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The Effect of Dietary Interventions on Hypertriglyceridemia: From Public Health to Molecular Nutrition Evidence

Approximately 25–50% of the population worldwide exhibits serum triglycerides (TG) (≥150 mg/dL) which are associated with an increased level of highly atherogenic remnant-like particles, non-alcoholic fatty liver disease, and pancreatitis risk. High serum TG levels could be related to cardiovascular...

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Autores principales: Luna-Castillo, Karla Paulina, Olivares-Ochoa, Xochitl Citlalli, Hernández-Ruiz, Rocío Guadalupe, Llamas-Covarrubias, Iris Monserrat, Rodríguez-Reyes, Saraí Citlalic, Betancourt-Núñez, Alejandra, Vizmanos, Barbara, Martínez-López, Erika, Muñoz-Valle, José Francisco, Márquez-Sandoval, Fabiola, López-Quintero, Andres
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8912493/
https://www.ncbi.nlm.nih.gov/pubmed/35268076
http://dx.doi.org/10.3390/nu14051104
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author Luna-Castillo, Karla Paulina
Olivares-Ochoa, Xochitl Citlalli
Hernández-Ruiz, Rocío Guadalupe
Llamas-Covarrubias, Iris Monserrat
Rodríguez-Reyes, Saraí Citlalic
Betancourt-Núñez, Alejandra
Vizmanos, Barbara
Martínez-López, Erika
Muñoz-Valle, José Francisco
Márquez-Sandoval, Fabiola
López-Quintero, Andres
author_facet Luna-Castillo, Karla Paulina
Olivares-Ochoa, Xochitl Citlalli
Hernández-Ruiz, Rocío Guadalupe
Llamas-Covarrubias, Iris Monserrat
Rodríguez-Reyes, Saraí Citlalic
Betancourt-Núñez, Alejandra
Vizmanos, Barbara
Martínez-López, Erika
Muñoz-Valle, José Francisco
Márquez-Sandoval, Fabiola
López-Quintero, Andres
author_sort Luna-Castillo, Karla Paulina
collection PubMed
description Approximately 25–50% of the population worldwide exhibits serum triglycerides (TG) (≥150 mg/dL) which are associated with an increased level of highly atherogenic remnant-like particles, non-alcoholic fatty liver disease, and pancreatitis risk. High serum TG levels could be related to cardiovascular disease, which is the most prevalent cause of mortality in Western countries. The etiology of hypertriglyceridemia (HTG) is multifactorial and can be classified as primary and secondary causes. Among the primary causes are genetic disorders. On the other hand, secondary causes of HTG comprise lifestyle factors, medical conditions, and drugs. Among lifestyle changes, adequate diets and nutrition are the initial steps to treat and prevent serum lipid alterations. Dietary intervention for HTG is recommended in order to modify the amount of macronutrients. Macronutrient distribution changes such as fat or protein, low-carbohydrate diets, and caloric restriction seem to be effective strategies in reducing TG levels. Particularly, the Mediterranean diet is the dietary pattern with the most consistent evidence for efficacy in HTG while the use of omega-3 supplements consumption is the dietary component with the highest number of randomized clinical trials (RCT) carried out with effective results on reducing TG. The aim of this review was to provide a better comprehension between human nutrition and lipid metabolism.
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spelling pubmed-89124932022-03-11 The Effect of Dietary Interventions on Hypertriglyceridemia: From Public Health to Molecular Nutrition Evidence Luna-Castillo, Karla Paulina Olivares-Ochoa, Xochitl Citlalli Hernández-Ruiz, Rocío Guadalupe Llamas-Covarrubias, Iris Monserrat Rodríguez-Reyes, Saraí Citlalic Betancourt-Núñez, Alejandra Vizmanos, Barbara Martínez-López, Erika Muñoz-Valle, José Francisco Márquez-Sandoval, Fabiola López-Quintero, Andres Nutrients Review Approximately 25–50% of the population worldwide exhibits serum triglycerides (TG) (≥150 mg/dL) which are associated with an increased level of highly atherogenic remnant-like particles, non-alcoholic fatty liver disease, and pancreatitis risk. High serum TG levels could be related to cardiovascular disease, which is the most prevalent cause of mortality in Western countries. The etiology of hypertriglyceridemia (HTG) is multifactorial and can be classified as primary and secondary causes. Among the primary causes are genetic disorders. On the other hand, secondary causes of HTG comprise lifestyle factors, medical conditions, and drugs. Among lifestyle changes, adequate diets and nutrition are the initial steps to treat and prevent serum lipid alterations. Dietary intervention for HTG is recommended in order to modify the amount of macronutrients. Macronutrient distribution changes such as fat or protein, low-carbohydrate diets, and caloric restriction seem to be effective strategies in reducing TG levels. Particularly, the Mediterranean diet is the dietary pattern with the most consistent evidence for efficacy in HTG while the use of omega-3 supplements consumption is the dietary component with the highest number of randomized clinical trials (RCT) carried out with effective results on reducing TG. The aim of this review was to provide a better comprehension between human nutrition and lipid metabolism. MDPI 2022-03-05 /pmc/articles/PMC8912493/ /pubmed/35268076 http://dx.doi.org/10.3390/nu14051104 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Luna-Castillo, Karla Paulina
Olivares-Ochoa, Xochitl Citlalli
Hernández-Ruiz, Rocío Guadalupe
Llamas-Covarrubias, Iris Monserrat
Rodríguez-Reyes, Saraí Citlalic
Betancourt-Núñez, Alejandra
Vizmanos, Barbara
Martínez-López, Erika
Muñoz-Valle, José Francisco
Márquez-Sandoval, Fabiola
López-Quintero, Andres
The Effect of Dietary Interventions on Hypertriglyceridemia: From Public Health to Molecular Nutrition Evidence
title The Effect of Dietary Interventions on Hypertriglyceridemia: From Public Health to Molecular Nutrition Evidence
title_full The Effect of Dietary Interventions on Hypertriglyceridemia: From Public Health to Molecular Nutrition Evidence
title_fullStr The Effect of Dietary Interventions on Hypertriglyceridemia: From Public Health to Molecular Nutrition Evidence
title_full_unstemmed The Effect of Dietary Interventions on Hypertriglyceridemia: From Public Health to Molecular Nutrition Evidence
title_short The Effect of Dietary Interventions on Hypertriglyceridemia: From Public Health to Molecular Nutrition Evidence
title_sort effect of dietary interventions on hypertriglyceridemia: from public health to molecular nutrition evidence
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8912493/
https://www.ncbi.nlm.nih.gov/pubmed/35268076
http://dx.doi.org/10.3390/nu14051104
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