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Is a Non-Caloric Sweetener-Free Diet Good to Treat Functional Gastrointestinal Disorder Symptoms? A Randomized Controlled Trial

Background: A diet containing non-caloric sweeteners (NCS) could reduce calorie intake; conversely, some animal studies suggest that NCS consumption may increase functional gastrointestinal disorder symptoms (FGDs). This study aimed to compare the effect of consuming a diet containing NCS (c-NCS) ve...

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Autores principales: Mendoza-Martínez, Viridiana Montsserrat, Zavala-Solares, Mónica Rocío, Espinosa-Flores, Aranza Jhosadara, León-Barrera, Karen Lorena, Alcántara-Suárez, Raúl, Carrillo-Ruíz, José Damián, Escobedo, Galileo, Roldan-Valadez, Ernesto, Esquivel-Velázquez, Marcela, Meléndez-Mier, Guillermo, Bueno-Hernández, Nallely
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8912523/
https://www.ncbi.nlm.nih.gov/pubmed/35268070
http://dx.doi.org/10.3390/nu14051095
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author Mendoza-Martínez, Viridiana Montsserrat
Zavala-Solares, Mónica Rocío
Espinosa-Flores, Aranza Jhosadara
León-Barrera, Karen Lorena
Alcántara-Suárez, Raúl
Carrillo-Ruíz, José Damián
Escobedo, Galileo
Roldan-Valadez, Ernesto
Esquivel-Velázquez, Marcela
Meléndez-Mier, Guillermo
Bueno-Hernández, Nallely
author_facet Mendoza-Martínez, Viridiana Montsserrat
Zavala-Solares, Mónica Rocío
Espinosa-Flores, Aranza Jhosadara
León-Barrera, Karen Lorena
Alcántara-Suárez, Raúl
Carrillo-Ruíz, José Damián
Escobedo, Galileo
Roldan-Valadez, Ernesto
Esquivel-Velázquez, Marcela
Meléndez-Mier, Guillermo
Bueno-Hernández, Nallely
author_sort Mendoza-Martínez, Viridiana Montsserrat
collection PubMed
description Background: A diet containing non-caloric sweeteners (NCS) could reduce calorie intake; conversely, some animal studies suggest that NCS consumption may increase functional gastrointestinal disorder symptoms (FGDs). This study aimed to compare the effect of consuming a diet containing NCS (c-NCS) versus a non-caloric sweetener-free diet (NCS-f) on FGDs. Methods: We conducted a randomized, controlled, parallel-group study using two different diets for five weeks: the c-NCS diet contained 50–100 mg/day NCS, whereas the NCS-f diet had less than 10 mg/day NCS. At the beginning of the study (PreTx) and at the end (PostTx), we assessed FGDs, dietary intake, and NCS consumption. Results: The percentage of participants with diarrhea (PreTx = 19% vs. PstTx = 56%; p = 0.02), post-prandial discomfort (PreTx = 9% vs. PstTx = 39%; p = 0.02), constipation (PreTx = 30% vs. PostTx = 56%; p < 0.01), and burning (PreTx = 13% vs. PostTx = 33%; p < 0.01) increased in the c-NCS diet group. Conversely, abdominal pain (PreTx = 15% vs. PostTx = 3%; p = 0.04), post-prandial discomfort (PreTx = 26% vs. PostTx = 6%; p = 0.02), burning (PreTx = 15% vs. PostTx = 0%; p = 0.02), early satiety (PreTx = 18% vs. PostTx = 3%; p < 0.01), and epigastric pain (PreTx = 38% vs. PostTx = 3%; p < 0.01) decreased in the NCS-f diet group. Conclusion: A c-NCS diet is associated with increased FGDs, including diarrhea, post-prandial discomfort, constipation, and burning or retrosternal pain. The NCS-f diet also decreased FGDs, as well as abdominal pain, post-prandial discomfort, burning or retrosternal pain, early satiety, and epigastric pain.
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spelling pubmed-89125232022-03-11 Is a Non-Caloric Sweetener-Free Diet Good to Treat Functional Gastrointestinal Disorder Symptoms? A Randomized Controlled Trial Mendoza-Martínez, Viridiana Montsserrat Zavala-Solares, Mónica Rocío Espinosa-Flores, Aranza Jhosadara León-Barrera, Karen Lorena Alcántara-Suárez, Raúl Carrillo-Ruíz, José Damián Escobedo, Galileo Roldan-Valadez, Ernesto Esquivel-Velázquez, Marcela Meléndez-Mier, Guillermo Bueno-Hernández, Nallely Nutrients Article Background: A diet containing non-caloric sweeteners (NCS) could reduce calorie intake; conversely, some animal studies suggest that NCS consumption may increase functional gastrointestinal disorder symptoms (FGDs). This study aimed to compare the effect of consuming a diet containing NCS (c-NCS) versus a non-caloric sweetener-free diet (NCS-f) on FGDs. Methods: We conducted a randomized, controlled, parallel-group study using two different diets for five weeks: the c-NCS diet contained 50–100 mg/day NCS, whereas the NCS-f diet had less than 10 mg/day NCS. At the beginning of the study (PreTx) and at the end (PostTx), we assessed FGDs, dietary intake, and NCS consumption. Results: The percentage of participants with diarrhea (PreTx = 19% vs. PstTx = 56%; p = 0.02), post-prandial discomfort (PreTx = 9% vs. PstTx = 39%; p = 0.02), constipation (PreTx = 30% vs. PostTx = 56%; p < 0.01), and burning (PreTx = 13% vs. PostTx = 33%; p < 0.01) increased in the c-NCS diet group. Conversely, abdominal pain (PreTx = 15% vs. PostTx = 3%; p = 0.04), post-prandial discomfort (PreTx = 26% vs. PostTx = 6%; p = 0.02), burning (PreTx = 15% vs. PostTx = 0%; p = 0.02), early satiety (PreTx = 18% vs. PostTx = 3%; p < 0.01), and epigastric pain (PreTx = 38% vs. PostTx = 3%; p < 0.01) decreased in the NCS-f diet group. Conclusion: A c-NCS diet is associated with increased FGDs, including diarrhea, post-prandial discomfort, constipation, and burning or retrosternal pain. The NCS-f diet also decreased FGDs, as well as abdominal pain, post-prandial discomfort, burning or retrosternal pain, early satiety, and epigastric pain. MDPI 2022-03-05 /pmc/articles/PMC8912523/ /pubmed/35268070 http://dx.doi.org/10.3390/nu14051095 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mendoza-Martínez, Viridiana Montsserrat
Zavala-Solares, Mónica Rocío
Espinosa-Flores, Aranza Jhosadara
León-Barrera, Karen Lorena
Alcántara-Suárez, Raúl
Carrillo-Ruíz, José Damián
Escobedo, Galileo
Roldan-Valadez, Ernesto
Esquivel-Velázquez, Marcela
Meléndez-Mier, Guillermo
Bueno-Hernández, Nallely
Is a Non-Caloric Sweetener-Free Diet Good to Treat Functional Gastrointestinal Disorder Symptoms? A Randomized Controlled Trial
title Is a Non-Caloric Sweetener-Free Diet Good to Treat Functional Gastrointestinal Disorder Symptoms? A Randomized Controlled Trial
title_full Is a Non-Caloric Sweetener-Free Diet Good to Treat Functional Gastrointestinal Disorder Symptoms? A Randomized Controlled Trial
title_fullStr Is a Non-Caloric Sweetener-Free Diet Good to Treat Functional Gastrointestinal Disorder Symptoms? A Randomized Controlled Trial
title_full_unstemmed Is a Non-Caloric Sweetener-Free Diet Good to Treat Functional Gastrointestinal Disorder Symptoms? A Randomized Controlled Trial
title_short Is a Non-Caloric Sweetener-Free Diet Good to Treat Functional Gastrointestinal Disorder Symptoms? A Randomized Controlled Trial
title_sort is a non-caloric sweetener-free diet good to treat functional gastrointestinal disorder symptoms? a randomized controlled trial
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8912523/
https://www.ncbi.nlm.nih.gov/pubmed/35268070
http://dx.doi.org/10.3390/nu14051095
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