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Novel Pomegranate-Nanoparticles Ameliorate Cisplatin-Induced Nephrotoxicity and Improves Cisplatin Anti-Cancer Efficacy in Ehrlich Carcinoma Mice Model

Cisplatin (CISP) is one of the most widely used anti-cancer chemotherapeutic agents with remarkable efficacy against various types of cancers. However, it has been associated with nephrotoxicity amongst other undesirable side effects. Pomegranate (PE) is a potent antioxidant and anti-inflammatory ag...

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Autores principales: Harakeh, Steve, Almuhayawi, Mohammed S., Akefe, Isaac O., Saber, Saber H., Al Jaouni, Soad K., Alzughaibi, Torki, Almehmadi, Yousef, Ali, Soad Shaker, Bharali, Dhruba J., Mousa, Shaker
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8912068/
https://www.ncbi.nlm.nih.gov/pubmed/35268707
http://dx.doi.org/10.3390/molecules27051605
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author Harakeh, Steve
Almuhayawi, Mohammed S.
Akefe, Isaac O.
Saber, Saber H.
Al Jaouni, Soad K.
Alzughaibi, Torki
Almehmadi, Yousef
Ali, Soad Shaker
Bharali, Dhruba J.
Mousa, Shaker
author_facet Harakeh, Steve
Almuhayawi, Mohammed S.
Akefe, Isaac O.
Saber, Saber H.
Al Jaouni, Soad K.
Alzughaibi, Torki
Almehmadi, Yousef
Ali, Soad Shaker
Bharali, Dhruba J.
Mousa, Shaker
author_sort Harakeh, Steve
collection PubMed
description Cisplatin (CISP) is one of the most widely used anti-cancer chemotherapeutic agents with remarkable efficacy against various types of cancers. However, it has been associated with nephrotoxicity amongst other undesirable side effects. Pomegranate (PE) is a potent antioxidant and anti-inflammatory agent effective against cancer, with a superior benefit of not being associated with the common toxicities related to the use of conventional chemotherapeutic agents. However, the application of PE is limited by its reduced solubility and decreased bioavailability. We investigated the potential of a novel nanoparticle (NP) enclosing PE to enhance its solubility and improve its bioavailability, and efficacy to prevent CISP-associated nephrotoxicity in a mice model of Ehrlich solid carcinoma (ESC). All mice were grouped into four cohorts: (I) control, (II) tumor, (III) CISP, and (IV) CISP + PE-NPs. The data obtained demonstrated that PE-NPs was beneficial in potently ameliorating CISP-induced nephrotoxicity in ESC mice. PE-NPs significantly attenuated CISP-induced oxidative stress and lipid peroxidation in the kidney via improving activities of antioxidants (SOD, GSH, and CAT). Additionally, PE-NPs considerably decreased CISP-induced inflammation in the kidney by decreasing the levels of NF-kB, IL-1β, and TNF-α. Notably, PE-NPs did not assuage the antitumor efficacy of CISP as revealed by histological assessment and tumor weight data. In summary, PE-NPs may be a potent alternative anticancer therapy devoid of nephrotoxicity.
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spelling pubmed-89120682022-03-11 Novel Pomegranate-Nanoparticles Ameliorate Cisplatin-Induced Nephrotoxicity and Improves Cisplatin Anti-Cancer Efficacy in Ehrlich Carcinoma Mice Model Harakeh, Steve Almuhayawi, Mohammed S. Akefe, Isaac O. Saber, Saber H. Al Jaouni, Soad K. Alzughaibi, Torki Almehmadi, Yousef Ali, Soad Shaker Bharali, Dhruba J. Mousa, Shaker Molecules Article Cisplatin (CISP) is one of the most widely used anti-cancer chemotherapeutic agents with remarkable efficacy against various types of cancers. However, it has been associated with nephrotoxicity amongst other undesirable side effects. Pomegranate (PE) is a potent antioxidant and anti-inflammatory agent effective against cancer, with a superior benefit of not being associated with the common toxicities related to the use of conventional chemotherapeutic agents. However, the application of PE is limited by its reduced solubility and decreased bioavailability. We investigated the potential of a novel nanoparticle (NP) enclosing PE to enhance its solubility and improve its bioavailability, and efficacy to prevent CISP-associated nephrotoxicity in a mice model of Ehrlich solid carcinoma (ESC). All mice were grouped into four cohorts: (I) control, (II) tumor, (III) CISP, and (IV) CISP + PE-NPs. The data obtained demonstrated that PE-NPs was beneficial in potently ameliorating CISP-induced nephrotoxicity in ESC mice. PE-NPs significantly attenuated CISP-induced oxidative stress and lipid peroxidation in the kidney via improving activities of antioxidants (SOD, GSH, and CAT). Additionally, PE-NPs considerably decreased CISP-induced inflammation in the kidney by decreasing the levels of NF-kB, IL-1β, and TNF-α. Notably, PE-NPs did not assuage the antitumor efficacy of CISP as revealed by histological assessment and tumor weight data. In summary, PE-NPs may be a potent alternative anticancer therapy devoid of nephrotoxicity. MDPI 2022-02-28 /pmc/articles/PMC8912068/ /pubmed/35268707 http://dx.doi.org/10.3390/molecules27051605 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Harakeh, Steve
Almuhayawi, Mohammed S.
Akefe, Isaac O.
Saber, Saber H.
Al Jaouni, Soad K.
Alzughaibi, Torki
Almehmadi, Yousef
Ali, Soad Shaker
Bharali, Dhruba J.
Mousa, Shaker
Novel Pomegranate-Nanoparticles Ameliorate Cisplatin-Induced Nephrotoxicity and Improves Cisplatin Anti-Cancer Efficacy in Ehrlich Carcinoma Mice Model
title Novel Pomegranate-Nanoparticles Ameliorate Cisplatin-Induced Nephrotoxicity and Improves Cisplatin Anti-Cancer Efficacy in Ehrlich Carcinoma Mice Model
title_full Novel Pomegranate-Nanoparticles Ameliorate Cisplatin-Induced Nephrotoxicity and Improves Cisplatin Anti-Cancer Efficacy in Ehrlich Carcinoma Mice Model
title_fullStr Novel Pomegranate-Nanoparticles Ameliorate Cisplatin-Induced Nephrotoxicity and Improves Cisplatin Anti-Cancer Efficacy in Ehrlich Carcinoma Mice Model
title_full_unstemmed Novel Pomegranate-Nanoparticles Ameliorate Cisplatin-Induced Nephrotoxicity and Improves Cisplatin Anti-Cancer Efficacy in Ehrlich Carcinoma Mice Model
title_short Novel Pomegranate-Nanoparticles Ameliorate Cisplatin-Induced Nephrotoxicity and Improves Cisplatin Anti-Cancer Efficacy in Ehrlich Carcinoma Mice Model
title_sort novel pomegranate-nanoparticles ameliorate cisplatin-induced nephrotoxicity and improves cisplatin anti-cancer efficacy in ehrlich carcinoma mice model
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8912068/
https://www.ncbi.nlm.nih.gov/pubmed/35268707
http://dx.doi.org/10.3390/molecules27051605
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