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Acute Kidney Injury Following Transcatheter Aortic Valve Implantation: Association with Contrast Media Dosage and Contrast Media Based Risk Predication Models
The effect of contrast media (CM), delivered prior to- and during transcatheter aortic valve implantation (TAVI), on kidney function, following the procedure, is debatable. Consequently, the performance of CM-based, acute kidney injury (AKI) risk prediction models is also questionable. We retrospect...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8911230/ https://www.ncbi.nlm.nih.gov/pubmed/35268271 http://dx.doi.org/10.3390/jcm11051181 |
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author | Sudarsky, Doron Drutin, Yarden Kusniec, Fabio Grosman-Rimon, Liza Lubovich, Ala Kinany, Wadia Hazanov, Evgeni Gelbstein, Michael Birati, Edo Y. Marai, Ibrahim |
author_facet | Sudarsky, Doron Drutin, Yarden Kusniec, Fabio Grosman-Rimon, Liza Lubovich, Ala Kinany, Wadia Hazanov, Evgeni Gelbstein, Michael Birati, Edo Y. Marai, Ibrahim |
author_sort | Sudarsky, Doron |
collection | PubMed |
description | The effect of contrast media (CM), delivered prior to- and during transcatheter aortic valve implantation (TAVI), on kidney function, following the procedure, is debatable. Consequently, the performance of CM-based, acute kidney injury (AKI) risk prediction models is also questionable. We retrospectively studied 210 patients that underwent TAVI. We recorded the dose of CM used prior and during TAVI, calculated the results of different AKI risk assessment models containing a CM module, and tested their association with AKI after the procedure. AKI was diagnosed in 38 patients (18.1%). The baseline estimated glomerular filtration rate (eGFR) was lower in the AKI+ group compared to AKI− group (51 ± 19.3 versus 64.5 ± 19 mL/min/1.73 mr(2), respectively). While the dose of CM delivered prior to TAVI, during TAVI or the cumulative amount of both did not differ between the groups, the results of all tested risk models were higher in AKI+ patients. However, by multivariable analysis, only eGFR had a consistent independent association with AKI. We suggest that the dose of CM delivered prior or during TAVI is not associated with AKI and that the predictive power of CM based AKI risk models is, in all probability, limited to eGFR alone. |
format | Online Article Text |
id | pubmed-8911230 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-89112302022-03-11 Acute Kidney Injury Following Transcatheter Aortic Valve Implantation: Association with Contrast Media Dosage and Contrast Media Based Risk Predication Models Sudarsky, Doron Drutin, Yarden Kusniec, Fabio Grosman-Rimon, Liza Lubovich, Ala Kinany, Wadia Hazanov, Evgeni Gelbstein, Michael Birati, Edo Y. Marai, Ibrahim J Clin Med Article The effect of contrast media (CM), delivered prior to- and during transcatheter aortic valve implantation (TAVI), on kidney function, following the procedure, is debatable. Consequently, the performance of CM-based, acute kidney injury (AKI) risk prediction models is also questionable. We retrospectively studied 210 patients that underwent TAVI. We recorded the dose of CM used prior and during TAVI, calculated the results of different AKI risk assessment models containing a CM module, and tested their association with AKI after the procedure. AKI was diagnosed in 38 patients (18.1%). The baseline estimated glomerular filtration rate (eGFR) was lower in the AKI+ group compared to AKI− group (51 ± 19.3 versus 64.5 ± 19 mL/min/1.73 mr(2), respectively). While the dose of CM delivered prior to TAVI, during TAVI or the cumulative amount of both did not differ between the groups, the results of all tested risk models were higher in AKI+ patients. However, by multivariable analysis, only eGFR had a consistent independent association with AKI. We suggest that the dose of CM delivered prior or during TAVI is not associated with AKI and that the predictive power of CM based AKI risk models is, in all probability, limited to eGFR alone. MDPI 2022-02-23 /pmc/articles/PMC8911230/ /pubmed/35268271 http://dx.doi.org/10.3390/jcm11051181 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Sudarsky, Doron Drutin, Yarden Kusniec, Fabio Grosman-Rimon, Liza Lubovich, Ala Kinany, Wadia Hazanov, Evgeni Gelbstein, Michael Birati, Edo Y. Marai, Ibrahim Acute Kidney Injury Following Transcatheter Aortic Valve Implantation: Association with Contrast Media Dosage and Contrast Media Based Risk Predication Models |
title | Acute Kidney Injury Following Transcatheter Aortic Valve Implantation: Association with Contrast Media Dosage and Contrast Media Based Risk Predication Models |
title_full | Acute Kidney Injury Following Transcatheter Aortic Valve Implantation: Association with Contrast Media Dosage and Contrast Media Based Risk Predication Models |
title_fullStr | Acute Kidney Injury Following Transcatheter Aortic Valve Implantation: Association with Contrast Media Dosage and Contrast Media Based Risk Predication Models |
title_full_unstemmed | Acute Kidney Injury Following Transcatheter Aortic Valve Implantation: Association with Contrast Media Dosage and Contrast Media Based Risk Predication Models |
title_short | Acute Kidney Injury Following Transcatheter Aortic Valve Implantation: Association with Contrast Media Dosage and Contrast Media Based Risk Predication Models |
title_sort | acute kidney injury following transcatheter aortic valve implantation: association with contrast media dosage and contrast media based risk predication models |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8911230/ https://www.ncbi.nlm.nih.gov/pubmed/35268271 http://dx.doi.org/10.3390/jcm11051181 |
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