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Treatment of Infection-Related Non-Unions with Bioactive Glass—A Promising Approach or Just Another Method of Dead Space Management?

The treatment of infected and non-infected non-unions remains a major challenge in trauma surgery. Due to the limited availability of autologous bone grafts and the need for local anti-infective treatment, bone substitutes have been the focus of tissue engineering for years. In this context, bioacti...

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Autores principales: Freischmidt, Holger, Armbruster, Jonas, Rothhaas, Catharina, Titze, Nadine, Guehring, Thorsten, Nurjadi, Dennis, Sonntag, Robert, Schmidmaier, Gerhard, Grützner, Paul Alfred, Helbig, Lars
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8911496/
https://www.ncbi.nlm.nih.gov/pubmed/35268930
http://dx.doi.org/10.3390/ma15051697
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author Freischmidt, Holger
Armbruster, Jonas
Rothhaas, Catharina
Titze, Nadine
Guehring, Thorsten
Nurjadi, Dennis
Sonntag, Robert
Schmidmaier, Gerhard
Grützner, Paul Alfred
Helbig, Lars
author_facet Freischmidt, Holger
Armbruster, Jonas
Rothhaas, Catharina
Titze, Nadine
Guehring, Thorsten
Nurjadi, Dennis
Sonntag, Robert
Schmidmaier, Gerhard
Grützner, Paul Alfred
Helbig, Lars
author_sort Freischmidt, Holger
collection PubMed
description The treatment of infected and non-infected non-unions remains a major challenge in trauma surgery. Due to the limited availability of autologous bone grafts and the need for local anti-infective treatment, bone substitutes have been the focus of tissue engineering for years. In this context, bioactive glasses are promising, especially regarding their anti-infective potential, which could reduce the need for local and systemic treatment with conventional antibiotics. The aim of this study was to investigate the osteoinductive and osteoconductive effects, as well as the anti-infectious potential, of S53P4 using a standardized non-union model, which had not been investigated previously. Using an already established sequential animal model in infected and non-infected rat femora, we were able to investigate bioactive glass S53P4 under realistic non-union conditions regarding its osteoinductive, osteoconductive and anti-infective potential with the use of µCT scans, biomechanical testing and histological, as well as microbiological, analysis. Although S53P4 did not lead to a stable union in the non-infected or the infected setting, µCT analysis revealed an osteoinductive effect of S53P4 under non-infected conditions, which was diminished under infected conditions. The osteoconductive effect of S53P4 remained almost negligible in histological analysis, even 8 weeks after treatment. Additionally, the expected anti-infective effect could not be demonstrated. Our data suggested that S53P4 should not be used in infected non-unions, especially in those with large bone defects.
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spelling pubmed-89114962022-03-11 Treatment of Infection-Related Non-Unions with Bioactive Glass—A Promising Approach or Just Another Method of Dead Space Management? Freischmidt, Holger Armbruster, Jonas Rothhaas, Catharina Titze, Nadine Guehring, Thorsten Nurjadi, Dennis Sonntag, Robert Schmidmaier, Gerhard Grützner, Paul Alfred Helbig, Lars Materials (Basel) Article The treatment of infected and non-infected non-unions remains a major challenge in trauma surgery. Due to the limited availability of autologous bone grafts and the need for local anti-infective treatment, bone substitutes have been the focus of tissue engineering for years. In this context, bioactive glasses are promising, especially regarding their anti-infective potential, which could reduce the need for local and systemic treatment with conventional antibiotics. The aim of this study was to investigate the osteoinductive and osteoconductive effects, as well as the anti-infectious potential, of S53P4 using a standardized non-union model, which had not been investigated previously. Using an already established sequential animal model in infected and non-infected rat femora, we were able to investigate bioactive glass S53P4 under realistic non-union conditions regarding its osteoinductive, osteoconductive and anti-infective potential with the use of µCT scans, biomechanical testing and histological, as well as microbiological, analysis. Although S53P4 did not lead to a stable union in the non-infected or the infected setting, µCT analysis revealed an osteoinductive effect of S53P4 under non-infected conditions, which was diminished under infected conditions. The osteoconductive effect of S53P4 remained almost negligible in histological analysis, even 8 weeks after treatment. Additionally, the expected anti-infective effect could not be demonstrated. Our data suggested that S53P4 should not be used in infected non-unions, especially in those with large bone defects. MDPI 2022-02-24 /pmc/articles/PMC8911496/ /pubmed/35268930 http://dx.doi.org/10.3390/ma15051697 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Freischmidt, Holger
Armbruster, Jonas
Rothhaas, Catharina
Titze, Nadine
Guehring, Thorsten
Nurjadi, Dennis
Sonntag, Robert
Schmidmaier, Gerhard
Grützner, Paul Alfred
Helbig, Lars
Treatment of Infection-Related Non-Unions with Bioactive Glass—A Promising Approach or Just Another Method of Dead Space Management?
title Treatment of Infection-Related Non-Unions with Bioactive Glass—A Promising Approach or Just Another Method of Dead Space Management?
title_full Treatment of Infection-Related Non-Unions with Bioactive Glass—A Promising Approach or Just Another Method of Dead Space Management?
title_fullStr Treatment of Infection-Related Non-Unions with Bioactive Glass—A Promising Approach or Just Another Method of Dead Space Management?
title_full_unstemmed Treatment of Infection-Related Non-Unions with Bioactive Glass—A Promising Approach or Just Another Method of Dead Space Management?
title_short Treatment of Infection-Related Non-Unions with Bioactive Glass—A Promising Approach or Just Another Method of Dead Space Management?
title_sort treatment of infection-related non-unions with bioactive glass—a promising approach or just another method of dead space management?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8911496/
https://www.ncbi.nlm.nih.gov/pubmed/35268930
http://dx.doi.org/10.3390/ma15051697
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