Cargando…

Heat Shock Proteins Alterations in Rheumatoid Arthritis

Rheumatoid arthritis (RA) is a chronic inflammatory and autoimmune disease characterized by the attack of the immune system on the body’s healthy joint lining and degeneration of articular structures. This disease involves an increased release of inflammatory mediators in the affected joint that sen...

Descripción completa

Detalles Bibliográficos
Autores principales: Fouani, Malak, Basset, Charbel A., Mangano, Giuseppe D., Leone, Lavinia G., Lawand, Nada B., Leone, Angelo, Barone, Rosario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8911505/
https://www.ncbi.nlm.nih.gov/pubmed/35269948
http://dx.doi.org/10.3390/ijms23052806
_version_ 1784666827623759872
author Fouani, Malak
Basset, Charbel A.
Mangano, Giuseppe D.
Leone, Lavinia G.
Lawand, Nada B.
Leone, Angelo
Barone, Rosario
author_facet Fouani, Malak
Basset, Charbel A.
Mangano, Giuseppe D.
Leone, Lavinia G.
Lawand, Nada B.
Leone, Angelo
Barone, Rosario
author_sort Fouani, Malak
collection PubMed
description Rheumatoid arthritis (RA) is a chronic inflammatory and autoimmune disease characterized by the attack of the immune system on the body’s healthy joint lining and degeneration of articular structures. This disease involves an increased release of inflammatory mediators in the affected joint that sensitize sensory neurons and create a positive feedback loop to further enhance their release. Among these mediators, the cytokines and neuropeptides are responsible for the crippling pain and the persistent neurogenic inflammation associated with RA. More importantly, specific proteins released either centrally or peripherally have been shown to play opposing roles in the pathogenesis of this disease: an inflammatory role that mediates and increases the severity of inflammatory response and/or an anti-inflammatory and protective role that modulates the process of inflammation. In this review, we will shed light on the neuroimmune function of different members of the heat shock protein (HSPs) family and the complex manifold actions that they exert during the course of RA. Specifically, we will focus our discussion on the duality in the mechanism of action of Hsp27, Hsp60, Hsp70, and Hsp90.
format Online
Article
Text
id pubmed-8911505
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-89115052022-03-11 Heat Shock Proteins Alterations in Rheumatoid Arthritis Fouani, Malak Basset, Charbel A. Mangano, Giuseppe D. Leone, Lavinia G. Lawand, Nada B. Leone, Angelo Barone, Rosario Int J Mol Sci Review Rheumatoid arthritis (RA) is a chronic inflammatory and autoimmune disease characterized by the attack of the immune system on the body’s healthy joint lining and degeneration of articular structures. This disease involves an increased release of inflammatory mediators in the affected joint that sensitize sensory neurons and create a positive feedback loop to further enhance their release. Among these mediators, the cytokines and neuropeptides are responsible for the crippling pain and the persistent neurogenic inflammation associated with RA. More importantly, specific proteins released either centrally or peripherally have been shown to play opposing roles in the pathogenesis of this disease: an inflammatory role that mediates and increases the severity of inflammatory response and/or an anti-inflammatory and protective role that modulates the process of inflammation. In this review, we will shed light on the neuroimmune function of different members of the heat shock protein (HSPs) family and the complex manifold actions that they exert during the course of RA. Specifically, we will focus our discussion on the duality in the mechanism of action of Hsp27, Hsp60, Hsp70, and Hsp90. MDPI 2022-03-03 /pmc/articles/PMC8911505/ /pubmed/35269948 http://dx.doi.org/10.3390/ijms23052806 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Fouani, Malak
Basset, Charbel A.
Mangano, Giuseppe D.
Leone, Lavinia G.
Lawand, Nada B.
Leone, Angelo
Barone, Rosario
Heat Shock Proteins Alterations in Rheumatoid Arthritis
title Heat Shock Proteins Alterations in Rheumatoid Arthritis
title_full Heat Shock Proteins Alterations in Rheumatoid Arthritis
title_fullStr Heat Shock Proteins Alterations in Rheumatoid Arthritis
title_full_unstemmed Heat Shock Proteins Alterations in Rheumatoid Arthritis
title_short Heat Shock Proteins Alterations in Rheumatoid Arthritis
title_sort heat shock proteins alterations in rheumatoid arthritis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8911505/
https://www.ncbi.nlm.nih.gov/pubmed/35269948
http://dx.doi.org/10.3390/ijms23052806
work_keys_str_mv AT fouanimalak heatshockproteinsalterationsinrheumatoidarthritis
AT bassetcharbela heatshockproteinsalterationsinrheumatoidarthritis
AT manganogiusepped heatshockproteinsalterationsinrheumatoidarthritis
AT leonelaviniag heatshockproteinsalterationsinrheumatoidarthritis
AT lawandnadab heatshockproteinsalterationsinrheumatoidarthritis
AT leoneangelo heatshockproteinsalterationsinrheumatoidarthritis
AT baronerosario heatshockproteinsalterationsinrheumatoidarthritis