Cargando…
Polyethyleneimine-Functionalized Carbon Nanotubes Enabling Potent Antimycotic Activity of Lyticase
In this work, the positively-charged polymer polyethyleneimine was used to functionalize carbon nanotubes and activated carbon to load antimycotic enzyme lyticase. Interestingly, polyethyleneimine played a dual role functionalizing carbon materials to synergistically enhance antimycotic activity of...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8912707/ https://www.ncbi.nlm.nih.gov/pubmed/35267782 http://dx.doi.org/10.3390/polym14050959 |
_version_ | 1784667216039378944 |
---|---|
author | Liang, Weibing Chen, Ming Li, Lin Yan, Liqiang Wang, Xiuli Wu, Xiongzhi Lei, Chenghong |
author_facet | Liang, Weibing Chen, Ming Li, Lin Yan, Liqiang Wang, Xiuli Wu, Xiongzhi Lei, Chenghong |
author_sort | Liang, Weibing |
collection | PubMed |
description | In this work, the positively-charged polymer polyethyleneimine was used to functionalize carbon nanotubes and activated carbon to load antimycotic enzyme lyticase. Interestingly, polyethyleneimine played a dual role functionalizing carbon materials to synergistically enhance antimycotic activity of loaded lyticase as well as exhibiting its own apparent antimycotic activity, where the enhanced enzymatic activity of loaded lyticase on functionalized carbon nanotubes was more than 2.8 times as high as the activity of free enzyme in solution. The actual activity of loaded lyticase on functionalized carbon nanotubes was applied with Penicillium janthinellum, exhibiting much faster digesting lysis of the bacteria in comparison with free lyticase. The synergistic and potent antimycotic activities from combined action of antimycotic lyticase and polyethyleneimine on carbon nanotubes provides a new antimycotic protection for medicine, food industry, and other biochemical processes. |
format | Online Article Text |
id | pubmed-8912707 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-89127072022-03-11 Polyethyleneimine-Functionalized Carbon Nanotubes Enabling Potent Antimycotic Activity of Lyticase Liang, Weibing Chen, Ming Li, Lin Yan, Liqiang Wang, Xiuli Wu, Xiongzhi Lei, Chenghong Polymers (Basel) Communication In this work, the positively-charged polymer polyethyleneimine was used to functionalize carbon nanotubes and activated carbon to load antimycotic enzyme lyticase. Interestingly, polyethyleneimine played a dual role functionalizing carbon materials to synergistically enhance antimycotic activity of loaded lyticase as well as exhibiting its own apparent antimycotic activity, where the enhanced enzymatic activity of loaded lyticase on functionalized carbon nanotubes was more than 2.8 times as high as the activity of free enzyme in solution. The actual activity of loaded lyticase on functionalized carbon nanotubes was applied with Penicillium janthinellum, exhibiting much faster digesting lysis of the bacteria in comparison with free lyticase. The synergistic and potent antimycotic activities from combined action of antimycotic lyticase and polyethyleneimine on carbon nanotubes provides a new antimycotic protection for medicine, food industry, and other biochemical processes. MDPI 2022-02-28 /pmc/articles/PMC8912707/ /pubmed/35267782 http://dx.doi.org/10.3390/polym14050959 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Communication Liang, Weibing Chen, Ming Li, Lin Yan, Liqiang Wang, Xiuli Wu, Xiongzhi Lei, Chenghong Polyethyleneimine-Functionalized Carbon Nanotubes Enabling Potent Antimycotic Activity of Lyticase |
title | Polyethyleneimine-Functionalized Carbon Nanotubes Enabling Potent Antimycotic Activity of Lyticase |
title_full | Polyethyleneimine-Functionalized Carbon Nanotubes Enabling Potent Antimycotic Activity of Lyticase |
title_fullStr | Polyethyleneimine-Functionalized Carbon Nanotubes Enabling Potent Antimycotic Activity of Lyticase |
title_full_unstemmed | Polyethyleneimine-Functionalized Carbon Nanotubes Enabling Potent Antimycotic Activity of Lyticase |
title_short | Polyethyleneimine-Functionalized Carbon Nanotubes Enabling Potent Antimycotic Activity of Lyticase |
title_sort | polyethyleneimine-functionalized carbon nanotubes enabling potent antimycotic activity of lyticase |
topic | Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8912707/ https://www.ncbi.nlm.nih.gov/pubmed/35267782 http://dx.doi.org/10.3390/polym14050959 |
work_keys_str_mv | AT liangweibing polyethyleneiminefunctionalizedcarbonnanotubesenablingpotentantimycoticactivityoflyticase AT chenming polyethyleneiminefunctionalizedcarbonnanotubesenablingpotentantimycoticactivityoflyticase AT lilin polyethyleneiminefunctionalizedcarbonnanotubesenablingpotentantimycoticactivityoflyticase AT yanliqiang polyethyleneiminefunctionalizedcarbonnanotubesenablingpotentantimycoticactivityoflyticase AT wangxiuli polyethyleneiminefunctionalizedcarbonnanotubesenablingpotentantimycoticactivityoflyticase AT wuxiongzhi polyethyleneiminefunctionalizedcarbonnanotubesenablingpotentantimycoticactivityoflyticase AT leichenghong polyethyleneiminefunctionalizedcarbonnanotubesenablingpotentantimycoticactivityoflyticase |