Rational Design and Synthesis of HSF1-PROTACs for Anticancer Drug Development

PROTACs employ the proteosome-mediated proteolysis via E3 ligase and recruit the natural protein degradation machinery to selectively degrade the cancerous proteins. Herein, we have designed and synthesized heterobifunctional small molecules that consist of different linkers tethering KRIBB11, a HSF...

Descripción completa

Detalles Bibliográficos
Autores principales: Sharma, Chiranjeev, Choi, Myeong A, Song, Yoojin, Seo, Young Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8912087/
https://www.ncbi.nlm.nih.gov/pubmed/35268755
http://dx.doi.org/10.3390/molecules27051655

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8912087/
https://www.ncbi.nlm.nih.gov/pubmed/35268755
http://dx.doi.org/10.3390/molecules27051655

Ejemplares similares