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Polyethyleneimine-Functionalized Carbon Nanotubes Enabling Potent Antimycotic Activity of Lyticase

In this work, the positively-charged polymer polyethyleneimine was used to functionalize carbon nanotubes and activated carbon to load antimycotic enzyme lyticase. Interestingly, polyethyleneimine played a dual role functionalizing carbon materials to synergistically enhance antimycotic activity of...

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Detalles Bibliográficos
Autores principales: Liang, Weibing, Chen, Ming, Li, Lin, Yan, Liqiang, Wang, Xiuli, Wu, Xiongzhi, Lei, Chenghong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8912707/
https://www.ncbi.nlm.nih.gov/pubmed/35267782
http://dx.doi.org/10.3390/polym14050959
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author Liang, Weibing
Chen, Ming
Li, Lin
Yan, Liqiang
Wang, Xiuli
Wu, Xiongzhi
Lei, Chenghong
author_facet Liang, Weibing
Chen, Ming
Li, Lin
Yan, Liqiang
Wang, Xiuli
Wu, Xiongzhi
Lei, Chenghong
author_sort Liang, Weibing
collection PubMed
description In this work, the positively-charged polymer polyethyleneimine was used to functionalize carbon nanotubes and activated carbon to load antimycotic enzyme lyticase. Interestingly, polyethyleneimine played a dual role functionalizing carbon materials to synergistically enhance antimycotic activity of loaded lyticase as well as exhibiting its own apparent antimycotic activity, where the enhanced enzymatic activity of loaded lyticase on functionalized carbon nanotubes was more than 2.8 times as high as the activity of free enzyme in solution. The actual activity of loaded lyticase on functionalized carbon nanotubes was applied with Penicillium janthinellum, exhibiting much faster digesting lysis of the bacteria in comparison with free lyticase. The synergistic and potent antimycotic activities from combined action of antimycotic lyticase and polyethyleneimine on carbon nanotubes provides a new antimycotic protection for medicine, food industry, and other biochemical processes.
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spelling pubmed-89127072022-03-11 Polyethyleneimine-Functionalized Carbon Nanotubes Enabling Potent Antimycotic Activity of Lyticase Liang, Weibing Chen, Ming Li, Lin Yan, Liqiang Wang, Xiuli Wu, Xiongzhi Lei, Chenghong Polymers (Basel) Communication In this work, the positively-charged polymer polyethyleneimine was used to functionalize carbon nanotubes and activated carbon to load antimycotic enzyme lyticase. Interestingly, polyethyleneimine played a dual role functionalizing carbon materials to synergistically enhance antimycotic activity of loaded lyticase as well as exhibiting its own apparent antimycotic activity, where the enhanced enzymatic activity of loaded lyticase on functionalized carbon nanotubes was more than 2.8 times as high as the activity of free enzyme in solution. The actual activity of loaded lyticase on functionalized carbon nanotubes was applied with Penicillium janthinellum, exhibiting much faster digesting lysis of the bacteria in comparison with free lyticase. The synergistic and potent antimycotic activities from combined action of antimycotic lyticase and polyethyleneimine on carbon nanotubes provides a new antimycotic protection for medicine, food industry, and other biochemical processes. MDPI 2022-02-28 /pmc/articles/PMC8912707/ /pubmed/35267782 http://dx.doi.org/10.3390/polym14050959 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Liang, Weibing
Chen, Ming
Li, Lin
Yan, Liqiang
Wang, Xiuli
Wu, Xiongzhi
Lei, Chenghong
Polyethyleneimine-Functionalized Carbon Nanotubes Enabling Potent Antimycotic Activity of Lyticase
title Polyethyleneimine-Functionalized Carbon Nanotubes Enabling Potent Antimycotic Activity of Lyticase
title_full Polyethyleneimine-Functionalized Carbon Nanotubes Enabling Potent Antimycotic Activity of Lyticase
title_fullStr Polyethyleneimine-Functionalized Carbon Nanotubes Enabling Potent Antimycotic Activity of Lyticase
title_full_unstemmed Polyethyleneimine-Functionalized Carbon Nanotubes Enabling Potent Antimycotic Activity of Lyticase
title_short Polyethyleneimine-Functionalized Carbon Nanotubes Enabling Potent Antimycotic Activity of Lyticase
title_sort polyethyleneimine-functionalized carbon nanotubes enabling potent antimycotic activity of lyticase
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8912707/
https://www.ncbi.nlm.nih.gov/pubmed/35267782
http://dx.doi.org/10.3390/polym14050959
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