
Oh, Kook-Hwan
Lee, Joongyub
Oh, Yun Kyu
Jung, Ji Yong
Ma, Seong Kwon
Kim, Soo Wan
author_sort Suh, Sang Heon
collection PubMed
description To investigate the association between abdominal aortic calcification score (AACS) assessed by plain radiograph of the lateral abdomen and the risk of cardiovascular (CV) events in patients with pre-dialysis chronic kidney disease (CKD), a total of 2090 pre-dialysis CKD patients from the Korean Cohort Study for Outcome in Patients with Chronic Kidney Disease (KNOW-CKD) were categorized by AACS into 0, 1–2, 3–4, 5–6, and ≥7. The primary outcome of the study was the composite CV events, defined as a composite of non-fatal CV events and all-cause death. The risk of composite CV events was significantly higher in the subjects with AACS ≥ 7 (adjusted hazard ratio (HR) 1.888, 95% confidence interval (CI) 1.219 to 2.923), compared to that of the subjects with AACS 0. The risks of fatal and non-fatal CV events (adjusted HR 1.052, 95% CI 1.030 to 1.073) and all-cause death (adjusted HR 1.949, 95% CI 1.073 to 3.539) were also significantly higher in the subjects with AACS ≥ 7. In conclusion, AACS assessed by plain radiograph is independently associated with adverse CV outcomes in patients with pre-dialysis CKD. A simple radiographic examination of the lateral abdomen may help CV risk stratification in this population.
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spelling pubmed-89111612022-03-11 Abdominal Aortic Calcification and Cardiovascular Outcomes in Chronic Kidney Disease: Findings from KNOW-CKD Study Suh, Sang Heon Oh, Tae Ryom Choi, Hong Sang Kim, Chang Seong Bae, Eun Hui Oh, Kook-Hwan Lee, Joongyub Oh, Yun Kyu Jung, Ji Yong Ma, Seong Kwon Kim, Soo Wan J Clin Med Article To investigate the association between abdominal aortic calcification score (AACS) assessed by plain radiograph of the lateral abdomen and the risk of cardiovascular (CV) events in patients with pre-dialysis chronic kidney disease (CKD), a total of 2090 pre-dialysis CKD patients from the Korean Cohort Study for Outcome in Patients with Chronic Kidney Disease (KNOW-CKD) were categorized by AACS into 0, 1–2, 3–4, 5–6, and ≥7. The primary outcome of the study was the composite CV events, defined as a composite of non-fatal CV events and all-cause death. The risk of composite CV events was significantly higher in the subjects with AACS ≥ 7 (adjusted hazard ratio (HR) 1.888, 95% confidence interval (CI) 1.219 to 2.923), compared to that of the subjects with AACS 0. The risks of fatal and non-fatal CV events (adjusted HR 1.052, 95% CI 1.030 to 1.073) and all-cause death (adjusted HR 1.949, 95% CI 1.073 to 3.539) were also significantly higher in the subjects with AACS ≥ 7. In conclusion, AACS assessed by plain radiograph is independently associated with adverse CV outcomes in patients with pre-dialysis CKD. A simple radiographic examination of the lateral abdomen may help CV risk stratification in this population. MDPI 2022-02-22 /pmc/articles/PMC8911161/ /pubmed/35268249 http://dx.doi.org/10.3390/jcm11051157 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Suh, Sang Heon
Oh, Tae Ryom
Choi, Hong Sang
Kim, Chang Seong
Bae, Eun Hui
Oh, Kook-Hwan
Lee, Joongyub
Oh, Yun Kyu
Jung, Ji Yong
Ma, Seong Kwon
Kim, Soo Wan
Abdominal Aortic Calcification and Cardiovascular Outcomes in Chronic Kidney Disease: Findings from KNOW-CKD Study
title Abdominal Aortic Calcification and Cardiovascular Outcomes in Chronic Kidney Disease: Findings from KNOW-CKD Study
title_full Abdominal Aortic Calcification and Cardiovascular Outcomes in Chronic Kidney Disease: Findings from KNOW-CKD Study
title_fullStr Abdominal Aortic Calcification and Cardiovascular Outcomes in Chronic Kidney Disease: Findings from KNOW-CKD Study
title_full_unstemmed Abdominal Aortic Calcification and Cardiovascular Outcomes in Chronic Kidney Disease: Findings from KNOW-CKD Study
title_short Abdominal Aortic Calcification and Cardiovascular Outcomes in Chronic Kidney Disease: Findings from KNOW-CKD Study
title_sort abdominal aortic calcification and cardiovascular outcomes in chronic kidney disease: findings from know-ckd study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8911161/
https://www.ncbi.nlm.nih.gov/pubmed/35268249
http://dx.doi.org/10.3390/jcm11051157
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