Thermosensitive Polymers and Thermo-Responsive Liposomal Drug Delivery Systems

Temperature excursions within a biological milieu can be effectively used to induce drug release from thermosensitive drug-encapsulating nanoparticles. Oncological hyperthermia is of particular interest, as it is proven to synergistically act to arrest tumor growth when combined with optimally-desig...

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Autores principales: Abuwatfa, Waad H., Awad, Nahid S., Pitt, William G., Husseini, Ghaleb A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8912701/
https://www.ncbi.nlm.nih.gov/pubmed/35267747
http://dx.doi.org/10.3390/polym14050925
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author Abuwatfa, Waad H.
Awad, Nahid S.
Pitt, William G.
Husseini, Ghaleb A.
author_facet Abuwatfa, Waad H.
Awad, Nahid S.
Pitt, William G.
Husseini, Ghaleb A.
author_sort Abuwatfa, Waad H.
collection PubMed
description Temperature excursions within a biological milieu can be effectively used to induce drug release from thermosensitive drug-encapsulating nanoparticles. Oncological hyperthermia is of particular interest, as it is proven to synergistically act to arrest tumor growth when combined with optimally-designed smart drug delivery systems (DDSs). Thermoresponsive DDSs aid in making the drugs more bioavailable, enhance the therapeutic index and pharmacokinetic trends, and provide the spatial placement and temporal delivery of the drug into localized anatomical sites. This paper reviews the fundamentals of thermosensitive polymers, with a particular focus on thermoresponsive liposomal-based drug delivery systems.
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spelling pubmed-89127012022-03-11 Thermosensitive Polymers and Thermo-Responsive Liposomal Drug Delivery Systems Abuwatfa, Waad H. Awad, Nahid S. Pitt, William G. Husseini, Ghaleb A. Polymers (Basel) Review Temperature excursions within a biological milieu can be effectively used to induce drug release from thermosensitive drug-encapsulating nanoparticles. Oncological hyperthermia is of particular interest, as it is proven to synergistically act to arrest tumor growth when combined with optimally-designed smart drug delivery systems (DDSs). Thermoresponsive DDSs aid in making the drugs more bioavailable, enhance the therapeutic index and pharmacokinetic trends, and provide the spatial placement and temporal delivery of the drug into localized anatomical sites. This paper reviews the fundamentals of thermosensitive polymers, with a particular focus on thermoresponsive liposomal-based drug delivery systems. MDPI 2022-02-25 /pmc/articles/PMC8912701/ /pubmed/35267747 http://dx.doi.org/10.3390/polym14050925 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Abuwatfa, Waad H.
Awad, Nahid S.
Pitt, William G.
Husseini, Ghaleb A.
Thermosensitive Polymers and Thermo-Responsive Liposomal Drug Delivery Systems
title Thermosensitive Polymers and Thermo-Responsive Liposomal Drug Delivery Systems
title_full Thermosensitive Polymers and Thermo-Responsive Liposomal Drug Delivery Systems
title_fullStr Thermosensitive Polymers and Thermo-Responsive Liposomal Drug Delivery Systems
title_full_unstemmed Thermosensitive Polymers and Thermo-Responsive Liposomal Drug Delivery Systems
title_short Thermosensitive Polymers and Thermo-Responsive Liposomal Drug Delivery Systems
title_sort thermosensitive polymers and thermo-responsive liposomal drug delivery systems
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8912701/
https://www.ncbi.nlm.nih.gov/pubmed/35267747
http://dx.doi.org/10.3390/polym14050925
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