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Parallel evolution of Pseudomonas aeruginosa phage resistance and virulence loss in response to phage treatment in vivo and in vitro
With rising antibiotic resistance, there has been increasing interest in treating pathogenic bacteria with bacteriophages (phage therapy). One limitation of phage therapy is the ease at which bacteria can evolve resistance. Negative effects of resistance may be mitigated when resistance results in r...
Autores principales: | Castledine, Meaghan, Padfield, Daniel, Sierocinski, Pawel, Soria Pascual, Jesica, Hughes, Adam, Mäkinen, Lotta, Friman, Ville-Petri, Pirnay, Jean-Paul, Merabishvili, Maya, de Vos, Daniel, Buckling, Angus |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8912922/ https://www.ncbi.nlm.nih.gov/pubmed/35188102 http://dx.doi.org/10.7554/eLife.73679 |
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