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Stress Reactivity, Susceptibility to Hypertension, and Differential Expression of Genes in Hypertensive Compared to Normotensive Patients

Although half of hypertensive patients have hypertensive parents, known hypertension-related human loci identified by genome-wide analysis explain only 3% of hypertension heredity. Therefore, mainstream transcriptome profiling of hypertensive subjects addresses differentially expressed genes (DEGs)...

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Autores principales: Oshchepkov, Dmitry, Chadaeva, Irina, Kozhemyakina, Rimma, Zolotareva, Karina, Khandaev, Bato, Sharypova, Ekaterina, Ponomarenko, Petr, Bogomolov, Anton, Klimova, Natalya V., Shikhevich, Svetlana, Redina, Olga, Kolosova, Nataliya G., Nazarenko, Maria, Kolchanov, Nikolay A., Markel, Arcady, Ponomarenko, Mikhail
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8911431/
https://www.ncbi.nlm.nih.gov/pubmed/35269977
http://dx.doi.org/10.3390/ijms23052835
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author Oshchepkov, Dmitry
Chadaeva, Irina
Kozhemyakina, Rimma
Zolotareva, Karina
Khandaev, Bato
Sharypova, Ekaterina
Ponomarenko, Petr
Bogomolov, Anton
Klimova, Natalya V.
Shikhevich, Svetlana
Redina, Olga
Kolosova, Nataliya G.
Nazarenko, Maria
Kolchanov, Nikolay A.
Markel, Arcady
Ponomarenko, Mikhail
author_facet Oshchepkov, Dmitry
Chadaeva, Irina
Kozhemyakina, Rimma
Zolotareva, Karina
Khandaev, Bato
Sharypova, Ekaterina
Ponomarenko, Petr
Bogomolov, Anton
Klimova, Natalya V.
Shikhevich, Svetlana
Redina, Olga
Kolosova, Nataliya G.
Nazarenko, Maria
Kolchanov, Nikolay A.
Markel, Arcady
Ponomarenko, Mikhail
author_sort Oshchepkov, Dmitry
collection PubMed
description Although half of hypertensive patients have hypertensive parents, known hypertension-related human loci identified by genome-wide analysis explain only 3% of hypertension heredity. Therefore, mainstream transcriptome profiling of hypertensive subjects addresses differentially expressed genes (DEGs) specific to gender, age, and comorbidities in accordance with predictive preventive personalized participatory medicine treating patients according to their symptoms, individual lifestyle, and genetic background. Within this mainstream paradigm, here, we determined whether, among the known hypertension-related DEGs that we could find, there is any genome-wide hypertension theranostic molecular marker applicable to everyone, everywhere, anytime. Therefore, we sequenced the hippocampal transcriptome of tame and aggressive rats, corresponding to low and high stress reactivity, an increase of which raises hypertensive risk; we identified stress-reactivity-related rat DEGs and compared them with their known homologous hypertension-related animal DEGs. This yielded significant correlations between stress reactivity-related and hypertension-related fold changes (log2 values) of these DEG homologs. We found principal components, PC1 and PC2, corresponding to a half-difference and half-sum of these log2 values. Using the DEGs of hypertensive versus normotensive patients (as the control), we verified the correlations and principal components. This analysis highlighted downregulation of β-protocadherins and hemoglobin as whole-genome hypertension theranostic molecular markers associated with a wide vascular inner diameter and low blood viscosity, respectively.
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spelling pubmed-89114312022-03-11 Stress Reactivity, Susceptibility to Hypertension, and Differential Expression of Genes in Hypertensive Compared to Normotensive Patients Oshchepkov, Dmitry Chadaeva, Irina Kozhemyakina, Rimma Zolotareva, Karina Khandaev, Bato Sharypova, Ekaterina Ponomarenko, Petr Bogomolov, Anton Klimova, Natalya V. Shikhevich, Svetlana Redina, Olga Kolosova, Nataliya G. Nazarenko, Maria Kolchanov, Nikolay A. Markel, Arcady Ponomarenko, Mikhail Int J Mol Sci Article Although half of hypertensive patients have hypertensive parents, known hypertension-related human loci identified by genome-wide analysis explain only 3% of hypertension heredity. Therefore, mainstream transcriptome profiling of hypertensive subjects addresses differentially expressed genes (DEGs) specific to gender, age, and comorbidities in accordance with predictive preventive personalized participatory medicine treating patients according to their symptoms, individual lifestyle, and genetic background. Within this mainstream paradigm, here, we determined whether, among the known hypertension-related DEGs that we could find, there is any genome-wide hypertension theranostic molecular marker applicable to everyone, everywhere, anytime. Therefore, we sequenced the hippocampal transcriptome of tame and aggressive rats, corresponding to low and high stress reactivity, an increase of which raises hypertensive risk; we identified stress-reactivity-related rat DEGs and compared them with their known homologous hypertension-related animal DEGs. This yielded significant correlations between stress reactivity-related and hypertension-related fold changes (log2 values) of these DEG homologs. We found principal components, PC1 and PC2, corresponding to a half-difference and half-sum of these log2 values. Using the DEGs of hypertensive versus normotensive patients (as the control), we verified the correlations and principal components. This analysis highlighted downregulation of β-protocadherins and hemoglobin as whole-genome hypertension theranostic molecular markers associated with a wide vascular inner diameter and low blood viscosity, respectively. MDPI 2022-03-04 /pmc/articles/PMC8911431/ /pubmed/35269977 http://dx.doi.org/10.3390/ijms23052835 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Oshchepkov, Dmitry
Chadaeva, Irina
Kozhemyakina, Rimma
Zolotareva, Karina
Khandaev, Bato
Sharypova, Ekaterina
Ponomarenko, Petr
Bogomolov, Anton
Klimova, Natalya V.
Shikhevich, Svetlana
Redina, Olga
Kolosova, Nataliya G.
Nazarenko, Maria
Kolchanov, Nikolay A.
Markel, Arcady
Ponomarenko, Mikhail
Stress Reactivity, Susceptibility to Hypertension, and Differential Expression of Genes in Hypertensive Compared to Normotensive Patients
title Stress Reactivity, Susceptibility to Hypertension, and Differential Expression of Genes in Hypertensive Compared to Normotensive Patients
title_full Stress Reactivity, Susceptibility to Hypertension, and Differential Expression of Genes in Hypertensive Compared to Normotensive Patients
title_fullStr Stress Reactivity, Susceptibility to Hypertension, and Differential Expression of Genes in Hypertensive Compared to Normotensive Patients
title_full_unstemmed Stress Reactivity, Susceptibility to Hypertension, and Differential Expression of Genes in Hypertensive Compared to Normotensive Patients
title_short Stress Reactivity, Susceptibility to Hypertension, and Differential Expression of Genes in Hypertensive Compared to Normotensive Patients
title_sort stress reactivity, susceptibility to hypertension, and differential expression of genes in hypertensive compared to normotensive patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8911431/
https://www.ncbi.nlm.nih.gov/pubmed/35269977
http://dx.doi.org/10.3390/ijms23052835
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