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Oral Acid Load Down-Regulates Fibroblast Growth Factor 23

Increased dietary acid load has a negative impact on health, particularly when renal function is compromised. Fibroblast growth factor 23 (FGF23) is a bone-derived hormone that is elevated during renal failure. The relationship between metabolic acidosis and FGF23 remains unclear. To investigate the...

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Autores principales: Vidal, Angela, Pineda, Carmen, Raya, Ana I., Rios, Rafael, Espartero, Azahara, Muñoz-Castañeda, Juan R., Rodriguez, Mariano, Aguilera-Tejero, Escolastico, Lopez, Ignacio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8912769/
https://www.ncbi.nlm.nih.gov/pubmed/35268016
http://dx.doi.org/10.3390/nu14051041
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author Vidal, Angela
Pineda, Carmen
Raya, Ana I.
Rios, Rafael
Espartero, Azahara
Muñoz-Castañeda, Juan R.
Rodriguez, Mariano
Aguilera-Tejero, Escolastico
Lopez, Ignacio
author_facet Vidal, Angela
Pineda, Carmen
Raya, Ana I.
Rios, Rafael
Espartero, Azahara
Muñoz-Castañeda, Juan R.
Rodriguez, Mariano
Aguilera-Tejero, Escolastico
Lopez, Ignacio
author_sort Vidal, Angela
collection PubMed
description Increased dietary acid load has a negative impact on health, particularly when renal function is compromised. Fibroblast growth factor 23 (FGF23) is a bone-derived hormone that is elevated during renal failure. The relationship between metabolic acidosis and FGF23 remains unclear. To investigate the effect of dietary acid load on circulating levels of FGF23, rats with normal renal function and with a graded reduction in renal mass (1/2 Nx and 5/6 Nx) received oral NH(4)Cl for 1 month. Acid intake resulted in a consistent decrease of plasma FGF23 concentrations in all study groups when compared with their non-acidotic control: 239.3 ± 13.5 vs. 295.0 ± 15.8 pg/mL (intact), 346.4 ± 19.7 vs. 522.6 ± 29.3 pg/mL (1/2 Nx) and 988.0 ± 125.5 vs. 2549.4 ± 469.7 pg/mL (5/6 Nx). Acidosis also decreased plasma PTH in all groups, 96.5 ± 22.3 vs. 107.3 ± 19.1 pg/mL, 113.1 ± 17.3 vs. 185.8 ± 22.2 pg/mL and 504.9 ± 75.7 vs. 1255.4 ± 181.1 pg/mL. FGF23 showed a strong positive correlation with PTH (r = 0.877, p < 0.0001) and further studies demonstrated that acidosis did not influence plasma FGF23 concentrations in parathyroidectomized rats, 190.0 ± 31.6 vs. 215 ± 25.6 pg/mL. In conclusion, plasma concentrations of FGF23 are consistently decreased in rats with metabolic acidosis secondary to increased acid intake, both in animals with intact renal function and with decreased renal function. The in vivo effect of metabolic acidosis on FGF23 appears to be related to the simultaneous decrease in PTH.
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spelling pubmed-89127692022-03-11 Oral Acid Load Down-Regulates Fibroblast Growth Factor 23 Vidal, Angela Pineda, Carmen Raya, Ana I. Rios, Rafael Espartero, Azahara Muñoz-Castañeda, Juan R. Rodriguez, Mariano Aguilera-Tejero, Escolastico Lopez, Ignacio Nutrients Article Increased dietary acid load has a negative impact on health, particularly when renal function is compromised. Fibroblast growth factor 23 (FGF23) is a bone-derived hormone that is elevated during renal failure. The relationship between metabolic acidosis and FGF23 remains unclear. To investigate the effect of dietary acid load on circulating levels of FGF23, rats with normal renal function and with a graded reduction in renal mass (1/2 Nx and 5/6 Nx) received oral NH(4)Cl for 1 month. Acid intake resulted in a consistent decrease of plasma FGF23 concentrations in all study groups when compared with their non-acidotic control: 239.3 ± 13.5 vs. 295.0 ± 15.8 pg/mL (intact), 346.4 ± 19.7 vs. 522.6 ± 29.3 pg/mL (1/2 Nx) and 988.0 ± 125.5 vs. 2549.4 ± 469.7 pg/mL (5/6 Nx). Acidosis also decreased plasma PTH in all groups, 96.5 ± 22.3 vs. 107.3 ± 19.1 pg/mL, 113.1 ± 17.3 vs. 185.8 ± 22.2 pg/mL and 504.9 ± 75.7 vs. 1255.4 ± 181.1 pg/mL. FGF23 showed a strong positive correlation with PTH (r = 0.877, p < 0.0001) and further studies demonstrated that acidosis did not influence plasma FGF23 concentrations in parathyroidectomized rats, 190.0 ± 31.6 vs. 215 ± 25.6 pg/mL. In conclusion, plasma concentrations of FGF23 are consistently decreased in rats with metabolic acidosis secondary to increased acid intake, both in animals with intact renal function and with decreased renal function. The in vivo effect of metabolic acidosis on FGF23 appears to be related to the simultaneous decrease in PTH. MDPI 2022-02-28 /pmc/articles/PMC8912769/ /pubmed/35268016 http://dx.doi.org/10.3390/nu14051041 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Vidal, Angela
Pineda, Carmen
Raya, Ana I.
Rios, Rafael
Espartero, Azahara
Muñoz-Castañeda, Juan R.
Rodriguez, Mariano
Aguilera-Tejero, Escolastico
Lopez, Ignacio
Oral Acid Load Down-Regulates Fibroblast Growth Factor 23
title Oral Acid Load Down-Regulates Fibroblast Growth Factor 23
title_full Oral Acid Load Down-Regulates Fibroblast Growth Factor 23
title_fullStr Oral Acid Load Down-Regulates Fibroblast Growth Factor 23
title_full_unstemmed Oral Acid Load Down-Regulates Fibroblast Growth Factor 23
title_short Oral Acid Load Down-Regulates Fibroblast Growth Factor 23
title_sort oral acid load down-regulates fibroblast growth factor 23
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8912769/
https://www.ncbi.nlm.nih.gov/pubmed/35268016
http://dx.doi.org/10.3390/nu14051041
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