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Morphological and Functional Changes of Meibomian Glands in Pediatric and Adult Patients with Allergic Conjunctivitis

Allergic conjunctivitis (AC) is one of the most common ocular disorders in clinical practice and is associated with meibomian gland dysfunction. This study aimed to explore the morphological and functional changes of meibomian glands (MGs) in pediatric and adult patients with AC and to analyze their...

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Autores principales: Wu, Yuqing, Jiang, Hao, Zhou, Xujiao, Zhai, Zimeng, Yang, Pei, Zhou, Shuyun, Gu, Hao, Xu, Jianjiang, Hong, Jiaxu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8911235/
https://www.ncbi.nlm.nih.gov/pubmed/35268518
http://dx.doi.org/10.3390/jcm11051427
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author Wu, Yuqing
Jiang, Hao
Zhou, Xujiao
Zhai, Zimeng
Yang, Pei
Zhou, Shuyun
Gu, Hao
Xu, Jianjiang
Hong, Jiaxu
author_facet Wu, Yuqing
Jiang, Hao
Zhou, Xujiao
Zhai, Zimeng
Yang, Pei
Zhou, Shuyun
Gu, Hao
Xu, Jianjiang
Hong, Jiaxu
author_sort Wu, Yuqing
collection PubMed
description Allergic conjunctivitis (AC) is one of the most common ocular disorders in clinical practice and is associated with meibomian gland dysfunction. This study aimed to explore the morphological and functional changes of meibomian glands (MGs) in pediatric and adult patients with AC and to analyze their potential predictors. In our prospective, observational cohort study, a total of 59 patients with AC were enrolled, with 30 patients aged ≤16 years in the pediatric group and 29 patients in the adult group. All patients underwent examinations at baseline and last visit when the complete resolution of conjunctival papillae was identified. An automatic MG analyzer was used to measure the morphological and functional parameters of MGs, including their area ratio (GA), tortuosity index (TI), and signal index (SI). Two groups were comparable at baseline in terms of characteristics and MG parameters (p > 0.05). The morphological (length, square, and GA) and functional MG parameters (SI) of AC patients significantly improved in the pediatric group after treatment (all p < 0.05), but not in the adult group. The change in the GA correlated with age, sex, GA, TI, and SI at baseline (all p < 0.05). Age (p = 0.001) and GA (p < 0.001) at baseline were predictors of an improvement in the GA of MGs. The findings showed that the structure and function of MGs in pediatric patients with AC seem to improve after the conjunctival papillae disappear, but not in adult patients.
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spelling pubmed-89112352022-03-11 Morphological and Functional Changes of Meibomian Glands in Pediatric and Adult Patients with Allergic Conjunctivitis Wu, Yuqing Jiang, Hao Zhou, Xujiao Zhai, Zimeng Yang, Pei Zhou, Shuyun Gu, Hao Xu, Jianjiang Hong, Jiaxu J Clin Med Article Allergic conjunctivitis (AC) is one of the most common ocular disorders in clinical practice and is associated with meibomian gland dysfunction. This study aimed to explore the morphological and functional changes of meibomian glands (MGs) in pediatric and adult patients with AC and to analyze their potential predictors. In our prospective, observational cohort study, a total of 59 patients with AC were enrolled, with 30 patients aged ≤16 years in the pediatric group and 29 patients in the adult group. All patients underwent examinations at baseline and last visit when the complete resolution of conjunctival papillae was identified. An automatic MG analyzer was used to measure the morphological and functional parameters of MGs, including their area ratio (GA), tortuosity index (TI), and signal index (SI). Two groups were comparable at baseline in terms of characteristics and MG parameters (p > 0.05). The morphological (length, square, and GA) and functional MG parameters (SI) of AC patients significantly improved in the pediatric group after treatment (all p < 0.05), but not in the adult group. The change in the GA correlated with age, sex, GA, TI, and SI at baseline (all p < 0.05). Age (p = 0.001) and GA (p < 0.001) at baseline were predictors of an improvement in the GA of MGs. The findings showed that the structure and function of MGs in pediatric patients with AC seem to improve after the conjunctival papillae disappear, but not in adult patients. MDPI 2022-03-04 /pmc/articles/PMC8911235/ /pubmed/35268518 http://dx.doi.org/10.3390/jcm11051427 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wu, Yuqing
Jiang, Hao
Zhou, Xujiao
Zhai, Zimeng
Yang, Pei
Zhou, Shuyun
Gu, Hao
Xu, Jianjiang
Hong, Jiaxu
Morphological and Functional Changes of Meibomian Glands in Pediatric and Adult Patients with Allergic Conjunctivitis
title Morphological and Functional Changes of Meibomian Glands in Pediatric and Adult Patients with Allergic Conjunctivitis
title_full Morphological and Functional Changes of Meibomian Glands in Pediatric and Adult Patients with Allergic Conjunctivitis
title_fullStr Morphological and Functional Changes of Meibomian Glands in Pediatric and Adult Patients with Allergic Conjunctivitis
title_full_unstemmed Morphological and Functional Changes of Meibomian Glands in Pediatric and Adult Patients with Allergic Conjunctivitis
title_short Morphological and Functional Changes of Meibomian Glands in Pediatric and Adult Patients with Allergic Conjunctivitis
title_sort morphological and functional changes of meibomian glands in pediatric and adult patients with allergic conjunctivitis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8911235/
https://www.ncbi.nlm.nih.gov/pubmed/35268518
http://dx.doi.org/10.3390/jcm11051427
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