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Clinical Outcomes in Patients Aged 80 Years or Older Receiving Non-Invasive Respiratory Support for Hypoxemic Acute Respiratory Failure Consequent to COVID-19
As the clinical outcome of octogenarian patients hospitalised for COVID-19 is very poor, here we assessed the clinical characteristics and outcomes of patients aged 80 year or older hospitalised for COVID-19 receiving non-invasive respiratory support (NIRS). A multicentre, retrospective, observation...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8911338/ https://www.ncbi.nlm.nih.gov/pubmed/35268463 http://dx.doi.org/10.3390/jcm11051372 |
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author | Vianello, Andrea De Vita, Nello Scotti, Lorenza Guarnieri, Gabriella Confalonieri, Marco Bonato, Valeria Molena, Beatrice Maestrone, Carlo Airoldi, Gianluca Olivieri, Carlo Sainaghi, Pier Paolo Lionello, Federico Arcaro, Giovanna Della Corte, Francesco Navalesi, Paolo Vaschetto, Rosanna |
author_facet | Vianello, Andrea De Vita, Nello Scotti, Lorenza Guarnieri, Gabriella Confalonieri, Marco Bonato, Valeria Molena, Beatrice Maestrone, Carlo Airoldi, Gianluca Olivieri, Carlo Sainaghi, Pier Paolo Lionello, Federico Arcaro, Giovanna Della Corte, Francesco Navalesi, Paolo Vaschetto, Rosanna |
author_sort | Vianello, Andrea |
collection | PubMed |
description | As the clinical outcome of octogenarian patients hospitalised for COVID-19 is very poor, here we assessed the clinical characteristics and outcomes of patients aged 80 year or older hospitalised for COVID-19 receiving non-invasive respiratory support (NIRS). A multicentre, retrospective, observational study was conducted in seven hospitals in Northern Italy. All patients aged ≥80 years with COVID-19 associated hypoxemic acute respiratory failure (hARF) undergoing NIRS between 24 February 2020, and 31 March 2021, were included. Out of 252 study participants, 156 (61.9%) and 163 (64.6%) died during hospital stay and within 90 days from hospital admission, respectively. In this case, 228 (90.5%) patients only received NIRS (NIRS group), while 24 (9.5%) were treated with invasive mechanical ventilation (IMV) after NIRS failure (NIRS+IMV group). In-hospital mortality did not significantly differ between NIRS and NIRS+IMV group (61.0% vs. 70.8%, respectively; p = 0.507), while survival probability at 90 days was significantly higher for NIRS compared to NIRS+IMV patients (0.379 vs. 0.147; p = 0.0025). The outcome of octogenarian patients with COVID-19 receiving NIRS is quite poor. Caution should be used when considering transition from NIRS to IMV after NIRS failure. |
format | Online Article Text |
id | pubmed-8911338 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-89113382022-03-11 Clinical Outcomes in Patients Aged 80 Years or Older Receiving Non-Invasive Respiratory Support for Hypoxemic Acute Respiratory Failure Consequent to COVID-19 Vianello, Andrea De Vita, Nello Scotti, Lorenza Guarnieri, Gabriella Confalonieri, Marco Bonato, Valeria Molena, Beatrice Maestrone, Carlo Airoldi, Gianluca Olivieri, Carlo Sainaghi, Pier Paolo Lionello, Federico Arcaro, Giovanna Della Corte, Francesco Navalesi, Paolo Vaschetto, Rosanna J Clin Med Article As the clinical outcome of octogenarian patients hospitalised for COVID-19 is very poor, here we assessed the clinical characteristics and outcomes of patients aged 80 year or older hospitalised for COVID-19 receiving non-invasive respiratory support (NIRS). A multicentre, retrospective, observational study was conducted in seven hospitals in Northern Italy. All patients aged ≥80 years with COVID-19 associated hypoxemic acute respiratory failure (hARF) undergoing NIRS between 24 February 2020, and 31 March 2021, were included. Out of 252 study participants, 156 (61.9%) and 163 (64.6%) died during hospital stay and within 90 days from hospital admission, respectively. In this case, 228 (90.5%) patients only received NIRS (NIRS group), while 24 (9.5%) were treated with invasive mechanical ventilation (IMV) after NIRS failure (NIRS+IMV group). In-hospital mortality did not significantly differ between NIRS and NIRS+IMV group (61.0% vs. 70.8%, respectively; p = 0.507), while survival probability at 90 days was significantly higher for NIRS compared to NIRS+IMV patients (0.379 vs. 0.147; p = 0.0025). The outcome of octogenarian patients with COVID-19 receiving NIRS is quite poor. Caution should be used when considering transition from NIRS to IMV after NIRS failure. MDPI 2022-03-02 /pmc/articles/PMC8911338/ /pubmed/35268463 http://dx.doi.org/10.3390/jcm11051372 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Vianello, Andrea De Vita, Nello Scotti, Lorenza Guarnieri, Gabriella Confalonieri, Marco Bonato, Valeria Molena, Beatrice Maestrone, Carlo Airoldi, Gianluca Olivieri, Carlo Sainaghi, Pier Paolo Lionello, Federico Arcaro, Giovanna Della Corte, Francesco Navalesi, Paolo Vaschetto, Rosanna Clinical Outcomes in Patients Aged 80 Years or Older Receiving Non-Invasive Respiratory Support for Hypoxemic Acute Respiratory Failure Consequent to COVID-19 |
title | Clinical Outcomes in Patients Aged 80 Years or Older Receiving Non-Invasive Respiratory Support for Hypoxemic Acute Respiratory Failure Consequent to COVID-19 |
title_full | Clinical Outcomes in Patients Aged 80 Years or Older Receiving Non-Invasive Respiratory Support for Hypoxemic Acute Respiratory Failure Consequent to COVID-19 |
title_fullStr | Clinical Outcomes in Patients Aged 80 Years or Older Receiving Non-Invasive Respiratory Support for Hypoxemic Acute Respiratory Failure Consequent to COVID-19 |
title_full_unstemmed | Clinical Outcomes in Patients Aged 80 Years or Older Receiving Non-Invasive Respiratory Support for Hypoxemic Acute Respiratory Failure Consequent to COVID-19 |
title_short | Clinical Outcomes in Patients Aged 80 Years or Older Receiving Non-Invasive Respiratory Support for Hypoxemic Acute Respiratory Failure Consequent to COVID-19 |
title_sort | clinical outcomes in patients aged 80 years or older receiving non-invasive respiratory support for hypoxemic acute respiratory failure consequent to covid-19 |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8911338/ https://www.ncbi.nlm.nih.gov/pubmed/35268463 http://dx.doi.org/10.3390/jcm11051372 |
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