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Altered Serum Acylcarnitines Profile after a Prolonged Stay in Intensive Care

A stay in intensive care unit (ICU) exposes patients to a risk of carnitine deficiency. Moreover, acylated derivates of carnitine (acylcarnitines, AC) are biomarkers for metabolic mitochondrial dysfunction that have been linked to post-ICU disorders. This study aimed to describe the AC profile of su...

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Autores principales: Rousseau, Anne-Françoise, Schmitz, Sarah, Cavalier, Etienne, Misset, Benoit, Boemer, François
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8912811/
https://www.ncbi.nlm.nih.gov/pubmed/35268097
http://dx.doi.org/10.3390/nu14051122
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author Rousseau, Anne-Françoise
Schmitz, Sarah
Cavalier, Etienne
Misset, Benoit
Boemer, François
author_facet Rousseau, Anne-Françoise
Schmitz, Sarah
Cavalier, Etienne
Misset, Benoit
Boemer, François
author_sort Rousseau, Anne-Françoise
collection PubMed
description A stay in intensive care unit (ICU) exposes patients to a risk of carnitine deficiency. Moreover, acylated derivates of carnitine (acylcarnitines, AC) are biomarkers for metabolic mitochondrial dysfunction that have been linked to post-ICU disorders. This study aimed to describe the AC profile of survivors of a prolonged ICU stay (≥7 days). Survivors enrolled in our post-ICU clinic between September 2020 and July 2021 were included. Blood analysis was routinely performed during the days after ICU discharge, focusing on metabolic markers and including AC profile. Serum AC concentrations were determined by LC-MS/MS and were compared to the reference ranges (RR) established from serum samples of 50 non-hospitalized Belgian adults aged from 18 to 81 years. A total 162 patients (65.4% males, age 67 (58.7–73) years) survived an ICU stay of 9.7 (7.1–19.3) days and were evaluated 5 (3–8) days after discharge. Their AC profile was significantly different compared to RR, mostly in terms of short chain AC: the sum of C3, C4 and C5 derivates reached 1.36 (0.98–1.99) and 0.86 (0.66–0.99) µmol/L respectively (p < 0.001). Free carnitine (C0) concentration of survivors (46.06 (35.04–56.35) µmol/L) was similar to RR (43.64 (36.43–52.96) µmol/L) (p = 0.55). C0 below percentile 2.5 of RR was observed in 6/162 (3.7%) survivors. Their total AC/C0 ratio was 0.33 (0.22–0.42). A ratio above 0.4 was observed in 45/162 (27.8%) patients. In ICU survivors, carnitine deficiency was rare, but AC profile was altered and AC/C0 ratio was abnormal in more than 25%. The value of AC profile as a marker of post-ICU dysmetabolism needs further investigations.
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spelling pubmed-89128112022-03-11 Altered Serum Acylcarnitines Profile after a Prolonged Stay in Intensive Care Rousseau, Anne-Françoise Schmitz, Sarah Cavalier, Etienne Misset, Benoit Boemer, François Nutrients Article A stay in intensive care unit (ICU) exposes patients to a risk of carnitine deficiency. Moreover, acylated derivates of carnitine (acylcarnitines, AC) are biomarkers for metabolic mitochondrial dysfunction that have been linked to post-ICU disorders. This study aimed to describe the AC profile of survivors of a prolonged ICU stay (≥7 days). Survivors enrolled in our post-ICU clinic between September 2020 and July 2021 were included. Blood analysis was routinely performed during the days after ICU discharge, focusing on metabolic markers and including AC profile. Serum AC concentrations were determined by LC-MS/MS and were compared to the reference ranges (RR) established from serum samples of 50 non-hospitalized Belgian adults aged from 18 to 81 years. A total 162 patients (65.4% males, age 67 (58.7–73) years) survived an ICU stay of 9.7 (7.1–19.3) days and were evaluated 5 (3–8) days after discharge. Their AC profile was significantly different compared to RR, mostly in terms of short chain AC: the sum of C3, C4 and C5 derivates reached 1.36 (0.98–1.99) and 0.86 (0.66–0.99) µmol/L respectively (p < 0.001). Free carnitine (C0) concentration of survivors (46.06 (35.04–56.35) µmol/L) was similar to RR (43.64 (36.43–52.96) µmol/L) (p = 0.55). C0 below percentile 2.5 of RR was observed in 6/162 (3.7%) survivors. Their total AC/C0 ratio was 0.33 (0.22–0.42). A ratio above 0.4 was observed in 45/162 (27.8%) patients. In ICU survivors, carnitine deficiency was rare, but AC profile was altered and AC/C0 ratio was abnormal in more than 25%. The value of AC profile as a marker of post-ICU dysmetabolism needs further investigations. MDPI 2022-03-07 /pmc/articles/PMC8912811/ /pubmed/35268097 http://dx.doi.org/10.3390/nu14051122 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Rousseau, Anne-Françoise
Schmitz, Sarah
Cavalier, Etienne
Misset, Benoit
Boemer, François
Altered Serum Acylcarnitines Profile after a Prolonged Stay in Intensive Care
title Altered Serum Acylcarnitines Profile after a Prolonged Stay in Intensive Care
title_full Altered Serum Acylcarnitines Profile after a Prolonged Stay in Intensive Care
title_fullStr Altered Serum Acylcarnitines Profile after a Prolonged Stay in Intensive Care
title_full_unstemmed Altered Serum Acylcarnitines Profile after a Prolonged Stay in Intensive Care
title_short Altered Serum Acylcarnitines Profile after a Prolonged Stay in Intensive Care
title_sort altered serum acylcarnitines profile after a prolonged stay in intensive care
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8912811/
https://www.ncbi.nlm.nih.gov/pubmed/35268097
http://dx.doi.org/10.3390/nu14051122
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