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KD Diagnosis Does Not Increase Cardiovascular Risk in Children According to Dynamic Intima–Media Roughness Measurements

Background: Kawasaki Disease (KD) is a generalized vasculitis in childhood with possible long-term impact on cardiovascular health besides the presence of coronary artery lesions. Standard vascular parameters such as carotid intima–media thickness (cIMT) have not been established as reliable markers...

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Autores principales: König, Miriam, Ullmann, Theresa, Pastor-Villaescusa, Belén, Dalla-Pozza, Robert, Bohlig, Sarah, Schmidt-Trucksäss, Arno, Pattathu, Joseph, Haas, Nikolaus A., Jakob, André
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8911373/
https://www.ncbi.nlm.nih.gov/pubmed/35268268
http://dx.doi.org/10.3390/jcm11051177
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author König, Miriam
Ullmann, Theresa
Pastor-Villaescusa, Belén
Dalla-Pozza, Robert
Bohlig, Sarah
Schmidt-Trucksäss, Arno
Pattathu, Joseph
Haas, Nikolaus A.
Jakob, André
author_facet König, Miriam
Ullmann, Theresa
Pastor-Villaescusa, Belén
Dalla-Pozza, Robert
Bohlig, Sarah
Schmidt-Trucksäss, Arno
Pattathu, Joseph
Haas, Nikolaus A.
Jakob, André
author_sort König, Miriam
collection PubMed
description Background: Kawasaki Disease (KD) is a generalized vasculitis in childhood with possible long-term impact on cardiovascular health besides the presence of coronary artery lesions. Standard vascular parameters such as carotid intima–media thickness (cIMT) have not been established as reliable markers of vascular anomalies after KD. The carotid intima–media roughness (cIMR) representing carotid intimal surface structure is considered a promising surrogate marker for predicting cardiovascular risk even beyond cIMT. We therefore measured cIMR in patients with a history of KD in comparison to healthy controls to investigate whether KD itself and/or KD key clinical aspects are associated with cIMR alterations in the long-term. Methods: We assessed cIMR in this case-control study (44 KD, mean age in years (SD); 13.4 (7.5); 36 controls, mean age 12.1 (5.3)) approximately matched by sex and age. Different clinical outcomes such as the coronary artery status and acute phase inflammation data were analyzed in association with cIMR values. Results: When comparing all patients with KD to healthy controls, we detected no significant difference in cIMR. None of the clinical parameters indicating the disease severity, such as the persistence of coronary artery aneurysm, were significantly associated with our cIMR values. However, according to our marginally significant findings (p = 0.044), we postulate that the end-diastolic cIMR may be rougher than the end-systolic values in KD patients. Conclusions: We detected no significant differences in cIMR between KD patients and controls that could confirm any evidence that KD predisposes patients to a subsequent general arteriopathy. Our results, however, need to be interpreted in the light of the low number of study participants.
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spelling pubmed-89113732022-03-11 KD Diagnosis Does Not Increase Cardiovascular Risk in Children According to Dynamic Intima–Media Roughness Measurements König, Miriam Ullmann, Theresa Pastor-Villaescusa, Belén Dalla-Pozza, Robert Bohlig, Sarah Schmidt-Trucksäss, Arno Pattathu, Joseph Haas, Nikolaus A. Jakob, André J Clin Med Article Background: Kawasaki Disease (KD) is a generalized vasculitis in childhood with possible long-term impact on cardiovascular health besides the presence of coronary artery lesions. Standard vascular parameters such as carotid intima–media thickness (cIMT) have not been established as reliable markers of vascular anomalies after KD. The carotid intima–media roughness (cIMR) representing carotid intimal surface structure is considered a promising surrogate marker for predicting cardiovascular risk even beyond cIMT. We therefore measured cIMR in patients with a history of KD in comparison to healthy controls to investigate whether KD itself and/or KD key clinical aspects are associated with cIMR alterations in the long-term. Methods: We assessed cIMR in this case-control study (44 KD, mean age in years (SD); 13.4 (7.5); 36 controls, mean age 12.1 (5.3)) approximately matched by sex and age. Different clinical outcomes such as the coronary artery status and acute phase inflammation data were analyzed in association with cIMR values. Results: When comparing all patients with KD to healthy controls, we detected no significant difference in cIMR. None of the clinical parameters indicating the disease severity, such as the persistence of coronary artery aneurysm, were significantly associated with our cIMR values. However, according to our marginally significant findings (p = 0.044), we postulate that the end-diastolic cIMR may be rougher than the end-systolic values in KD patients. Conclusions: We detected no significant differences in cIMR between KD patients and controls that could confirm any evidence that KD predisposes patients to a subsequent general arteriopathy. Our results, however, need to be interpreted in the light of the low number of study participants. MDPI 2022-02-22 /pmc/articles/PMC8911373/ /pubmed/35268268 http://dx.doi.org/10.3390/jcm11051177 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
König, Miriam
Ullmann, Theresa
Pastor-Villaescusa, Belén
Dalla-Pozza, Robert
Bohlig, Sarah
Schmidt-Trucksäss, Arno
Pattathu, Joseph
Haas, Nikolaus A.
Jakob, André
KD Diagnosis Does Not Increase Cardiovascular Risk in Children According to Dynamic Intima–Media Roughness Measurements
title KD Diagnosis Does Not Increase Cardiovascular Risk in Children According to Dynamic Intima–Media Roughness Measurements
title_full KD Diagnosis Does Not Increase Cardiovascular Risk in Children According to Dynamic Intima–Media Roughness Measurements
title_fullStr KD Diagnosis Does Not Increase Cardiovascular Risk in Children According to Dynamic Intima–Media Roughness Measurements
title_full_unstemmed KD Diagnosis Does Not Increase Cardiovascular Risk in Children According to Dynamic Intima–Media Roughness Measurements
title_short KD Diagnosis Does Not Increase Cardiovascular Risk in Children According to Dynamic Intima–Media Roughness Measurements
title_sort kd diagnosis does not increase cardiovascular risk in children according to dynamic intima–media roughness measurements
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8911373/
https://www.ncbi.nlm.nih.gov/pubmed/35268268
http://dx.doi.org/10.3390/jcm11051177
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