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Development and Validation of Cutoff Value for Reduced Muscle Mass for GLIM Criteria in Patients with Gastrointestinal and Hepatobiliary–Pancreatic Cancers
The Global Leadership Initiative on Malnutrition (GLIM) criteria recommends using race- and sex-adjusted cutoff values for reduced muscle mass (RMM), but the only cutoff values available for Asians are the skeletal muscle mass index (SMI) established by the Asian Working Group for Sarcopenia (AWGS)....
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8912591/ https://www.ncbi.nlm.nih.gov/pubmed/35267918 http://dx.doi.org/10.3390/nu14050943 |
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author | Takimoto, Mami Yasui-Yamada, Sonoko Nasu, Nanami Kagiya, Natsumi Aotani, Nozomi Kurokawa, Yumiko Tani-Suzuki, Yoshiko Kashihara, Hideya Saito, Yu Nishi, Masaaki Shimada, Mitsuo Hamada, Yasuhiro |
author_facet | Takimoto, Mami Yasui-Yamada, Sonoko Nasu, Nanami Kagiya, Natsumi Aotani, Nozomi Kurokawa, Yumiko Tani-Suzuki, Yoshiko Kashihara, Hideya Saito, Yu Nishi, Masaaki Shimada, Mitsuo Hamada, Yasuhiro |
author_sort | Takimoto, Mami |
collection | PubMed |
description | The Global Leadership Initiative on Malnutrition (GLIM) criteria recommends using race- and sex-adjusted cutoff values for reduced muscle mass (RMM), but the only cutoff values available for Asians are the skeletal muscle mass index (SMI) established by the Asian Working Group for Sarcopenia (AWGS). This retrospective study aimed to develop and validate cutoff values for the fat-free mass index (FFMI) and arm circumference (AC) of Asians, and to investigate the association between GLIM malnutrition and prognosis. A total of 660 patients with primary gastrointestinal (GI) and hepatobiliary–pancreatic (HBP) cancers who underwent their first resection surgery were recruited and randomly divided into development and validation groups. The FFMI and AC cutoff values were calculated by receiver operating characteristic curve analysis for the AWGS SMI as the gold standard. The cutoff values for each RMM were used to diagnose malnutrition on the basis of GLIM criteria, and the survival rates were compared. The optimal FFMI cutoff values for RMM were 17 kg/m(2) for men and 15 kg/m(2) for women, and for AC were 27 cm for men and 25 cm for women. In the validation group, the accuracy of the FFMI and AC cutoff values to discriminate RMM were 85.2% and 68.8%, respectively. Using any of the three measures of RMM, overall survival rates were significantly lower in the GLIM malnutrition group. In conclusion, the cutoff values for the FFMI and AC in this study could discriminate RMM, and GLIM malnutrition using these cutoff values was associated with decreased survival. |
format | Online Article Text |
id | pubmed-8912591 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-89125912022-03-11 Development and Validation of Cutoff Value for Reduced Muscle Mass for GLIM Criteria in Patients with Gastrointestinal and Hepatobiliary–Pancreatic Cancers Takimoto, Mami Yasui-Yamada, Sonoko Nasu, Nanami Kagiya, Natsumi Aotani, Nozomi Kurokawa, Yumiko Tani-Suzuki, Yoshiko Kashihara, Hideya Saito, Yu Nishi, Masaaki Shimada, Mitsuo Hamada, Yasuhiro Nutrients Article The Global Leadership Initiative on Malnutrition (GLIM) criteria recommends using race- and sex-adjusted cutoff values for reduced muscle mass (RMM), but the only cutoff values available for Asians are the skeletal muscle mass index (SMI) established by the Asian Working Group for Sarcopenia (AWGS). This retrospective study aimed to develop and validate cutoff values for the fat-free mass index (FFMI) and arm circumference (AC) of Asians, and to investigate the association between GLIM malnutrition and prognosis. A total of 660 patients with primary gastrointestinal (GI) and hepatobiliary–pancreatic (HBP) cancers who underwent their first resection surgery were recruited and randomly divided into development and validation groups. The FFMI and AC cutoff values were calculated by receiver operating characteristic curve analysis for the AWGS SMI as the gold standard. The cutoff values for each RMM were used to diagnose malnutrition on the basis of GLIM criteria, and the survival rates were compared. The optimal FFMI cutoff values for RMM were 17 kg/m(2) for men and 15 kg/m(2) for women, and for AC were 27 cm for men and 25 cm for women. In the validation group, the accuracy of the FFMI and AC cutoff values to discriminate RMM were 85.2% and 68.8%, respectively. Using any of the three measures of RMM, overall survival rates were significantly lower in the GLIM malnutrition group. In conclusion, the cutoff values for the FFMI and AC in this study could discriminate RMM, and GLIM malnutrition using these cutoff values was associated with decreased survival. MDPI 2022-02-23 /pmc/articles/PMC8912591/ /pubmed/35267918 http://dx.doi.org/10.3390/nu14050943 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Takimoto, Mami Yasui-Yamada, Sonoko Nasu, Nanami Kagiya, Natsumi Aotani, Nozomi Kurokawa, Yumiko Tani-Suzuki, Yoshiko Kashihara, Hideya Saito, Yu Nishi, Masaaki Shimada, Mitsuo Hamada, Yasuhiro Development and Validation of Cutoff Value for Reduced Muscle Mass for GLIM Criteria in Patients with Gastrointestinal and Hepatobiliary–Pancreatic Cancers |
title | Development and Validation of Cutoff Value for Reduced Muscle Mass for GLIM Criteria in Patients with Gastrointestinal and Hepatobiliary–Pancreatic Cancers |
title_full | Development and Validation of Cutoff Value for Reduced Muscle Mass for GLIM Criteria in Patients with Gastrointestinal and Hepatobiliary–Pancreatic Cancers |
title_fullStr | Development and Validation of Cutoff Value for Reduced Muscle Mass for GLIM Criteria in Patients with Gastrointestinal and Hepatobiliary–Pancreatic Cancers |
title_full_unstemmed | Development and Validation of Cutoff Value for Reduced Muscle Mass for GLIM Criteria in Patients with Gastrointestinal and Hepatobiliary–Pancreatic Cancers |
title_short | Development and Validation of Cutoff Value for Reduced Muscle Mass for GLIM Criteria in Patients with Gastrointestinal and Hepatobiliary–Pancreatic Cancers |
title_sort | development and validation of cutoff value for reduced muscle mass for glim criteria in patients with gastrointestinal and hepatobiliary–pancreatic cancers |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8912591/ https://www.ncbi.nlm.nih.gov/pubmed/35267918 http://dx.doi.org/10.3390/nu14050943 |
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