Cargando…

Synthesis, Biological Activity and Molecular Docking Studies of Novel Nicotinic Acid Derivatives

In our research, we used nicotinic acid as a starting compound, which was subjected to a series of condensation reactions with appropriate aldehydes. As a result of these reactions, we were able to obtain a series of twelve acylhydrazones, two of which showed promising activity against Gram-positive...

Descripción completa

Detalles Bibliográficos
Autores principales:	Paruch, Kinga, Biernasiuk, Anna, Khylyuk, Dmytro, Paduch, Roman, Wujec, Monika, Popiołek, Łukasz
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8911400/ https://www.ncbi.nlm.nih.gov/pubmed/35269966 http://dx.doi.org/10.3390/ijms23052823

Ejemplares similares

Synthesis and in vitro antimicrobial activity screening of new pipemidic acid derivatives
por: Popiołek, Łukasz, et al.
Publicado: (2018)

Novel 3-Acetyl-2,5-disubstituted-1,3,4-oxadiazolines: Synthesis and Biological Activity
por: Paruch, Kinga, et al.
Publicado: (2020)

Novel 2,4,6-Trimethylbenzenesulfonyl Hydrazones with Antibacterial Activity: Synthesis and In Vitro Study
por: Popiołek, Łukasz, et al.
Publicado: (2021)

Biological Activity, Lipophilicity and Cytotoxicity of Novel 3-Acetyl-2,5-disubstituted-1,3,4-oxadiazolines
por: Paruch, Kinga, et al.
Publicado: (2021)

Design, Synthesis, Antibacterial Evaluations and In Silico Studies of Novel Thiosemicarbazides and 1,3,4-Thiadiazoles
por: Janowska, Sara, et al.
Publicado: (2022)

Synthesis and Biological Evaluation of New Schiff Bases Derived from 4-Amino-5-(3-fluorophenyl)-1,2,4-triazole-3-thione
por: Janowska, Sara, et al.
Publicado: (2023)

Synthesis and investigation of antimicrobial activities of nitrofurazone analogues containing hydrazide-hydrazone moiety
por: Popiołek, Łukasz, et al.
Publicado: (2017)

Synthesis and Anticancer Activity of 1,3,4-Thiadiazoles with 3-Methoxyphenyl Substituent
por: Janowska, Sara, et al.
Publicado: (2022)

New 1,3,4-Thiadiazole Derivatives with Anticancer Activity
por: Janowska, Sara, et al.
Publicado: (2022)

Synthesis, Biological Activity, ADME and Molecular Docking Studies of Novel Ursolic Acid Derivatives as Potent Anticancer Agents
por: Michalak, Olga, et al.
Publicado: (2023)

Thiazoles with cyclopropyl fragment as antifungal, anticonvulsant, and anti-Toxoplasma gondii agents: synthesis, toxicity evaluation, and molecular docking study
por: Łączkowski, Krzysztof Z., et al.
Publicado: (2018)

Synthesis, Characterization, and Biological Evaluation of Meldrum’s Acid Derivatives: Dual Activity and Molecular Docking Study
por: Bukhari, Syed Nasir Abbas, et al.
Publicado: (2023)

Synthesis, crystallographic characterization, molecular docking and biological activity of isoquinoline derivatives
por: Abuelizz, Hatem A., et al.
Publicado: (2017)

Germacrone derivatives: synthesis, biological activity, molecular docking studies and molecular dynamics simulations
por: Wu, Jie, et al.
Publicado: (2017)

Cinnamide Derivatives as Mammalian Arginase Inhibitors: Synthesis, Biological Evaluation and Molecular Docking
por: Pham, Thanh-Nhat, et al.
Publicado: (2016)

Synthesis, molecular docking and biological evaluation of bis-pyrimidine Schiff base derivatives
por: Kumar, Sanjiv, et al.
Publicado: (2017)

Triazolo Based-Thiadiazole Derivatives. Synthesis, Biological Evaluation and Molecular Docking Studies
por: Kamoutsis, Charalampos, et al.
Publicado: (2021)

Synthesis, characterization, molecular docking and biological evaluation of Schiff Base derivatives of cefpodoxime
por: Mahmood, Waqas, et al.
Publicado: (2022)

Structural elucidation, molecular docking, α-amylase and α-glucosidase inhibition studies of 5-amino-nicotinic acid derivatives
por: Nawaz, Muhammad, et al.
Publicado: (2020)

Synthesis, Molecular Docking Analysis and Biological Evaluations of Saccharide-Modified Thiadiazole Sulfonamide Derivatives
por: Zhang, Zuo-Peng, et al.
Publicado: (2021)

Synthesis, biological evaluation, and molecular docking of novel hydroxyzine derivatives as potential AR antagonists
por: Qi, Yueheng, et al.
Publicado: (2022)

Hybrids of 1,4-Quinone with Quinoline Derivatives: Synthesis, Biological Activity, and Molecular Docking with DT-Diaphorase (NQO1)
por: Kadela-Tomanek, Monika, et al.
Publicado: (2022)

Sevanol and Its Analogues: Chemical Synthesis, Biological Effects and Molecular Docking
por: Belozerova, Olga A., et al.
Publicado: (2020)

Cytotoxic effect and molecular docking of 4-ethoxycarbonylmethyl-1-(piperidin-4-ylcarbonyl)-thiosemicarbazide—a novel topoisomerase II inhibitor
por: Siwek, Agata, et al.
Publicado: (2012)

Biological Evaluation and Molecular Docking Studies of Dimethylpyridine Derivatives
por: Świątek, Piotr, et al.
Publicado: (2019)

2-pyrazoline derivatives in neuropharmacology: Synthesis, ADME prediction, molecular docking and in vivo biological evaluation
por: Upadhyay, Savita, et al.
Publicado: (2017)

Synthesis, X-ray Analysis, Biological Evaluation and Molecular Docking Study of New Thiazoline Derivatives
por: Mabkhot, Yahia N., et al.
Publicado: (2019)

New Urea Derivatives as Potential Antimicrobial Agents: Synthesis, Biological Evaluation, and Molecular Docking Studies
por: Patil, Mahadev, et al.
Publicado: (2019)

Novel Pyrimidine Derivatives as Potential Anticancer Agents: Synthesis, Biological Evaluation and Molecular Docking Study
por: Tylińska, Beata, et al.
Publicado: (2021)

Design, synthesis, molecular docking studies and biological evaluation of thiazole carboxamide derivatives as COX inhibitors
por: Hawash, Mohammed, et al.
Publicado: (2023)

Design, synthesis, molecular docking and biological evaluation of new carbazole derivatives as anticancer, and antioxidant agents
por: Çapan, İrfan, et al.
Publicado: (2023)

Synthesis, Molecular Docking, and Biological Evaluation of Novel Anthranilic Acid Hybrid and Its Diamides as Antispasmodics
por: Milusheva, Miglena, et al.
Publicado: (2023)

Synthesis and antibacterial activity of new (2,4-dioxothiazolidin-5-yl/ylidene)acetic acid derivatives with thiazolidine-2,4-dione, rhodanine and 2-thiohydantoin moieties
por: Trotsko, Nazar, et al.
Publicado: (2018)

Structure-based design, synthesis, molecular docking, and biological activities of 2-(3-benzoylphenyl) propanoic acid derivatives as dual mechanism drugs
por: Ahmed, Musa A., et al.
Publicado: (2012)

Synthesis and Anthelmintic Activity of New Thiosemicarbazide Derivatives—A Preliminary Study
por: Dziduch, Katarzyna, et al.
Publicado: (2020)

Semisynthesis, Biological Evaluation and Molecular Docking Studies of Barbatic Acid Derivatives as Novel Diuretic Candidates
por: Yu, Xiang, et al.
Publicado: (2023)

Novel chloroquinoline derivatives incorporating biologically active benzenesulfonamide moiety: synthesis, cytotoxic activity and molecular docking
por: Ghorab, Mostafa M., et al.
Publicado: (2016)

Synthesis, Biological Evaluation, and Molecular Docking Studies of Novel Isatin-Thiazole Derivatives as α-Glucosidase Inhibitors
por: Xie, Zhenzhen, et al.
Publicado: (2017)

Synthesis, Biological Evaluation and Molecular Docking Studies of 5-Indolylmethylen-4-oxo-2-thioxothiazolidine Derivatives
por: Horishny, Volodymyr, et al.
Publicado: (2022)

Novel quercetin and apigenin-acetamide derivatives: design, synthesis, characterization, biological evaluation and molecular docking studies
por: Isika, Daniel, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_623cg4226ofb4c4q45s1onu0cg