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New Pharmacological Strategies against Pancreatic Adenocarcinoma: The Multifunctional Thiosemicarbazone FA4

A new sigma-2 (σ2) receptor ligand (FA4) was efficiently synthesized and evaluated for cytotoxic, proapoptotic, and antimigratory activity on pancreatic ductal adenocarcinoma (PDAC) primary cell cultures, which restrained the aggressive and chemoresistant behavior of PDAC. This compound showed relev...

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Detalles Bibliográficos
Autores principales:	Anobile, Dario P., Niso, Mauro, Puerta, Adrian, Fraga Rodrigues, Stephanie M., Abatematteo, Francesca S., Avan, Amir, Abate, Carmen, Riganti, Chiara, Giovannetti, Elisa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8911630/ https://www.ncbi.nlm.nih.gov/pubmed/35268783 http://dx.doi.org/10.3390/molecules27051682

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