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CXCL10/IP10 as a Biomarker Linking Multisystem Inflammatory Syndrome and Left Ventricular Dysfunction in Children with SARS-CoV-2

Background: To investigate the diagnostic accuracy of CXCL10/IP10 for left ventricular (LV) dysfunction in multisystemic inflammatory syndrome (MIS-C). Methods: This cross-sectional, longitudinal study included 36 patients with MIS-C. Patients were classified as follows: (1) patients presenting with...

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Autores principales: Başar, Eviç Zeynep, Sönmez, Hafize Emine, Uzuner, Hüseyin, Karadenizli, Aynur, Güngör, Hüseyin Salih, Akgün, Gökmen, Yetimakman, Ayşe Filiz, Öncel, Selim, Babaoğlu, Kadir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8911504/
https://www.ncbi.nlm.nih.gov/pubmed/35268506
http://dx.doi.org/10.3390/jcm11051416
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author Başar, Eviç Zeynep
Sönmez, Hafize Emine
Uzuner, Hüseyin
Karadenizli, Aynur
Güngör, Hüseyin Salih
Akgün, Gökmen
Yetimakman, Ayşe Filiz
Öncel, Selim
Babaoğlu, Kadir
author_facet Başar, Eviç Zeynep
Sönmez, Hafize Emine
Uzuner, Hüseyin
Karadenizli, Aynur
Güngör, Hüseyin Salih
Akgün, Gökmen
Yetimakman, Ayşe Filiz
Öncel, Selim
Babaoğlu, Kadir
author_sort Başar, Eviç Zeynep
collection PubMed
description Background: To investigate the diagnostic accuracy of CXCL10/IP10 for left ventricular (LV) dysfunction in multisystemic inflammatory syndrome (MIS-C). Methods: This cross-sectional, longitudinal study included 36 patients with MIS-C. Patients were classified as follows: (1) patients presenting with Kawasaki-like features (group I = 11); (2) patients presenting with LV systolic dysfunction (group II = 9); and (3) other presentations (group III = 3). CXCL10/IP10 levels were measured upon admission and on days 3 and 7 of treatment. Results: Twenty patients were male and 16 were female. The median age of patients at diagnosis was 7.5 (1.5–17) years. All patients had a fever lasting for a median of 4 (2–7) days. Ten patients had LV systolic dysfunction. The duration of hospitalization was longer in group II. Lymphocyte and platelet counts were lower, whereas NT-pro-BNP, troponin-I, D-dimer, and CXCL10/IP10 levels were higher in group II. Baseline levels of CXCL10/IP10 were weakly negatively correlated with ejection fraction (r = −0.387, p = 0.022). Receiver operator characteristic curve analysis yielded a cutoff value of CXCL10/IP10 to discriminate patients with LV dysfunction was 1839 pg/mL with sensitivity 88% and specificity 68% (Area under curve (AUC) = 0.827, 95% CI 0.682–0.972, p = 0.003). Conclusion: Having a good correlation with cardiac function, CXCL10/IP10 is a potential biomarker to predict LV dysfunction in MIS-C patients.
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spelling pubmed-89115042022-03-11 CXCL10/IP10 as a Biomarker Linking Multisystem Inflammatory Syndrome and Left Ventricular Dysfunction in Children with SARS-CoV-2 Başar, Eviç Zeynep Sönmez, Hafize Emine Uzuner, Hüseyin Karadenizli, Aynur Güngör, Hüseyin Salih Akgün, Gökmen Yetimakman, Ayşe Filiz Öncel, Selim Babaoğlu, Kadir J Clin Med Article Background: To investigate the diagnostic accuracy of CXCL10/IP10 for left ventricular (LV) dysfunction in multisystemic inflammatory syndrome (MIS-C). Methods: This cross-sectional, longitudinal study included 36 patients with MIS-C. Patients were classified as follows: (1) patients presenting with Kawasaki-like features (group I = 11); (2) patients presenting with LV systolic dysfunction (group II = 9); and (3) other presentations (group III = 3). CXCL10/IP10 levels were measured upon admission and on days 3 and 7 of treatment. Results: Twenty patients were male and 16 were female. The median age of patients at diagnosis was 7.5 (1.5–17) years. All patients had a fever lasting for a median of 4 (2–7) days. Ten patients had LV systolic dysfunction. The duration of hospitalization was longer in group II. Lymphocyte and platelet counts were lower, whereas NT-pro-BNP, troponin-I, D-dimer, and CXCL10/IP10 levels were higher in group II. Baseline levels of CXCL10/IP10 were weakly negatively correlated with ejection fraction (r = −0.387, p = 0.022). Receiver operator characteristic curve analysis yielded a cutoff value of CXCL10/IP10 to discriminate patients with LV dysfunction was 1839 pg/mL with sensitivity 88% and specificity 68% (Area under curve (AUC) = 0.827, 95% CI 0.682–0.972, p = 0.003). Conclusion: Having a good correlation with cardiac function, CXCL10/IP10 is a potential biomarker to predict LV dysfunction in MIS-C patients. MDPI 2022-03-04 /pmc/articles/PMC8911504/ /pubmed/35268506 http://dx.doi.org/10.3390/jcm11051416 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Başar, Eviç Zeynep
Sönmez, Hafize Emine
Uzuner, Hüseyin
Karadenizli, Aynur
Güngör, Hüseyin Salih
Akgün, Gökmen
Yetimakman, Ayşe Filiz
Öncel, Selim
Babaoğlu, Kadir
CXCL10/IP10 as a Biomarker Linking Multisystem Inflammatory Syndrome and Left Ventricular Dysfunction in Children with SARS-CoV-2
title CXCL10/IP10 as a Biomarker Linking Multisystem Inflammatory Syndrome and Left Ventricular Dysfunction in Children with SARS-CoV-2
title_full CXCL10/IP10 as a Biomarker Linking Multisystem Inflammatory Syndrome and Left Ventricular Dysfunction in Children with SARS-CoV-2
title_fullStr CXCL10/IP10 as a Biomarker Linking Multisystem Inflammatory Syndrome and Left Ventricular Dysfunction in Children with SARS-CoV-2
title_full_unstemmed CXCL10/IP10 as a Biomarker Linking Multisystem Inflammatory Syndrome and Left Ventricular Dysfunction in Children with SARS-CoV-2
title_short CXCL10/IP10 as a Biomarker Linking Multisystem Inflammatory Syndrome and Left Ventricular Dysfunction in Children with SARS-CoV-2
title_sort cxcl10/ip10 as a biomarker linking multisystem inflammatory syndrome and left ventricular dysfunction in children with sars-cov-2
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8911504/
https://www.ncbi.nlm.nih.gov/pubmed/35268506
http://dx.doi.org/10.3390/jcm11051416
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