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Pharmacological Role of Functionalized Gold Nanoparticles in Disease Applications
Gold has always been regarded as a symbol of nobility, and its shiny golden appearance has always attracted the attention of many people. Gold has good ductility, molecular recognition properties, and good biocompatibility. At present, gold is being used in many fields. When gold particles are as sm...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8911979/ https://www.ncbi.nlm.nih.gov/pubmed/35268651 http://dx.doi.org/10.3390/molecules27051551 |
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author | Ko, Wen-Chin Wang, Su-Jane Hsiao, Chien-Yu Hung, Chen-Ting Hsu, Yu-Jou Chang, Der-Chen Hung, Chi-Feng |
author_facet | Ko, Wen-Chin Wang, Su-Jane Hsiao, Chien-Yu Hung, Chen-Ting Hsu, Yu-Jou Chang, Der-Chen Hung, Chi-Feng |
author_sort | Ko, Wen-Chin |
collection | PubMed |
description | Gold has always been regarded as a symbol of nobility, and its shiny golden appearance has always attracted the attention of many people. Gold has good ductility, molecular recognition properties, and good biocompatibility. At present, gold is being used in many fields. When gold particles are as small as several nanometers, their physical and chemical properties vary with their size in nanometers. The surface area of a nano-sized gold surface has a special effect. Therefore, gold nanoparticles can, directly and indirectly, give rise to different biological activities. For example, if the surface of the gold is sulfided. Various substances have a strong chemical reactivity and are easy to combine with sulfhydryl groups; hence, nanogold is often used in biomedical testing, disease diagnosis, and gene detection. Nanogold is easy to bind to proteins, such as antibodies, enzymes, or cytokines. In fact, scientists use nanogold to bind special antibodies, as a tool for targeting cancer cells. Gold nanoparticles are also directly cytotoxic to cancer cells. For diseases caused by inflammation and oxidative damage, gold nanoparticles also have antioxidant and anti-inflammatory effects. Based on these unique properties, gold nanoparticles have become the most widely studied metal nanomaterials. Many recent studies have further demonstrated that gold nanoparticles are beneficial for humans, due to their functional pharmacological properties in a variety of diseases. The content of this review will be the application of gold nanoparticles in treating or diagnosing pressing diseases, such as cancers, retinopathy, neurological diseases, skin disorders, bowel diseases, bone cartilage disorders, cardiovascular diseases, infections, and metabolic syndrome. Gold nanoparticles have shown very obvious therapeutic and application potential. |
format | Online Article Text |
id | pubmed-8911979 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-89119792022-03-11 Pharmacological Role of Functionalized Gold Nanoparticles in Disease Applications Ko, Wen-Chin Wang, Su-Jane Hsiao, Chien-Yu Hung, Chen-Ting Hsu, Yu-Jou Chang, Der-Chen Hung, Chi-Feng Molecules Review Gold has always been regarded as a symbol of nobility, and its shiny golden appearance has always attracted the attention of many people. Gold has good ductility, molecular recognition properties, and good biocompatibility. At present, gold is being used in many fields. When gold particles are as small as several nanometers, their physical and chemical properties vary with their size in nanometers. The surface area of a nano-sized gold surface has a special effect. Therefore, gold nanoparticles can, directly and indirectly, give rise to different biological activities. For example, if the surface of the gold is sulfided. Various substances have a strong chemical reactivity and are easy to combine with sulfhydryl groups; hence, nanogold is often used in biomedical testing, disease diagnosis, and gene detection. Nanogold is easy to bind to proteins, such as antibodies, enzymes, or cytokines. In fact, scientists use nanogold to bind special antibodies, as a tool for targeting cancer cells. Gold nanoparticles are also directly cytotoxic to cancer cells. For diseases caused by inflammation and oxidative damage, gold nanoparticles also have antioxidant and anti-inflammatory effects. Based on these unique properties, gold nanoparticles have become the most widely studied metal nanomaterials. Many recent studies have further demonstrated that gold nanoparticles are beneficial for humans, due to their functional pharmacological properties in a variety of diseases. The content of this review will be the application of gold nanoparticles in treating or diagnosing pressing diseases, such as cancers, retinopathy, neurological diseases, skin disorders, bowel diseases, bone cartilage disorders, cardiovascular diseases, infections, and metabolic syndrome. Gold nanoparticles have shown very obvious therapeutic and application potential. MDPI 2022-02-25 /pmc/articles/PMC8911979/ /pubmed/35268651 http://dx.doi.org/10.3390/molecules27051551 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Ko, Wen-Chin Wang, Su-Jane Hsiao, Chien-Yu Hung, Chen-Ting Hsu, Yu-Jou Chang, Der-Chen Hung, Chi-Feng Pharmacological Role of Functionalized Gold Nanoparticles in Disease Applications |
title | Pharmacological Role of Functionalized Gold Nanoparticles in Disease Applications |
title_full | Pharmacological Role of Functionalized Gold Nanoparticles in Disease Applications |
title_fullStr | Pharmacological Role of Functionalized Gold Nanoparticles in Disease Applications |
title_full_unstemmed | Pharmacological Role of Functionalized Gold Nanoparticles in Disease Applications |
title_short | Pharmacological Role of Functionalized Gold Nanoparticles in Disease Applications |
title_sort | pharmacological role of functionalized gold nanoparticles in disease applications |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8911979/ https://www.ncbi.nlm.nih.gov/pubmed/35268651 http://dx.doi.org/10.3390/molecules27051551 |
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