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Sex-specific differences in early renal impairment associated with arsenic, lead, and cadmium exposure among young adults in Taiwan
Exposure to a single metal has been reported to damage renal function in humans. However, information regarding the association between multiple-metal exposure and markers for early renal impairment in different sexes among the young adult Taiwanese population is scarce. We assessed the association...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Springer Berlin Heidelberg
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8911167/ https://www.ncbi.nlm.nih.gov/pubmed/35274206 http://dx.doi.org/10.1007/s11356-022-19521-3 |
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author | Liao, Kai-Wei Chien, Ling-Chu Chen, Yang-Ching Kao, Ho-Ching |
author_facet | Liao, Kai-Wei Chien, Ling-Chu Chen, Yang-Ching Kao, Ho-Ching |
author_sort | Liao, Kai-Wei |
collection | PubMed |
description | Exposure to a single metal has been reported to damage renal function in humans. However, information regarding the association between multiple-metal exposure and markers for early renal impairment in different sexes among the young adult Taiwanese population is scarce. We assessed the association between exposure to arsenic (As), cadmium (Cd), and lead (Pb), and early renal impairment markers using urinary microalbumin (MA), β2-microglobulin (β2MG), and N-acetyl-beta-D-glucosaminidase (NAG) by analyzing 157 young adults aged 20‒29 years, in Taiwan. Inductively coupled plasma mass spectrometry was used to determine urinary As, Cd, and Pb levels. Regression models were applied to different sex groups. The results showed that after adjusting for potential confounding factors and each metal, urinary Cd levels were significantly positively associated with urinary MA (β = 0.523, 95% CI: 0.147–0.899) and β2MG (β = 1.502, 95% CI: 0.635–2.370) in males. However, the urinary Cd level was significantly positively associated with only urinary NAG (β = 0.161, 95% CI: 0.027–0.296) in females. This study thus indicates that the effect of exposure to metals (especially Cd) on early renal impairment among young adults in Taiwan is sex-specific. Our study results could contribute toward developing early intervention programs for decreasing the incidence of renal dysfunction. Further studies are warranted to confirm our findings and clarify the potential mechanisms involved. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11356-022-19521-3. |
format | Online Article Text |
id | pubmed-8911167 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-89111672022-03-11 Sex-specific differences in early renal impairment associated with arsenic, lead, and cadmium exposure among young adults in Taiwan Liao, Kai-Wei Chien, Ling-Chu Chen, Yang-Ching Kao, Ho-Ching Environ Sci Pollut Res Int Research Article Exposure to a single metal has been reported to damage renal function in humans. However, information regarding the association between multiple-metal exposure and markers for early renal impairment in different sexes among the young adult Taiwanese population is scarce. We assessed the association between exposure to arsenic (As), cadmium (Cd), and lead (Pb), and early renal impairment markers using urinary microalbumin (MA), β2-microglobulin (β2MG), and N-acetyl-beta-D-glucosaminidase (NAG) by analyzing 157 young adults aged 20‒29 years, in Taiwan. Inductively coupled plasma mass spectrometry was used to determine urinary As, Cd, and Pb levels. Regression models were applied to different sex groups. The results showed that after adjusting for potential confounding factors and each metal, urinary Cd levels were significantly positively associated with urinary MA (β = 0.523, 95% CI: 0.147–0.899) and β2MG (β = 1.502, 95% CI: 0.635–2.370) in males. However, the urinary Cd level was significantly positively associated with only urinary NAG (β = 0.161, 95% CI: 0.027–0.296) in females. This study thus indicates that the effect of exposure to metals (especially Cd) on early renal impairment among young adults in Taiwan is sex-specific. Our study results could contribute toward developing early intervention programs for decreasing the incidence of renal dysfunction. Further studies are warranted to confirm our findings and clarify the potential mechanisms involved. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11356-022-19521-3. Springer Berlin Heidelberg 2022-03-10 2022 /pmc/articles/PMC8911167/ /pubmed/35274206 http://dx.doi.org/10.1007/s11356-022-19521-3 Text en © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Research Article Liao, Kai-Wei Chien, Ling-Chu Chen, Yang-Ching Kao, Ho-Ching Sex-specific differences in early renal impairment associated with arsenic, lead, and cadmium exposure among young adults in Taiwan |
title | Sex-specific differences in early renal impairment associated with arsenic, lead, and cadmium exposure among young adults in Taiwan |
title_full | Sex-specific differences in early renal impairment associated with arsenic, lead, and cadmium exposure among young adults in Taiwan |
title_fullStr | Sex-specific differences in early renal impairment associated with arsenic, lead, and cadmium exposure among young adults in Taiwan |
title_full_unstemmed | Sex-specific differences in early renal impairment associated with arsenic, lead, and cadmium exposure among young adults in Taiwan |
title_short | Sex-specific differences in early renal impairment associated with arsenic, lead, and cadmium exposure among young adults in Taiwan |
title_sort | sex-specific differences in early renal impairment associated with arsenic, lead, and cadmium exposure among young adults in taiwan |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8911167/ https://www.ncbi.nlm.nih.gov/pubmed/35274206 http://dx.doi.org/10.1007/s11356-022-19521-3 |
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