Cargando…

The Highly Efficient Synthesis of 1,2-Disubstituted Benzimidazoles Using Microwave Irradiation

The benzimidazole ring of the heterocyclic pharmacophores is one of the most widespread and studied systems in nature. The benzimidazole derivative synthesis study is a crucial point for the development of a clinically available benzimidazole-based drug. Here, we report a simple microwave assisted m...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nardi, Monica, Bonacci, Sonia, Herrera Cano, Natividad, Oliverio, Manuela, Procopio, Antonio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8911685/ https://www.ncbi.nlm.nih.gov/pubmed/35268852 http://dx.doi.org/10.3390/molecules27051751

Ejemplares similares

Green Synthesis of Privileged Benzimidazole Scaffolds Using Active Deep Eutectic Solvent
por: Di Gioia, Maria Luisa, et al.
Publicado: (2019)

Combined Ultrasound/Microwave Chemocatalytic Method for Selective Conversion of Cellulose into Lactic Acid
por: Tallarico, Sofia, et al.
Publicado: (2019)

Selective and eco-friendly procedures for the synthesis of benzimidazole derivatives. The role of the Er(OTf)(3) catalyst in the reaction selectivity
por: Herrera Cano, Natividad, et al.
Publicado: (2016)

Storage Effects on Bioactive Phenols in Calabrian Monovarietal Extra Virgin Olive Oils Based on the EFSA Health Claim
por: Frisina, Marialaura, et al.
Publicado: (2023)

Tunable microwave-assisted method for the solvent-free and catalyst-free peracetylation of natural products
por: Oliverio, Manuela, et al.
Publicado: (2016)

Iron-Catalyzed Acceptorless Dehydrogenative Coupling of Alcohols With Aromatic Diamines: Selective Synthesis of 1,2-Disubstituted Benzimidazoles
por: Putta, Ramachandra Reddy, et al.
Publicado: (2020)

Functional Compounds of Cold-Pressed Pomegranate Seed Oil: Fatty Acids and Phytosterols Profile as Quality Biomarkers for Origin Discrimination
por: Iriti, Giuseppe, et al.
Publicado: (2023)

Non-Conventional Methodologies in the Synthesis of 1-Indanones
por: Oliverio, Manuela, et al.
Publicado: (2014)

Synthesis and Antimycobacterial Activity of 2,5-Disubstituted and 1,2,5-Trisubstituted Benzimidazoles
por: Jiménez-Juárez, Rogelio, et al.
Publicado: (2020)

A Bioinspired Catalytic Aerobic Oxidative C–H Functionalization of Primary Aliphatic Amines: Synthesis of 1,2-Disubstituted Benzimidazoles
por: Nguyen, Khac Minh Huy, et al.
Publicado: (2015)

Targeting Receptor Tyrosine Kinase VEGFR-2 in Hepatocellular Cancer: Rational Design, Synthesis and Biological Evaluation of 1,2-Disubstituted Benzimidazoles
por: Abdel-Mohsen, Heba T., et al.
Publicado: (2020)

Structure-based design of functionalized 2-substituted and 1,2-disubstituted benzimidazole derivatives and their in vitro antibacterial efficacy
por: Ajani, Olayinka O., et al.
Publicado: (2017)

Enantioselective Synthesis of 1,12‐Disubstituted [4]Helicenes
por: Hartung, Thierry, et al.
Publicado: (2020)

Novel Hydroxytyrosol-Donepezil Hybrids as Potential Antioxidant and Neuroprotective Agents
por: Costanzo, Paola, et al.
Publicado: (2021)

An Erbium-Based Bifuctional Heterogeneous Catalyst: A Cooperative Route Towards C-C Bond Formation
por: Oliverio, Manuela, et al.
Publicado: (2014)

An Efficient Synthesis of Pyridoxal Oxime Derivatives under Microwave Irradiation
por: Gašo-Sokač, Dajana, et al.
Publicado: (2014)

Biological Activity of Newly Synthesized Benzimidazole and Benzothizole 2,5-Disubstituted Furane Derivatives
por: Racané, Livio, et al.
Publicado: (2021)

Synthesis of 1,2-Disubstituted Adamantane Derivatives by Construction of the Adamantane Framework †
por: Todd, Matthew, et al.
Publicado: (2023)

Microwave-Assisted Synthesis of Mono- and Disubstituted 4-Hydroxyacetophenone Derivatives via Mannich Reaction: Synthesis, XRD and HS-Analysis
por: Aljohani, Ghadah, et al.
Publicado: (2019)

Biorenewable Deep Eutectic Solvent for Selective and Scalable Conversion of Furfural into Cyclopentenone Derivatives
por: Di Gioia, Maria Luisa, et al.
Publicado: (2018)

Efficient Synthesis of Boron-Containing α-Acyloxyamide Analogs via Microwave Irradiation
por: Chai, Chih-Cheng, et al.
Publicado: (2013)

Halide-Mediated Ortho-Deprotonation Reactions Applied to the Synthesis of 1,2- and 1,3-Disubstituted Ferrocene Derivatives
por: Zirakzadeh, Afrooz, et al.
Publicado: (2015)

Three-component microwave-assisted synthesis of 3,5-disubstituted pyrazolo[3,4-d]pyrimidin-4-ones
por: Ng, Jia Hui, et al.
Publicado: (2022)

Efficient One-Pot, Two-Component Modular Synthesis of 3,5-Disubstituted Pyrazoles
por: Mohamady, Samy, et al.
Publicado: (2018)

Synthesis of 2,6-disubstituted tetrahydroazulene derivatives
por: Hussain, Zakir, et al.
Publicado: (2012)

Stereoselective Synthesis of α-Disubstituted β-Homoprolines
por: Quintavalla, Arianna, et al.
Publicado: (2023)

Rhodium-Catalyzed Synthesis of 2,3-Disubstituted Indoles from β,β-Disubstituted Stryryl Azides**
por: Sun, Ke, et al.
Publicado: (2011)

The Double-Edged Sword of Oleuropein in Ovarian Cancer Cells: From Antioxidant Functions to Cytotoxic Effects
por: Scicchitano, Stefania, et al.
Publicado: (2023)

Pyrimido[1,2-a]benzimidazoles: synthesis and perspective of their pharmacological use
por: Fedotov, Victor V., et al.
Publicado: (2021)

Comparative Studies on Conventional and Microwave Synthesis of Some Benzimidazole, Benzothiazole and Indole Derivatives and Testing on Inhibition of Hyaluronidase
por: Algul, Oztekin, et al.
Publicado: (2008)

A New and Efficient Method for the Synthesis of 3,4-Disubstituted Pyrrolidine-2,5-diones
por: Ilieva, Eleonora D., et al.
Publicado: (2012)

Ni-catalyzed 1,2-benzylboration of 1,2-disubstituted unactivated alkenes
por: Joung, Seewon, et al.
Publicado: (2019)

Highly Efficient Esterification of Ferulic Acid Under Microwave Irradiation
por: Li, Nian-Guang, et al.
Publicado: (2009)

One-Pot Modified Madelung Synthesis of 3-Tosyl- and 3-Cyano-1,2-disubstituted Indoles
por: Sterligov, Grigorii K., et al.
Publicado: (2022)

Facile and efficient one-pot synthesis of benzimidazoles using lanthanum chloride
por: Venkateswarlu, Yekkirala, et al.
Publicado: (2013)

HFIP-Promoted Bischler Indole Synthesis under Microwave Irradiation
por: Yao, Guangkai, et al.
Publicado: (2018)

Natural dolomitic limestone-catalyzed synthesis of benzimidazoles, dihydropyrimidinones, and highly substituted pyridines under ultrasound irradiation
por: Godugu, Kumar, et al.
Publicado: (2020)

Simple two-step synthesis of 2,4-disubstituted pyrroles and 3,5-disubstituted pyrrole-2-carbonitriles from enones
por: Kucukdisli, Murat, et al.
Publicado: (2014)

A Facile and Efficient Procedure for the Synthesis of New Benzimidazole-2-thione Derivatives
por: Rivera, Augusto, et al.
Publicado: (2012)

Synthesis and Antimalarial Activity of 1,4-Disubstituted Piperidine Derivatives
por: Seck, Rokhyatou, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_she9en5g5j87k8lkkft1kqlqj6