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Thyroid Function Alteration in Obesity and the Effect of Bariatric Surgery
The most common endocrine disease in obesity is hypothyroidism and secondary endocrine alterations, including abnormal thyroid function, are frequent in obesity. It is unclear whether impaired thyroid function is the cause or the consequence of increased adiposity; furthermore, there are no clear da...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8911439/ https://www.ncbi.nlm.nih.gov/pubmed/35268429 http://dx.doi.org/10.3390/jcm11051340 |
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author | Cordido, María Juiz-Valiña, Paula Urones, Paula Sangiao-Alvarellos, Susana Cordido, Fernando |
author_facet | Cordido, María Juiz-Valiña, Paula Urones, Paula Sangiao-Alvarellos, Susana Cordido, Fernando |
author_sort | Cordido, María |
collection | PubMed |
description | The most common endocrine disease in obesity is hypothyroidism and secondary endocrine alterations, including abnormal thyroid function, are frequent in obesity. It is unclear whether impaired thyroid function is the cause or the consequence of increased adiposity; furthermore, there are no clear data regarding the best way to dose levothyroxine for patients with both hypothyroidism and obesity, and the effect of bariatric surgery (BS). The aim of the present article is to review some controversial aspects of the relation between obesity and the thyroid: (1) Thyroid function in obesity and the effect of BS (2) Thyroid hormone treatment (THT) in obese patients with hypothyroidism and the effect of BS. In summary: In morbidly obese patients, TSH is moderately increased. Morbid obesity has a mild central resistance to the thyroid hormone, reversible with weight loss. In morbidly obese hypothyroid patients, following weight loss, the levothyroxine dose/kg of ideal weight did not change, albeit there was an increment in the levothyroxine dose/kg of actual weight. From a clinical practice perspective, in morbid obesity, diagnosing mild hypothyroidism is difficult, BS improves the altered thyroid function and THT can be adapted better if it is based on ideal weight. |
format | Online Article Text |
id | pubmed-8911439 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-89114392022-03-11 Thyroid Function Alteration in Obesity and the Effect of Bariatric Surgery Cordido, María Juiz-Valiña, Paula Urones, Paula Sangiao-Alvarellos, Susana Cordido, Fernando J Clin Med Review The most common endocrine disease in obesity is hypothyroidism and secondary endocrine alterations, including abnormal thyroid function, are frequent in obesity. It is unclear whether impaired thyroid function is the cause or the consequence of increased adiposity; furthermore, there are no clear data regarding the best way to dose levothyroxine for patients with both hypothyroidism and obesity, and the effect of bariatric surgery (BS). The aim of the present article is to review some controversial aspects of the relation between obesity and the thyroid: (1) Thyroid function in obesity and the effect of BS (2) Thyroid hormone treatment (THT) in obese patients with hypothyroidism and the effect of BS. In summary: In morbidly obese patients, TSH is moderately increased. Morbid obesity has a mild central resistance to the thyroid hormone, reversible with weight loss. In morbidly obese hypothyroid patients, following weight loss, the levothyroxine dose/kg of ideal weight did not change, albeit there was an increment in the levothyroxine dose/kg of actual weight. From a clinical practice perspective, in morbid obesity, diagnosing mild hypothyroidism is difficult, BS improves the altered thyroid function and THT can be adapted better if it is based on ideal weight. MDPI 2022-02-28 /pmc/articles/PMC8911439/ /pubmed/35268429 http://dx.doi.org/10.3390/jcm11051340 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Cordido, María Juiz-Valiña, Paula Urones, Paula Sangiao-Alvarellos, Susana Cordido, Fernando Thyroid Function Alteration in Obesity and the Effect of Bariatric Surgery |
title | Thyroid Function Alteration in Obesity and the Effect of Bariatric Surgery |
title_full | Thyroid Function Alteration in Obesity and the Effect of Bariatric Surgery |
title_fullStr | Thyroid Function Alteration in Obesity and the Effect of Bariatric Surgery |
title_full_unstemmed | Thyroid Function Alteration in Obesity and the Effect of Bariatric Surgery |
title_short | Thyroid Function Alteration in Obesity and the Effect of Bariatric Surgery |
title_sort | thyroid function alteration in obesity and the effect of bariatric surgery |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8911439/ https://www.ncbi.nlm.nih.gov/pubmed/35268429 http://dx.doi.org/10.3390/jcm11051340 |
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