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In Vivo Biocompatibility of an Innovative Elastomer for Heart Assist Devices

Cardiac surgical approaches require the development of new materials regardless of the polyurethanes used for pulsatile blood pumps; therefore, an innovative biomaterial, a copolymer of poly(ethylene terephthalate) and dimer fatty acid (dilinoleic acid) modified with D-glucitol, hereafter referred t...

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Autores principales: Zawidlak-Węgrzyńska, Barbara, Fray, Miroslawa El, Janiczak, Karolina, Kustosz, Roman, Gonsior, Małgorzata, Grabarek, Beniamin Oskar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8912705/
https://www.ncbi.nlm.nih.gov/pubmed/35267825
http://dx.doi.org/10.3390/polym14051002
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author Zawidlak-Węgrzyńska, Barbara
Fray, Miroslawa El
Janiczak, Karolina
Kustosz, Roman
Gonsior, Małgorzata
Grabarek, Beniamin Oskar
author_facet Zawidlak-Węgrzyńska, Barbara
Fray, Miroslawa El
Janiczak, Karolina
Kustosz, Roman
Gonsior, Małgorzata
Grabarek, Beniamin Oskar
author_sort Zawidlak-Węgrzyńska, Barbara
collection PubMed
description Cardiac surgical approaches require the development of new materials regardless of the polyurethanes used for pulsatile blood pumps; therefore, an innovative biomaterial, a copolymer of poly(ethylene terephthalate) and dimer fatty acid (dilinoleic acid) modified with D-glucitol, hereafter referred to as PET/DLA, has been developed, showing non-hemolytic and atrombogenic properties and resistance to biodegradation. The aim of this work was to evaluate in vivo inflammatory responses to intramuscular implantation of PET/DLA biomaterials of different compositions (hard to soft segments). Two copolymers containing 70 and 65 wt.% of hard segments, as in poly(ethylene terephthalate) and dilinoleic acid in soft segments modified with D-glucitol, were used for implantation tests to monitor tissue response. Medical grade polyurethanes Bionate II 90A and Bionate II 55 were used as reference materials. After euthanasia of animals (New Zealand White rabbits, n = 49), internal organs and tissues that contacted the material were collected for histopathological examination. The following parameters were determined: peripheral blood count, blood smear with May Grunwald–Giemsa staining, and serum C-reactive protein (CRPP). The healing process observed at the implantation site of the new materials after 12 weeks indicated normal progressive collagenization of the scar, with an indication of the inflammatory–resorptive process. The analysis of the chemical structure of explants 12 weeks after implantation showed good stability of the tested copolymers in contact with living tissues. Overall, the obtained results indicate great potential for PET/DLA in medical applications; however, final verification of its applicability as a structural material in prostheses is needed.
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spelling pubmed-89127052022-03-11 In Vivo Biocompatibility of an Innovative Elastomer for Heart Assist Devices Zawidlak-Węgrzyńska, Barbara Fray, Miroslawa El Janiczak, Karolina Kustosz, Roman Gonsior, Małgorzata Grabarek, Beniamin Oskar Polymers (Basel) Article Cardiac surgical approaches require the development of new materials regardless of the polyurethanes used for pulsatile blood pumps; therefore, an innovative biomaterial, a copolymer of poly(ethylene terephthalate) and dimer fatty acid (dilinoleic acid) modified with D-glucitol, hereafter referred to as PET/DLA, has been developed, showing non-hemolytic and atrombogenic properties and resistance to biodegradation. The aim of this work was to evaluate in vivo inflammatory responses to intramuscular implantation of PET/DLA biomaterials of different compositions (hard to soft segments). Two copolymers containing 70 and 65 wt.% of hard segments, as in poly(ethylene terephthalate) and dilinoleic acid in soft segments modified with D-glucitol, were used for implantation tests to monitor tissue response. Medical grade polyurethanes Bionate II 90A and Bionate II 55 were used as reference materials. After euthanasia of animals (New Zealand White rabbits, n = 49), internal organs and tissues that contacted the material were collected for histopathological examination. The following parameters were determined: peripheral blood count, blood smear with May Grunwald–Giemsa staining, and serum C-reactive protein (CRPP). The healing process observed at the implantation site of the new materials after 12 weeks indicated normal progressive collagenization of the scar, with an indication of the inflammatory–resorptive process. The analysis of the chemical structure of explants 12 weeks after implantation showed good stability of the tested copolymers in contact with living tissues. Overall, the obtained results indicate great potential for PET/DLA in medical applications; however, final verification of its applicability as a structural material in prostheses is needed. MDPI 2022-03-02 /pmc/articles/PMC8912705/ /pubmed/35267825 http://dx.doi.org/10.3390/polym14051002 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zawidlak-Węgrzyńska, Barbara
Fray, Miroslawa El
Janiczak, Karolina
Kustosz, Roman
Gonsior, Małgorzata
Grabarek, Beniamin Oskar
In Vivo Biocompatibility of an Innovative Elastomer for Heart Assist Devices
title In Vivo Biocompatibility of an Innovative Elastomer for Heart Assist Devices
title_full In Vivo Biocompatibility of an Innovative Elastomer for Heart Assist Devices
title_fullStr In Vivo Biocompatibility of an Innovative Elastomer for Heart Assist Devices
title_full_unstemmed In Vivo Biocompatibility of an Innovative Elastomer for Heart Assist Devices
title_short In Vivo Biocompatibility of an Innovative Elastomer for Heart Assist Devices
title_sort in vivo biocompatibility of an innovative elastomer for heart assist devices
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8912705/
https://www.ncbi.nlm.nih.gov/pubmed/35267825
http://dx.doi.org/10.3390/polym14051002
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