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Assessing the Causal Effects of Adipokines on Uric Acid and Gout: A Two-Sample Mendelian Randomization Study

Previous observational studies have highlighted associations between adipokines and hyperuricemia, as well as gout, but the causality and direction of these associations are not clear. Therefore, we attempted to assess whether there are causal effects of specific adipokines (such as adiponectin (ADP...

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Autores principales: Cong, Ruyi, Zhang, Xiaoyu, Song, Zihong, Chen, Shanshan, Liu, Guanhua, Liu, Yizhi, Pang, Xiuyu, Dong, Fang, Xing, Weijia, Wang, Youxin, Xu, Xizhu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8912555/
https://www.ncbi.nlm.nih.gov/pubmed/35268067
http://dx.doi.org/10.3390/nu14051091
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author Cong, Ruyi
Zhang, Xiaoyu
Song, Zihong
Chen, Shanshan
Liu, Guanhua
Liu, Yizhi
Pang, Xiuyu
Dong, Fang
Xing, Weijia
Wang, Youxin
Xu, Xizhu
author_facet Cong, Ruyi
Zhang, Xiaoyu
Song, Zihong
Chen, Shanshan
Liu, Guanhua
Liu, Yizhi
Pang, Xiuyu
Dong, Fang
Xing, Weijia
Wang, Youxin
Xu, Xizhu
author_sort Cong, Ruyi
collection PubMed
description Previous observational studies have highlighted associations between adipokines and hyperuricemia, as well as gout, but the causality and direction of these associations are not clear. Therefore, we attempted to assess whether there are causal effects of specific adipokines (such as adiponectin (ADP) and soluble leptin receptors (sOB-R)) on uric acid (UA) or gout in a two-sample Mendelian randomization (MR) analysis, based on summary statistics from large genome-wide association studies. The inverse-variance weighted (IVW) method was performed as the primary analysis. Sensitivity analyses (including MR-Egger regression, weighted median, penalized weighted median, and MR pleiotropy residual sum and outlier methods) were also performed, to ensure reliable results. In the IVW models, no causal effect was found for sOB-R (odds ratios (OR), 1.002; 95% confidence intervals (CI), 0.999–1.004; p = 0.274) on UA, or ADP (OR, 1.198; 95% CI, 0.865–1.659; p = 0.277) or sOB-R (OR, 0.988; 95% CI, 0.940–1.037; p = 0.616) on gout. The results were confirmed in sensitivity analyses. There was no notable directional pleiotropy or heterogeneity. This study suggests that these specific adipokines may not play causal roles in UA or gout development.
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spelling pubmed-89125552022-03-11 Assessing the Causal Effects of Adipokines on Uric Acid and Gout: A Two-Sample Mendelian Randomization Study Cong, Ruyi Zhang, Xiaoyu Song, Zihong Chen, Shanshan Liu, Guanhua Liu, Yizhi Pang, Xiuyu Dong, Fang Xing, Weijia Wang, Youxin Xu, Xizhu Nutrients Article Previous observational studies have highlighted associations between adipokines and hyperuricemia, as well as gout, but the causality and direction of these associations are not clear. Therefore, we attempted to assess whether there are causal effects of specific adipokines (such as adiponectin (ADP) and soluble leptin receptors (sOB-R)) on uric acid (UA) or gout in a two-sample Mendelian randomization (MR) analysis, based on summary statistics from large genome-wide association studies. The inverse-variance weighted (IVW) method was performed as the primary analysis. Sensitivity analyses (including MR-Egger regression, weighted median, penalized weighted median, and MR pleiotropy residual sum and outlier methods) were also performed, to ensure reliable results. In the IVW models, no causal effect was found for sOB-R (odds ratios (OR), 1.002; 95% confidence intervals (CI), 0.999–1.004; p = 0.274) on UA, or ADP (OR, 1.198; 95% CI, 0.865–1.659; p = 0.277) or sOB-R (OR, 0.988; 95% CI, 0.940–1.037; p = 0.616) on gout. The results were confirmed in sensitivity analyses. There was no notable directional pleiotropy or heterogeneity. This study suggests that these specific adipokines may not play causal roles in UA or gout development. MDPI 2022-03-05 /pmc/articles/PMC8912555/ /pubmed/35268067 http://dx.doi.org/10.3390/nu14051091 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cong, Ruyi
Zhang, Xiaoyu
Song, Zihong
Chen, Shanshan
Liu, Guanhua
Liu, Yizhi
Pang, Xiuyu
Dong, Fang
Xing, Weijia
Wang, Youxin
Xu, Xizhu
Assessing the Causal Effects of Adipokines on Uric Acid and Gout: A Two-Sample Mendelian Randomization Study
title Assessing the Causal Effects of Adipokines on Uric Acid and Gout: A Two-Sample Mendelian Randomization Study
title_full Assessing the Causal Effects of Adipokines on Uric Acid and Gout: A Two-Sample Mendelian Randomization Study
title_fullStr Assessing the Causal Effects of Adipokines on Uric Acid and Gout: A Two-Sample Mendelian Randomization Study
title_full_unstemmed Assessing the Causal Effects of Adipokines on Uric Acid and Gout: A Two-Sample Mendelian Randomization Study
title_short Assessing the Causal Effects of Adipokines on Uric Acid and Gout: A Two-Sample Mendelian Randomization Study
title_sort assessing the causal effects of adipokines on uric acid and gout: a two-sample mendelian randomization study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8912555/
https://www.ncbi.nlm.nih.gov/pubmed/35268067
http://dx.doi.org/10.3390/nu14051091
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