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The Role of Extracellular Matrix Proteins in Breast Cancer

The extracellular matrix is a structure composed of many molecules, including fibrillar (types I, II, III, V, XI, XXIV, XXVII) and non-fibrillar collagens (mainly basement membrane collagens: types IV, VIII, X), non-collagenous glycoproteins (elastin, laminin, fibronectin, thrombospondin, tenascin,...

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Autores principales: Lepucki, Arkadiusz, Orlińska, Kinga, Mielczarek-Palacz, Aleksandra, Kabut, Jacek, Olczyk, Pawel, Komosińska-Vassev, Katarzyna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8911242/
https://www.ncbi.nlm.nih.gov/pubmed/35268340
http://dx.doi.org/10.3390/jcm11051250
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author Lepucki, Arkadiusz
Orlińska, Kinga
Mielczarek-Palacz, Aleksandra
Kabut, Jacek
Olczyk, Pawel
Komosińska-Vassev, Katarzyna
author_facet Lepucki, Arkadiusz
Orlińska, Kinga
Mielczarek-Palacz, Aleksandra
Kabut, Jacek
Olczyk, Pawel
Komosińska-Vassev, Katarzyna
author_sort Lepucki, Arkadiusz
collection PubMed
description The extracellular matrix is a structure composed of many molecules, including fibrillar (types I, II, III, V, XI, XXIV, XXVII) and non-fibrillar collagens (mainly basement membrane collagens: types IV, VIII, X), non-collagenous glycoproteins (elastin, laminin, fibronectin, thrombospondin, tenascin, osteopontin, osteonectin, entactin, periostin) embedded in a gel of negatively charged water-retaining glycosaminoglycans (GAGs) such as non-sulfated hyaluronic acid (HA) and sulfated GAGs which are linked to a core protein to form proteoglycans (PGs). This highly dynamic molecular network provides critical biochemical and biomechanical cues that mediate the cell–cell and cell–matrix interactions, influence cell growth, migration and differentiation and serve as a reservoir of cytokines and growth factors’ action. The breakdown of normal ECM and its replacement with tumor ECM modulate the tumor microenvironment (TME) composition and is an essential part of tumorigenesis and metastasis, acting as key driver for malignant progression. Abnormal ECM also deregulate behavior of stromal cells as well as facilitating tumor-associated angiogenesis and inflammation. Thus, the tumor matrix modulates each of the classically defined hallmarks of cancer promoting the growth, survival and invasion of the cancer. Moreover, various ECM-derived components modulate the immune response affecting T cells, tumor-associated macrophages (TAM), dendritic cells and cancer-associated fibroblasts (CAF). This review article considers the role that extracellular matrix play in breast cancer. Determining the detailed connections between the ECM and cellular processes has helped to identify novel disease markers and therapeutic targets.
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spelling pubmed-89112422022-03-11 The Role of Extracellular Matrix Proteins in Breast Cancer Lepucki, Arkadiusz Orlińska, Kinga Mielczarek-Palacz, Aleksandra Kabut, Jacek Olczyk, Pawel Komosińska-Vassev, Katarzyna J Clin Med Review The extracellular matrix is a structure composed of many molecules, including fibrillar (types I, II, III, V, XI, XXIV, XXVII) and non-fibrillar collagens (mainly basement membrane collagens: types IV, VIII, X), non-collagenous glycoproteins (elastin, laminin, fibronectin, thrombospondin, tenascin, osteopontin, osteonectin, entactin, periostin) embedded in a gel of negatively charged water-retaining glycosaminoglycans (GAGs) such as non-sulfated hyaluronic acid (HA) and sulfated GAGs which are linked to a core protein to form proteoglycans (PGs). This highly dynamic molecular network provides critical biochemical and biomechanical cues that mediate the cell–cell and cell–matrix interactions, influence cell growth, migration and differentiation and serve as a reservoir of cytokines and growth factors’ action. The breakdown of normal ECM and its replacement with tumor ECM modulate the tumor microenvironment (TME) composition and is an essential part of tumorigenesis and metastasis, acting as key driver for malignant progression. Abnormal ECM also deregulate behavior of stromal cells as well as facilitating tumor-associated angiogenesis and inflammation. Thus, the tumor matrix modulates each of the classically defined hallmarks of cancer promoting the growth, survival and invasion of the cancer. Moreover, various ECM-derived components modulate the immune response affecting T cells, tumor-associated macrophages (TAM), dendritic cells and cancer-associated fibroblasts (CAF). This review article considers the role that extracellular matrix play in breast cancer. Determining the detailed connections between the ECM and cellular processes has helped to identify novel disease markers and therapeutic targets. MDPI 2022-02-25 /pmc/articles/PMC8911242/ /pubmed/35268340 http://dx.doi.org/10.3390/jcm11051250 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lepucki, Arkadiusz
Orlińska, Kinga
Mielczarek-Palacz, Aleksandra
Kabut, Jacek
Olczyk, Pawel
Komosińska-Vassev, Katarzyna
The Role of Extracellular Matrix Proteins in Breast Cancer
title The Role of Extracellular Matrix Proteins in Breast Cancer
title_full The Role of Extracellular Matrix Proteins in Breast Cancer
title_fullStr The Role of Extracellular Matrix Proteins in Breast Cancer
title_full_unstemmed The Role of Extracellular Matrix Proteins in Breast Cancer
title_short The Role of Extracellular Matrix Proteins in Breast Cancer
title_sort role of extracellular matrix proteins in breast cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8911242/
https://www.ncbi.nlm.nih.gov/pubmed/35268340
http://dx.doi.org/10.3390/jcm11051250
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