Augmentation of progestin signaling rescues testis organization and spermatogenesis in zebrafish with the depletion of androgen signaling

Disruption of androgen signaling is known to cause testicular malformation and defective spermatogenesis in zebrafish. However, knockout of cyp17a1, a key enzyme responsible for the androgen synthesis, in ar-/- male zebrafish paradoxically causes testicular hypertrophy and enhanced spermatogenesis....

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Detalles Bibliográficos
Autores principales: Zhai, Gang, Shu, Tingting, Yu, Guangqing, Tang, Haipei, Shi, Chuang, Jia, Jingyi, Lou, Qiyong, Dai, Xiangyan, Jin, Xia, He, Jiangyan, Xiao, Wuhan, Liu, Xiaochun, Yin, Zhan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8912926/
https://www.ncbi.nlm.nih.gov/pubmed/35225789
http://dx.doi.org/10.7554/eLife.66118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8912926/
https://www.ncbi.nlm.nih.gov/pubmed/35225789
http://dx.doi.org/10.7554/eLife.66118

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