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Clinical Outcomes in Patients Aged 80 Years or Older Receiving Non-Invasive Respiratory Support for Hypoxemic Acute Respiratory Failure Consequent to COVID-19

As the clinical outcome of octogenarian patients hospitalised for COVID-19 is very poor, here we assessed the clinical characteristics and outcomes of patients aged 80 year or older hospitalised for COVID-19 receiving non-invasive respiratory support (NIRS). A multicentre, retrospective, observation...

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Autores principales: Vianello, Andrea, De Vita, Nello, Scotti, Lorenza, Guarnieri, Gabriella, Confalonieri, Marco, Bonato, Valeria, Molena, Beatrice, Maestrone, Carlo, Airoldi, Gianluca, Olivieri, Carlo, Sainaghi, Pier Paolo, Lionello, Federico, Arcaro, Giovanna, Della Corte, Francesco, Navalesi, Paolo, Vaschetto, Rosanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8911338/
https://www.ncbi.nlm.nih.gov/pubmed/35268463
http://dx.doi.org/10.3390/jcm11051372
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author Vianello, Andrea
De Vita, Nello
Scotti, Lorenza
Guarnieri, Gabriella
Confalonieri, Marco
Bonato, Valeria
Molena, Beatrice
Maestrone, Carlo
Airoldi, Gianluca
Olivieri, Carlo
Sainaghi, Pier Paolo
Lionello, Federico
Arcaro, Giovanna
Della Corte, Francesco
Navalesi, Paolo
Vaschetto, Rosanna
author_facet Vianello, Andrea
De Vita, Nello
Scotti, Lorenza
Guarnieri, Gabriella
Confalonieri, Marco
Bonato, Valeria
Molena, Beatrice
Maestrone, Carlo
Airoldi, Gianluca
Olivieri, Carlo
Sainaghi, Pier Paolo
Lionello, Federico
Arcaro, Giovanna
Della Corte, Francesco
Navalesi, Paolo
Vaschetto, Rosanna
author_sort Vianello, Andrea
collection PubMed
description As the clinical outcome of octogenarian patients hospitalised for COVID-19 is very poor, here we assessed the clinical characteristics and outcomes of patients aged 80 year or older hospitalised for COVID-19 receiving non-invasive respiratory support (NIRS). A multicentre, retrospective, observational study was conducted in seven hospitals in Northern Italy. All patients aged ≥80 years with COVID-19 associated hypoxemic acute respiratory failure (hARF) undergoing NIRS between 24 February 2020, and 31 March 2021, were included. Out of 252 study participants, 156 (61.9%) and 163 (64.6%) died during hospital stay and within 90 days from hospital admission, respectively. In this case, 228 (90.5%) patients only received NIRS (NIRS group), while 24 (9.5%) were treated with invasive mechanical ventilation (IMV) after NIRS failure (NIRS+IMV group). In-hospital mortality did not significantly differ between NIRS and NIRS+IMV group (61.0% vs. 70.8%, respectively; p = 0.507), while survival probability at 90 days was significantly higher for NIRS compared to NIRS+IMV patients (0.379 vs. 0.147; p = 0.0025). The outcome of octogenarian patients with COVID-19 receiving NIRS is quite poor. Caution should be used when considering transition from NIRS to IMV after NIRS failure.
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spelling pubmed-89113382022-03-11 Clinical Outcomes in Patients Aged 80 Years or Older Receiving Non-Invasive Respiratory Support for Hypoxemic Acute Respiratory Failure Consequent to COVID-19 Vianello, Andrea De Vita, Nello Scotti, Lorenza Guarnieri, Gabriella Confalonieri, Marco Bonato, Valeria Molena, Beatrice Maestrone, Carlo Airoldi, Gianluca Olivieri, Carlo Sainaghi, Pier Paolo Lionello, Federico Arcaro, Giovanna Della Corte, Francesco Navalesi, Paolo Vaschetto, Rosanna J Clin Med Article As the clinical outcome of octogenarian patients hospitalised for COVID-19 is very poor, here we assessed the clinical characteristics and outcomes of patients aged 80 year or older hospitalised for COVID-19 receiving non-invasive respiratory support (NIRS). A multicentre, retrospective, observational study was conducted in seven hospitals in Northern Italy. All patients aged ≥80 years with COVID-19 associated hypoxemic acute respiratory failure (hARF) undergoing NIRS between 24 February 2020, and 31 March 2021, were included. Out of 252 study participants, 156 (61.9%) and 163 (64.6%) died during hospital stay and within 90 days from hospital admission, respectively. In this case, 228 (90.5%) patients only received NIRS (NIRS group), while 24 (9.5%) were treated with invasive mechanical ventilation (IMV) after NIRS failure (NIRS+IMV group). In-hospital mortality did not significantly differ between NIRS and NIRS+IMV group (61.0% vs. 70.8%, respectively; p = 0.507), while survival probability at 90 days was significantly higher for NIRS compared to NIRS+IMV patients (0.379 vs. 0.147; p = 0.0025). The outcome of octogenarian patients with COVID-19 receiving NIRS is quite poor. Caution should be used when considering transition from NIRS to IMV after NIRS failure. MDPI 2022-03-02 /pmc/articles/PMC8911338/ /pubmed/35268463 http://dx.doi.org/10.3390/jcm11051372 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Vianello, Andrea
De Vita, Nello
Scotti, Lorenza
Guarnieri, Gabriella
Confalonieri, Marco
Bonato, Valeria
Molena, Beatrice
Maestrone, Carlo
Airoldi, Gianluca
Olivieri, Carlo
Sainaghi, Pier Paolo
Lionello, Federico
Arcaro, Giovanna
Della Corte, Francesco
Navalesi, Paolo
Vaschetto, Rosanna
Clinical Outcomes in Patients Aged 80 Years or Older Receiving Non-Invasive Respiratory Support for Hypoxemic Acute Respiratory Failure Consequent to COVID-19
title Clinical Outcomes in Patients Aged 80 Years or Older Receiving Non-Invasive Respiratory Support for Hypoxemic Acute Respiratory Failure Consequent to COVID-19
title_full Clinical Outcomes in Patients Aged 80 Years or Older Receiving Non-Invasive Respiratory Support for Hypoxemic Acute Respiratory Failure Consequent to COVID-19
title_fullStr Clinical Outcomes in Patients Aged 80 Years or Older Receiving Non-Invasive Respiratory Support for Hypoxemic Acute Respiratory Failure Consequent to COVID-19
title_full_unstemmed Clinical Outcomes in Patients Aged 80 Years or Older Receiving Non-Invasive Respiratory Support for Hypoxemic Acute Respiratory Failure Consequent to COVID-19
title_short Clinical Outcomes in Patients Aged 80 Years or Older Receiving Non-Invasive Respiratory Support for Hypoxemic Acute Respiratory Failure Consequent to COVID-19
title_sort clinical outcomes in patients aged 80 years or older receiving non-invasive respiratory support for hypoxemic acute respiratory failure consequent to covid-19
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8911338/
https://www.ncbi.nlm.nih.gov/pubmed/35268463
http://dx.doi.org/10.3390/jcm11051372
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