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Genome-wide association study reveals candidate genes relevant to body weight in female turkeys (Meleagris gallopavo)

The underlying genetic mechanisms affecting turkey growth traits have not been widely investigated. Genome-wide association studies (GWAS) is a powerful approach to identify candidate regions associated with complex phenotypes and diseases in livestock. In the present study, we performed GWAS to ide...

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Autores principales: Abdalla, Emhimad A. E., Makanjuola, Bayode O., Wood, Benjamin J., Baes, Christine F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8912253/
https://www.ncbi.nlm.nih.gov/pubmed/35271651
http://dx.doi.org/10.1371/journal.pone.0264838
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author Abdalla, Emhimad A. E.
Makanjuola, Bayode O.
Wood, Benjamin J.
Baes, Christine F.
author_facet Abdalla, Emhimad A. E.
Makanjuola, Bayode O.
Wood, Benjamin J.
Baes, Christine F.
author_sort Abdalla, Emhimad A. E.
collection PubMed
description The underlying genetic mechanisms affecting turkey growth traits have not been widely investigated. Genome-wide association studies (GWAS) is a powerful approach to identify candidate regions associated with complex phenotypes and diseases in livestock. In the present study, we performed GWAS to identify regions associated with 18-week body weight in a turkey population. The data included body weight observations for 24,989 female turkeys genotyped based on a 65K SNP panel. The analysis was carried out using a univariate mixed linear model with hatch-week-year and the 2 top principal components fitted as fixed effects and the accumulated polygenic effect of all markers captured by the genomic relationship matrix as random. Thirty-three significant markers were observed on 1, 2, 3, 4, 7 and 12 chromosomes, while 26 showed strong linkage disequilibrium extending up to 410 kb. These significant markers were mapped to 37 genes, of which 13 were novel. Interestingly, many of the investigated genes are known to be involved in growth and body weight. For instance, genes AKR1D1, PARP12, BOC, NCOA1, ADCY3 and CHCHD7 regulate growth, body weight, metabolism, digestion, bile acid biosynthetic and development of muscle cells. In summary, the results of our study revealed novel candidate genomic regions and candidate genes that could be managed within a turkey breeding program and adapted in fine mapping of quantitative trait loci to enhance genetic improvement in this species.
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spelling pubmed-89122532022-03-11 Genome-wide association study reveals candidate genes relevant to body weight in female turkeys (Meleagris gallopavo) Abdalla, Emhimad A. E. Makanjuola, Bayode O. Wood, Benjamin J. Baes, Christine F. PLoS One Research Article The underlying genetic mechanisms affecting turkey growth traits have not been widely investigated. Genome-wide association studies (GWAS) is a powerful approach to identify candidate regions associated with complex phenotypes and diseases in livestock. In the present study, we performed GWAS to identify regions associated with 18-week body weight in a turkey population. The data included body weight observations for 24,989 female turkeys genotyped based on a 65K SNP panel. The analysis was carried out using a univariate mixed linear model with hatch-week-year and the 2 top principal components fitted as fixed effects and the accumulated polygenic effect of all markers captured by the genomic relationship matrix as random. Thirty-three significant markers were observed on 1, 2, 3, 4, 7 and 12 chromosomes, while 26 showed strong linkage disequilibrium extending up to 410 kb. These significant markers were mapped to 37 genes, of which 13 were novel. Interestingly, many of the investigated genes are known to be involved in growth and body weight. For instance, genes AKR1D1, PARP12, BOC, NCOA1, ADCY3 and CHCHD7 regulate growth, body weight, metabolism, digestion, bile acid biosynthetic and development of muscle cells. In summary, the results of our study revealed novel candidate genomic regions and candidate genes that could be managed within a turkey breeding program and adapted in fine mapping of quantitative trait loci to enhance genetic improvement in this species. Public Library of Science 2022-03-10 /pmc/articles/PMC8912253/ /pubmed/35271651 http://dx.doi.org/10.1371/journal.pone.0264838 Text en © 2022 Abdalla et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Abdalla, Emhimad A. E.
Makanjuola, Bayode O.
Wood, Benjamin J.
Baes, Christine F.
Genome-wide association study reveals candidate genes relevant to body weight in female turkeys (Meleagris gallopavo)
title Genome-wide association study reveals candidate genes relevant to body weight in female turkeys (Meleagris gallopavo)
title_full Genome-wide association study reveals candidate genes relevant to body weight in female turkeys (Meleagris gallopavo)
title_fullStr Genome-wide association study reveals candidate genes relevant to body weight in female turkeys (Meleagris gallopavo)
title_full_unstemmed Genome-wide association study reveals candidate genes relevant to body weight in female turkeys (Meleagris gallopavo)
title_short Genome-wide association study reveals candidate genes relevant to body weight in female turkeys (Meleagris gallopavo)
title_sort genome-wide association study reveals candidate genes relevant to body weight in female turkeys (meleagris gallopavo)
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8912253/
https://www.ncbi.nlm.nih.gov/pubmed/35271651
http://dx.doi.org/10.1371/journal.pone.0264838
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