Cargando…

Plant-Derived Molecule 4-Methylumbelliferone Suppresses FcεRI-Mediated Mast Cell Activation and Allergic Inflammation

Mast cells (MCs) are an important treatment target for high-affinity IgE Fc receptor (FcεRI)-mediated allergic diseases. The plant-derived molecule 4-methylumbelliferone (4-MU) has beneficial effects in animal models of inflammation and autoimmunity diseases. The aim of this study was to examine 4-M...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Hui-Na, Xiang, Qiu-An, Lin, Hao-Hui, Chen, Jie-Ning, Guo, Wen-Jie, Guo, Wan-Meng, Yue, Xiang-Ning, Zhao, Zhen-Fu, Ji, Kunmei, Chen, Jia-Jie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8912031/ https://www.ncbi.nlm.nih.gov/pubmed/35268679 http://dx.doi.org/10.3390/molecules27051577

Ejemplares similares

SG-SP1 Suppresses Mast Cell-Mediated Allergic Inflammation via Inhibition of FcεRI Signaling
por: Kim, Min-Jong, et al.
Publicado: (2020)

New Mechanistic Advances in FcεRI-Mast Cell–Mediated Allergic Signaling
por: Li, Yang, et al.
Publicado: (2022)

FcεRI Signaling in the Modulation of Allergic Response: Role of Mast Cell-Derived Exosomes
por: Lecce, Mario, et al.
Publicado: (2020)

IRF3 Activation in Mast Cells Promotes FcεRI-Mediated Allergic Inflammation
por: Choi, Young-Ae, et al.
Publicado: (2023)

Tespa1 negatively regulates FcεRI-mediated signaling and the mast cell–mediated allergic response
por: Wang, Di, et al.
Publicado: (2014)

Ethanol Inhibits High-Affinity Immunoglobulin E Receptor (FcεRI) Signaling in Mast Cells by Suppressing the Function of FcεRI-Cholesterol Signalosome
por: Draberova, Lubica, et al.
Publicado: (2015)

Eucalyptus oil reduces allergic reactions and suppresses mast cell degranulation by downregulating IgE-FcεRI signalling
por: Nakamura, Tomoya, et al.
Publicado: (2020)

Scrodentoid A Inhibits Mast Cell–Mediated Allergic Response by Blocking the Lyn–FcεRIβ Interaction
por: Qian, Fei, et al.
Publicado: (2019)

FcεRI: A Master Regulator of Mast Cell Functions
por: Nagata, Yuka, et al.
Publicado: (2022)

Cigarette Smoke Suppresses the Surface Expression of c-kit and FcεRI on Mast Cells
por: Givi, M. E., et al.
Publicado: (2013)

Kaempferol Suppresses the Activation of Mast Cells by Modulating the Expression of FcεRI and SHIP1
por: Nagata, Kazuki, et al.
Publicado: (2023)

Observing Fcεri Signaling from the Inside of the Mast Cell Membrane
por: Wilson, Bridget S., et al.
Publicado: (2000)

Fine-Tuning of Mast Cell Activation by FcεRIβ Chain
por: Ra, Chisei, et al.
Publicado: (2012)

The Role Played by Mitochondria in FcεRI-Dependent Mast Cell Activation
por: Chelombitko, Maria A., et al.
Publicado: (2020)

The Crosstalk between FcεRI and Sphingosine Signaling in Allergic Inflammation
por: Jo, Hyein, et al.
Publicado: (2022)

Differential mast cell outcomes are sensitive to FcεRI-Syk binding kinetics
por: Schwartz, Samantha L., et al.
Publicado: (2017)

Corrigendum: The Role Played by Mitochondria in FcϵRI-Dependent Mast Cell Activation
por: Chelombitko, Maria A., et al.
Publicado: (2020)

Rcan1 negatively regulates FcεRI-mediated signaling and mast cell function
por: Yang, Yong Jun, et al.
Publicado: (2009)

Regulation of Trafficking and Signaling of the High Affinity IgE Receptor by FcεRIβ and the Potential Impact of FcεRIβ Splicing in Allergic Inflammation
por: Arthur, Greer K., et al.
Publicado: (2022)

Tim-3 enhances FcεRI-proximal signaling to modulate mast cell activation
por: Phong, Binh L., et al.
Publicado: (2015)

Coaggregation of FcεRI with FcγRIIB Inhibits Degranulation but Not Induction of Bcl-2 Family Members A1 and Bim in Mast Cells
por: Ekoff, Maria, et al.
Publicado: (2006)

Inhibition of MRGPRX2 but not FcεRI or MrgprB2-mediated mast cell degranulation by a small molecule inverse receptor agonist
por: Bawazir, Maram, et al.
Publicado: (2022)

Involvement of Bruton's Tyrosine Kinase in FcεRI-dependent Mast Cell Degranulation and Cytokine Production
por: Hata, Daisuke, et al.
Publicado: (1998)

GRK2 differentially regulates FcεRI and MRGPRB2-mediated responses in mast cells
por: Thapaliya, Monica, et al.
Publicado: (2023)

Antibody to FcεRIα Suppresses Immunoglobulin E Binding to High-Affinity Receptor I in Allergic Inflammation
por: Hong, Jung Yeon, et al.
Publicado: (2016)

SLAP Is a Negative Regulator of FcεRI Receptor-Mediated Signaling and Allergic Response
por: Sharma, Namit, et al.
Publicado: (2019)

Second messenger Ap(4)A polymerizes target protein HINT1 to transduce signals in FcεRI-activated mast cells
por: Yu, Jing, et al.
Publicado: (2019)

An Interaction Library for the FcεRI Signaling Network
por: Chylek, Lily A., et al.
Publicado: (2014)

Identification of 5-Hydroxymethylfurfural (5-HMF) as an Active Component Citrus Jabara That Suppresses FcεRI-Mediated Mast Cell Activation
por: Uchida, Ryota, et al.
Publicado: (2020)

Transcriptional response of human mast cells stimulated via the FcεRI and identification of mast cells as a source of IL-11
por: Sayama, Koichi, et al.
Publicado: (2002)

Overexpression of FcεRI on Bone Marrow Mast Cells, but Not MRGPRX2, in Clonal Mast Cell Disorders With Wasp Venom Anaphylaxis
por: Elst, Jessy, et al.
Publicado: (2022)

High resolution mapping of mast cell membranes reveals primary and secondary domains of FcεRI and LAT
por: Wilson, Bridget S., et al.
Publicado: (2001)

Analysis of TRPV channel activation by stimulation of FCεRI and MRGPR receptors in mouse peritoneal mast cells
por: Solís-López, A., et al.
Publicado: (2017)

Antigen Geometry Tunes Mast Cell Signaling Through Distinct FcεRI Aggregation and Structural Changes
por: Rinaldi, Derek A., et al.
Publicado: (2023)

Current Strategies to Inhibit High Affinity FcεRI-Mediated Signaling for the Treatment of Allergic Disease
por: Gomez, Gregorio
Publicado: (2019)

The Fab fragment of anti-IgE Cε2 domain prevents allergic reactions through interacting with IgE-FcεRIα complex on rat mast cells
por: Hirano, Takao, et al.
Publicado: (2018)

GEF-H1 Transduces FcεRI Signaling in Mast Cells to Activate RhoA and Focal Adhesion Formation during Exocytosis
por: Guo, Yitian, et al.
Publicado: (2023)

Gender-Related Effects of Sex Steroids on Histamine Release and FcεRI Expression in Rat Peritoneal Mast Cells
por: Muñoz-Cruz, Samira, et al.
Publicado: (2015)

Rehmannia Glutinosa Pharmacopuncture Solution Regulates Functional Activation, FcεRI Expression, and Signaling Events in Mast Cells
por: Kang, Kyung-Hwa, et al.
Publicado: (2012)

Orai and TRPC channel characterization in FcεRI‐mediated calcium signaling and mediator secretion in human mast cells
por: Wajdner, Hannah E., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_0bqa1mf88ejocdss4qfteqk16g