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Sex-specific differences in early renal impairment associated with arsenic, lead, and cadmium exposure among young adults in Taiwan

Exposure to a single metal has been reported to damage renal function in humans. However, information regarding the association between multiple-metal exposure and markers for early renal impairment in different sexes among the young adult Taiwanese population is scarce. We assessed the association...

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Autores principales: Liao, Kai-Wei, Chien, Ling-Chu, Chen, Yang-Ching, Kao, Ho-Ching
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8911167/
https://www.ncbi.nlm.nih.gov/pubmed/35274206
http://dx.doi.org/10.1007/s11356-022-19521-3
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author Liao, Kai-Wei
Chien, Ling-Chu
Chen, Yang-Ching
Kao, Ho-Ching
author_facet Liao, Kai-Wei
Chien, Ling-Chu
Chen, Yang-Ching
Kao, Ho-Ching
author_sort Liao, Kai-Wei
collection PubMed
description Exposure to a single metal has been reported to damage renal function in humans. However, information regarding the association between multiple-metal exposure and markers for early renal impairment in different sexes among the young adult Taiwanese population is scarce. We assessed the association between exposure to arsenic (As), cadmium (Cd), and lead (Pb), and early renal impairment markers using urinary microalbumin (MA), β2-microglobulin (β2MG), and N-acetyl-beta-D-glucosaminidase (NAG) by analyzing 157 young adults aged 20‒29 years, in Taiwan. Inductively coupled plasma mass spectrometry was used to determine urinary As, Cd, and Pb levels. Regression models were applied to different sex groups. The results showed that after adjusting for potential confounding factors and each metal, urinary Cd levels were significantly positively associated with urinary MA (β = 0.523, 95% CI: 0.147–0.899) and β2MG (β = 1.502, 95% CI: 0.635–2.370) in males. However, the urinary Cd level was significantly positively associated with only urinary NAG (β = 0.161, 95% CI: 0.027–0.296) in females. This study thus indicates that the effect of exposure to metals (especially Cd) on early renal impairment among young adults in Taiwan is sex-specific. Our study results could contribute toward developing early intervention programs for decreasing the incidence of renal dysfunction. Further studies are warranted to confirm our findings and clarify the potential mechanisms involved. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11356-022-19521-3.
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spelling pubmed-89111672022-03-11 Sex-specific differences in early renal impairment associated with arsenic, lead, and cadmium exposure among young adults in Taiwan Liao, Kai-Wei Chien, Ling-Chu Chen, Yang-Ching Kao, Ho-Ching Environ Sci Pollut Res Int Research Article Exposure to a single metal has been reported to damage renal function in humans. However, information regarding the association between multiple-metal exposure and markers for early renal impairment in different sexes among the young adult Taiwanese population is scarce. We assessed the association between exposure to arsenic (As), cadmium (Cd), and lead (Pb), and early renal impairment markers using urinary microalbumin (MA), β2-microglobulin (β2MG), and N-acetyl-beta-D-glucosaminidase (NAG) by analyzing 157 young adults aged 20‒29 years, in Taiwan. Inductively coupled plasma mass spectrometry was used to determine urinary As, Cd, and Pb levels. Regression models were applied to different sex groups. The results showed that after adjusting for potential confounding factors and each metal, urinary Cd levels were significantly positively associated with urinary MA (β = 0.523, 95% CI: 0.147–0.899) and β2MG (β = 1.502, 95% CI: 0.635–2.370) in males. However, the urinary Cd level was significantly positively associated with only urinary NAG (β = 0.161, 95% CI: 0.027–0.296) in females. This study thus indicates that the effect of exposure to metals (especially Cd) on early renal impairment among young adults in Taiwan is sex-specific. Our study results could contribute toward developing early intervention programs for decreasing the incidence of renal dysfunction. Further studies are warranted to confirm our findings and clarify the potential mechanisms involved. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11356-022-19521-3. Springer Berlin Heidelberg 2022-03-10 2022 /pmc/articles/PMC8911167/ /pubmed/35274206 http://dx.doi.org/10.1007/s11356-022-19521-3 Text en © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Research Article
Liao, Kai-Wei
Chien, Ling-Chu
Chen, Yang-Ching
Kao, Ho-Ching
Sex-specific differences in early renal impairment associated with arsenic, lead, and cadmium exposure among young adults in Taiwan
title Sex-specific differences in early renal impairment associated with arsenic, lead, and cadmium exposure among young adults in Taiwan
title_full Sex-specific differences in early renal impairment associated with arsenic, lead, and cadmium exposure among young adults in Taiwan
title_fullStr Sex-specific differences in early renal impairment associated with arsenic, lead, and cadmium exposure among young adults in Taiwan
title_full_unstemmed Sex-specific differences in early renal impairment associated with arsenic, lead, and cadmium exposure among young adults in Taiwan
title_short Sex-specific differences in early renal impairment associated with arsenic, lead, and cadmium exposure among young adults in Taiwan
title_sort sex-specific differences in early renal impairment associated with arsenic, lead, and cadmium exposure among young adults in taiwan
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8911167/
https://www.ncbi.nlm.nih.gov/pubmed/35274206
http://dx.doi.org/10.1007/s11356-022-19521-3
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