Generation of a Dystrophin Mutant in Dog by Nuclear Transfer Using CRISPR/Cas9-Mediated Somatic Cells: A Preliminary Study

Dystrophinopathy is caused by mutations in the dystrophin gene, which lead to progressive muscle degeneration, necrosis, and finally, death. Recently, golden retrievers have been suggested as a useful animal model for studying human dystrophinopathy, but the model has limitations due to difficulty i...

Descripción completa

Detalles Bibliográficos
Autores principales: Oh, Hyun Ju, Chung, Eugene, Kim, Jaehwan, Kim, Min Jung, Kim, Geon A., Lee, Seok Hee, Ra, Kihae, Eom, Kidong, Park, Soojin, Chae, Jong-Hee, Kim, Jin-Soo, Lee, Byeong Chun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8911381/
https://www.ncbi.nlm.nih.gov/pubmed/35270040
http://dx.doi.org/10.3390/ijms23052898

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8911381/
https://www.ncbi.nlm.nih.gov/pubmed/35270040
http://dx.doi.org/10.3390/ijms23052898

Ejemplares similares