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Chemical Composition Analysis, Cytotoxic, Antimicrobial and Antioxidant Activities of Physalis angulata L.: A Comparative Study of Leaves and Fruit
Physalis angulata L. belongs to the family Solanaceae and is distributed throughout the tropical and subtropical regions. Physalis angulata leaf and fruit extracts were assessed for in vitro anticancer, antioxidant activity, and total phenolic and flavonoid content. The GC-MS technique investigated...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8911865/ https://www.ncbi.nlm.nih.gov/pubmed/35268579 http://dx.doi.org/10.3390/molecules27051480 |
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author | Ramakrishna Pillai, Jayachithra Wali, Adil Farooq Menezes, Godfred Antony Rehman, Muneeb U. Wani, Tanveer A. Arafah, Azher Zargar, Seema Mir, Tahir Maqbool |
author_facet | Ramakrishna Pillai, Jayachithra Wali, Adil Farooq Menezes, Godfred Antony Rehman, Muneeb U. Wani, Tanveer A. Arafah, Azher Zargar, Seema Mir, Tahir Maqbool |
author_sort | Ramakrishna Pillai, Jayachithra |
collection | PubMed |
description | Physalis angulata L. belongs to the family Solanaceae and is distributed throughout the tropical and subtropical regions. Physalis angulata leaf and fruit extracts were assessed for in vitro anticancer, antioxidant activity, and total phenolic and flavonoid content. The GC-MS technique investigated the chemical composition and structure of bioactive chemicals reported in extracts. The anticancer activity results revealed a decrease in the percentage of anticancer cells’ viability in a concentration- and time-dependent way. We also noticed morphological alterations in the cells, which we believe are related to Physalis angulata extracts. Under light microscopy, we observed that as the concentration of ethanolic extract (fruit and leaves) treated HeLa cells increased, the number of cells began to decrease. |
format | Online Article Text |
id | pubmed-8911865 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-89118652022-03-11 Chemical Composition Analysis, Cytotoxic, Antimicrobial and Antioxidant Activities of Physalis angulata L.: A Comparative Study of Leaves and Fruit Ramakrishna Pillai, Jayachithra Wali, Adil Farooq Menezes, Godfred Antony Rehman, Muneeb U. Wani, Tanveer A. Arafah, Azher Zargar, Seema Mir, Tahir Maqbool Molecules Article Physalis angulata L. belongs to the family Solanaceae and is distributed throughout the tropical and subtropical regions. Physalis angulata leaf and fruit extracts were assessed for in vitro anticancer, antioxidant activity, and total phenolic and flavonoid content. The GC-MS technique investigated the chemical composition and structure of bioactive chemicals reported in extracts. The anticancer activity results revealed a decrease in the percentage of anticancer cells’ viability in a concentration- and time-dependent way. We also noticed morphological alterations in the cells, which we believe are related to Physalis angulata extracts. Under light microscopy, we observed that as the concentration of ethanolic extract (fruit and leaves) treated HeLa cells increased, the number of cells began to decrease. MDPI 2022-02-22 /pmc/articles/PMC8911865/ /pubmed/35268579 http://dx.doi.org/10.3390/molecules27051480 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Ramakrishna Pillai, Jayachithra Wali, Adil Farooq Menezes, Godfred Antony Rehman, Muneeb U. Wani, Tanveer A. Arafah, Azher Zargar, Seema Mir, Tahir Maqbool Chemical Composition Analysis, Cytotoxic, Antimicrobial and Antioxidant Activities of Physalis angulata L.: A Comparative Study of Leaves and Fruit |
title | Chemical Composition Analysis, Cytotoxic, Antimicrobial and Antioxidant Activities of Physalis angulata L.: A Comparative Study of Leaves and Fruit |
title_full | Chemical Composition Analysis, Cytotoxic, Antimicrobial and Antioxidant Activities of Physalis angulata L.: A Comparative Study of Leaves and Fruit |
title_fullStr | Chemical Composition Analysis, Cytotoxic, Antimicrobial and Antioxidant Activities of Physalis angulata L.: A Comparative Study of Leaves and Fruit |
title_full_unstemmed | Chemical Composition Analysis, Cytotoxic, Antimicrobial and Antioxidant Activities of Physalis angulata L.: A Comparative Study of Leaves and Fruit |
title_short | Chemical Composition Analysis, Cytotoxic, Antimicrobial and Antioxidant Activities of Physalis angulata L.: A Comparative Study of Leaves and Fruit |
title_sort | chemical composition analysis, cytotoxic, antimicrobial and antioxidant activities of physalis angulata l.: a comparative study of leaves and fruit |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8911865/ https://www.ncbi.nlm.nih.gov/pubmed/35268579 http://dx.doi.org/10.3390/molecules27051480 |
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