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The Intestinal Barrier Dysfunction as Driving Factor of Inflammaging
The intestinal barrier, composed of the luminal microbiota, the mucus layer, and the physical barrier consisting of epithelial cells and immune cells, the latter residing underneath and within the epithelial cells, plays a special role in health and disease. While there is growing knowledge on the c...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8912763/ https://www.ncbi.nlm.nih.gov/pubmed/35267924 http://dx.doi.org/10.3390/nu14050949 |
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author | Untersmayr, Eva Brandt, Annette Koidl, Larissa Bergheim, Ina |
author_facet | Untersmayr, Eva Brandt, Annette Koidl, Larissa Bergheim, Ina |
author_sort | Untersmayr, Eva |
collection | PubMed |
description | The intestinal barrier, composed of the luminal microbiota, the mucus layer, and the physical barrier consisting of epithelial cells and immune cells, the latter residing underneath and within the epithelial cells, plays a special role in health and disease. While there is growing knowledge on the changes to the different layers associated with disease development, the barrier function also plays an important role during aging. Besides changes in the composition and function of cellular junctions, the entire gastrointestinal physiology contributes to essential age-related changes. This is also reflected by substantial differences in the microbial composition throughout the life span. Even though it remains difficult to define physiological age-related changes and to distinguish them from early signs of pathologies, studies in centenarians provide insights into the intestinal barrier features associated with longevity. The knowledge reviewed in this narrative review article might contribute to the definition of strategies to prevent the development of diseases in the elderly. Thus, targeted interventions to improve overall barrier function will be important disease prevention strategies for healthy aging in the future. |
format | Online Article Text |
id | pubmed-8912763 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-89127632022-03-11 The Intestinal Barrier Dysfunction as Driving Factor of Inflammaging Untersmayr, Eva Brandt, Annette Koidl, Larissa Bergheim, Ina Nutrients Review The intestinal barrier, composed of the luminal microbiota, the mucus layer, and the physical barrier consisting of epithelial cells and immune cells, the latter residing underneath and within the epithelial cells, plays a special role in health and disease. While there is growing knowledge on the changes to the different layers associated with disease development, the barrier function also plays an important role during aging. Besides changes in the composition and function of cellular junctions, the entire gastrointestinal physiology contributes to essential age-related changes. This is also reflected by substantial differences in the microbial composition throughout the life span. Even though it remains difficult to define physiological age-related changes and to distinguish them from early signs of pathologies, studies in centenarians provide insights into the intestinal barrier features associated with longevity. The knowledge reviewed in this narrative review article might contribute to the definition of strategies to prevent the development of diseases in the elderly. Thus, targeted interventions to improve overall barrier function will be important disease prevention strategies for healthy aging in the future. MDPI 2022-02-23 /pmc/articles/PMC8912763/ /pubmed/35267924 http://dx.doi.org/10.3390/nu14050949 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Untersmayr, Eva Brandt, Annette Koidl, Larissa Bergheim, Ina The Intestinal Barrier Dysfunction as Driving Factor of Inflammaging |
title | The Intestinal Barrier Dysfunction as Driving Factor of Inflammaging |
title_full | The Intestinal Barrier Dysfunction as Driving Factor of Inflammaging |
title_fullStr | The Intestinal Barrier Dysfunction as Driving Factor of Inflammaging |
title_full_unstemmed | The Intestinal Barrier Dysfunction as Driving Factor of Inflammaging |
title_short | The Intestinal Barrier Dysfunction as Driving Factor of Inflammaging |
title_sort | intestinal barrier dysfunction as driving factor of inflammaging |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8912763/ https://www.ncbi.nlm.nih.gov/pubmed/35267924 http://dx.doi.org/10.3390/nu14050949 |
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