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Changes in Exercise Capacity and Ventricular Function in Arrhythmogenic Right Ventricular Cardiomyopathy: The Impact of Sports Restriction during Follow-Up

(1) Background: Physical exercise has been suggested to promote disease progression in patients with arrhythmogenic right ventricular cardiomyopathy (ARVC). We aimed to investigate the exercise performance and ventricular function of ARVC patients during follow-up, while taking into account their ad...

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Autores principales: Costa, Sarah, Koch, Kristina, Gasperetti, Alessio, Akdis, Deniz, Brunckhorst, Corinna, Fu, Guan, Tanner, Felix C., Ruschitzka, Frank, Duru, Firat, Saguner, Ardan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8911196/
https://www.ncbi.nlm.nih.gov/pubmed/35268241
http://dx.doi.org/10.3390/jcm11051150
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author Costa, Sarah
Koch, Kristina
Gasperetti, Alessio
Akdis, Deniz
Brunckhorst, Corinna
Fu, Guan
Tanner, Felix C.
Ruschitzka, Frank
Duru, Firat
Saguner, Ardan M.
author_facet Costa, Sarah
Koch, Kristina
Gasperetti, Alessio
Akdis, Deniz
Brunckhorst, Corinna
Fu, Guan
Tanner, Felix C.
Ruschitzka, Frank
Duru, Firat
Saguner, Ardan M.
author_sort Costa, Sarah
collection PubMed
description (1) Background: Physical exercise has been suggested to promote disease progression in patients with arrhythmogenic right ventricular cardiomyopathy (ARVC). We aimed to investigate the exercise performance and ventricular function of ARVC patients during follow-up, while taking into account their adherence to exercise restriction recommendations. (2) Methods: This retrospective study included 49 patients (33 male, 67%) who had an exercise test at baseline and after 4.2 ± 1.6 years. Of the 49 ARVC patients, 27 (55%) were athletes, while 22 (45%) were non-athletes. Of the athletes, 12 (44%) continued intensive sports activity (non-adherent), while 15 (56%) stopped intensive physical activity upon recommendation (adherent). The maximum workload in Watts (W), percentage of the target workload (W%), and double product (DP) factor were measured for all patients. (3) Results: The non-adherent cohort had a significant decrease in physical performance (W at baseline vs. follow-up, p = 0.012; W% at baseline vs. follow-up, p = 0.025; DP-factor at baseline vs. follow-up, p = 0.012) over time. Left ventricular (LV) function (LV ejection fraction at baseline vs. follow-up, p = 0.082) showed a decreasing trend in the non-adherent cohort, while the performance of the adherent cohort remained at a similar level. (4) Conclusions: If intensive sports activities are not discontinued, exercise capacity and left ventricular function of athletes with ARVC deteriorates during follow-up. All patients with ARVC need to strictly adhere to the recommendation to cease intense sports activity in order to halt disease progression.
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spelling pubmed-89111962022-03-11 Changes in Exercise Capacity and Ventricular Function in Arrhythmogenic Right Ventricular Cardiomyopathy: The Impact of Sports Restriction during Follow-Up Costa, Sarah Koch, Kristina Gasperetti, Alessio Akdis, Deniz Brunckhorst, Corinna Fu, Guan Tanner, Felix C. Ruschitzka, Frank Duru, Firat Saguner, Ardan M. J Clin Med Article (1) Background: Physical exercise has been suggested to promote disease progression in patients with arrhythmogenic right ventricular cardiomyopathy (ARVC). We aimed to investigate the exercise performance and ventricular function of ARVC patients during follow-up, while taking into account their adherence to exercise restriction recommendations. (2) Methods: This retrospective study included 49 patients (33 male, 67%) who had an exercise test at baseline and after 4.2 ± 1.6 years. Of the 49 ARVC patients, 27 (55%) were athletes, while 22 (45%) were non-athletes. Of the athletes, 12 (44%) continued intensive sports activity (non-adherent), while 15 (56%) stopped intensive physical activity upon recommendation (adherent). The maximum workload in Watts (W), percentage of the target workload (W%), and double product (DP) factor were measured for all patients. (3) Results: The non-adherent cohort had a significant decrease in physical performance (W at baseline vs. follow-up, p = 0.012; W% at baseline vs. follow-up, p = 0.025; DP-factor at baseline vs. follow-up, p = 0.012) over time. Left ventricular (LV) function (LV ejection fraction at baseline vs. follow-up, p = 0.082) showed a decreasing trend in the non-adherent cohort, while the performance of the adherent cohort remained at a similar level. (4) Conclusions: If intensive sports activities are not discontinued, exercise capacity and left ventricular function of athletes with ARVC deteriorates during follow-up. All patients with ARVC need to strictly adhere to the recommendation to cease intense sports activity in order to halt disease progression. MDPI 2022-02-22 /pmc/articles/PMC8911196/ /pubmed/35268241 http://dx.doi.org/10.3390/jcm11051150 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Costa, Sarah
Koch, Kristina
Gasperetti, Alessio
Akdis, Deniz
Brunckhorst, Corinna
Fu, Guan
Tanner, Felix C.
Ruschitzka, Frank
Duru, Firat
Saguner, Ardan M.
Changes in Exercise Capacity and Ventricular Function in Arrhythmogenic Right Ventricular Cardiomyopathy: The Impact of Sports Restriction during Follow-Up
title Changes in Exercise Capacity and Ventricular Function in Arrhythmogenic Right Ventricular Cardiomyopathy: The Impact of Sports Restriction during Follow-Up
title_full Changes in Exercise Capacity and Ventricular Function in Arrhythmogenic Right Ventricular Cardiomyopathy: The Impact of Sports Restriction during Follow-Up
title_fullStr Changes in Exercise Capacity and Ventricular Function in Arrhythmogenic Right Ventricular Cardiomyopathy: The Impact of Sports Restriction during Follow-Up
title_full_unstemmed Changes in Exercise Capacity and Ventricular Function in Arrhythmogenic Right Ventricular Cardiomyopathy: The Impact of Sports Restriction during Follow-Up
title_short Changes in Exercise Capacity and Ventricular Function in Arrhythmogenic Right Ventricular Cardiomyopathy: The Impact of Sports Restriction during Follow-Up
title_sort changes in exercise capacity and ventricular function in arrhythmogenic right ventricular cardiomyopathy: the impact of sports restriction during follow-up
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8911196/
https://www.ncbi.nlm.nih.gov/pubmed/35268241
http://dx.doi.org/10.3390/jcm11051150
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