Poxviruses and paramyxoviruses use a conserved mechanism of STAT1 antagonism to inhibit interferon signaling

The induction of interferon (IFN)-stimulated genes by STATs is a critical host defense mechanism against virus infection. Here, we report that a highly expressed poxvirus protein, 018, inhibits IFN-induced signaling by binding to the SH2 domain of STAT1, thereby preventing the association of STAT1 w...

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Detalles Bibliográficos
Autores principales: Talbot-Cooper, Callum, Pantelejevs, Teodors, Shannon, John P., Cherry, Christian R., Au, Marcus T., Hyvönen, Marko, Hickman, Heather D., Smith, Geoffrey L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8912257/
https://www.ncbi.nlm.nih.gov/pubmed/35182467
http://dx.doi.org/10.1016/j.chom.2022.01.014

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