Cargando…

Advances in Modification Methods Based on Biodegradable Membranes in Guided Bone/Tissue Regeneration: A Review

Guided tissue/bone regeneration (GTR/GBR) is commonly applied in dentistry to aid in the regeneration of bone/tissue at a defective location, where the assistive material eventually degrades to be substituted with newly produced tissue. Membranes separate the rapidly propagating soft tissue from the...

Descripción completa

Detalles Bibliográficos
Autores principales: Gao, Yue, Wang, Shuai, Shi, Biying, Wang, Yuxuan, Chen, Yimeng, Wang, Xuanyi, Lee, Eui-Seok, Jiang, Heng-Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8912280/
https://www.ncbi.nlm.nih.gov/pubmed/35267700
http://dx.doi.org/10.3390/polym14050871
_version_ 1784667078399098880
author Gao, Yue
Wang, Shuai
Shi, Biying
Wang, Yuxuan
Chen, Yimeng
Wang, Xuanyi
Lee, Eui-Seok
Jiang, Heng-Bo
author_facet Gao, Yue
Wang, Shuai
Shi, Biying
Wang, Yuxuan
Chen, Yimeng
Wang, Xuanyi
Lee, Eui-Seok
Jiang, Heng-Bo
author_sort Gao, Yue
collection PubMed
description Guided tissue/bone regeneration (GTR/GBR) is commonly applied in dentistry to aid in the regeneration of bone/tissue at a defective location, where the assistive material eventually degrades to be substituted with newly produced tissue. Membranes separate the rapidly propagating soft tissue from the slow-growing bone tissue for optimal tissue regeneration results. A broad membrane exposure area, biocompatibility, hardness, ductility, cell occlusion, membrane void ratio, tissue integration, and clinical manageability are essential functional properties of a GTR/GBR membrane, although no single modern membrane conforms to all of the necessary characteristics. This review considers ongoing bone/tissue regeneration engineering research and the GTR/GBR materials described in this review fulfill all of the basic ISO requirements for human use, as determined through risk analysis and rigorous testing. Novel modified materials are in the early stages of development and could be classified as synthetic polymer membranes, biological extraction synthetic polymer membranes, or metal membranes. Cell attachment, proliferation, and subsequent tissue development are influenced by the physical features of GTR/GBR membrane materials, including pore size, porosity, and mechanical strength. According to the latest advances, key attributes of nanofillers introduced into a polymer matrix include suitable surface area, better mechanical capacity, and stability, which enhances cell adhesion, proliferation, and differentiation. Therefore, it is essential to construct a bionic membrane that satisfies the requirements for the mechanical barrier, the degradation rate, osteogenesis, and clinical operability.
format Online
Article
Text
id pubmed-8912280
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-89122802022-03-11 Advances in Modification Methods Based on Biodegradable Membranes in Guided Bone/Tissue Regeneration: A Review Gao, Yue Wang, Shuai Shi, Biying Wang, Yuxuan Chen, Yimeng Wang, Xuanyi Lee, Eui-Seok Jiang, Heng-Bo Polymers (Basel) Review Guided tissue/bone regeneration (GTR/GBR) is commonly applied in dentistry to aid in the regeneration of bone/tissue at a defective location, where the assistive material eventually degrades to be substituted with newly produced tissue. Membranes separate the rapidly propagating soft tissue from the slow-growing bone tissue for optimal tissue regeneration results. A broad membrane exposure area, biocompatibility, hardness, ductility, cell occlusion, membrane void ratio, tissue integration, and clinical manageability are essential functional properties of a GTR/GBR membrane, although no single modern membrane conforms to all of the necessary characteristics. This review considers ongoing bone/tissue regeneration engineering research and the GTR/GBR materials described in this review fulfill all of the basic ISO requirements for human use, as determined through risk analysis and rigorous testing. Novel modified materials are in the early stages of development and could be classified as synthetic polymer membranes, biological extraction synthetic polymer membranes, or metal membranes. Cell attachment, proliferation, and subsequent tissue development are influenced by the physical features of GTR/GBR membrane materials, including pore size, porosity, and mechanical strength. According to the latest advances, key attributes of nanofillers introduced into a polymer matrix include suitable surface area, better mechanical capacity, and stability, which enhances cell adhesion, proliferation, and differentiation. Therefore, it is essential to construct a bionic membrane that satisfies the requirements for the mechanical barrier, the degradation rate, osteogenesis, and clinical operability. MDPI 2022-02-23 /pmc/articles/PMC8912280/ /pubmed/35267700 http://dx.doi.org/10.3390/polym14050871 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Gao, Yue
Wang, Shuai
Shi, Biying
Wang, Yuxuan
Chen, Yimeng
Wang, Xuanyi
Lee, Eui-Seok
Jiang, Heng-Bo
Advances in Modification Methods Based on Biodegradable Membranes in Guided Bone/Tissue Regeneration: A Review
title Advances in Modification Methods Based on Biodegradable Membranes in Guided Bone/Tissue Regeneration: A Review
title_full Advances in Modification Methods Based on Biodegradable Membranes in Guided Bone/Tissue Regeneration: A Review
title_fullStr Advances in Modification Methods Based on Biodegradable Membranes in Guided Bone/Tissue Regeneration: A Review
title_full_unstemmed Advances in Modification Methods Based on Biodegradable Membranes in Guided Bone/Tissue Regeneration: A Review
title_short Advances in Modification Methods Based on Biodegradable Membranes in Guided Bone/Tissue Regeneration: A Review
title_sort advances in modification methods based on biodegradable membranes in guided bone/tissue regeneration: a review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8912280/
https://www.ncbi.nlm.nih.gov/pubmed/35267700
http://dx.doi.org/10.3390/polym14050871
work_keys_str_mv AT gaoyue advancesinmodificationmethodsbasedonbiodegradablemembranesinguidedbonetissueregenerationareview
AT wangshuai advancesinmodificationmethodsbasedonbiodegradablemembranesinguidedbonetissueregenerationareview
AT shibiying advancesinmodificationmethodsbasedonbiodegradablemembranesinguidedbonetissueregenerationareview
AT wangyuxuan advancesinmodificationmethodsbasedonbiodegradablemembranesinguidedbonetissueregenerationareview
AT chenyimeng advancesinmodificationmethodsbasedonbiodegradablemembranesinguidedbonetissueregenerationareview
AT wangxuanyi advancesinmodificationmethodsbasedonbiodegradablemembranesinguidedbonetissueregenerationareview
AT leeeuiseok advancesinmodificationmethodsbasedonbiodegradablemembranesinguidedbonetissueregenerationareview
AT jianghengbo advancesinmodificationmethodsbasedonbiodegradablemembranesinguidedbonetissueregenerationareview