Cargando…

Significance of Cardiac Troponins as an Identification Tool in COVID-19 Patients Using Biosensors: An Update

Coronavirus disease 2019 (COVID-19) has rapidly developed as a global health emergency. Respiratory diseases are significant causes of morbidity and mortality in these patients with a spectrum of different diseases, from asymptomatic subclinical infection to the progression of severe pneumonia and s...

Descripción completa

Detalles Bibliográficos
Autores principales: Rasmi, Yousef, Mosa, Osama F., Alipour, Shahriar, Heidari, Nadia, Javanmard, Farzaneh, Golchin, Ali, Gholizadeh-Ghaleh Aziz, Shiva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8912935/
https://www.ncbi.nlm.nih.gov/pubmed/35281265
http://dx.doi.org/10.3389/fmolb.2022.821155
_version_ 1784667291168800768
author Rasmi, Yousef
Mosa, Osama F.
Alipour, Shahriar
Heidari, Nadia
Javanmard, Farzaneh
Golchin, Ali
Gholizadeh-Ghaleh Aziz, Shiva
author_facet Rasmi, Yousef
Mosa, Osama F.
Alipour, Shahriar
Heidari, Nadia
Javanmard, Farzaneh
Golchin, Ali
Gholizadeh-Ghaleh Aziz, Shiva
author_sort Rasmi, Yousef
collection PubMed
description Coronavirus disease 2019 (COVID-19) has rapidly developed as a global health emergency. Respiratory diseases are significant causes of morbidity and mortality in these patients with a spectrum of different diseases, from asymptomatic subclinical infection to the progression of severe pneumonia and subsequent acute respiratory distress syndrome. Individuals with cardiovascular disease are more likely to become infected with SARS-CoV-2 and develop severe symptoms. Hence, patients with underlying cardiovascular disease mortality rate are over three times. Furthermore, note that patients with a history of cardiovascular disease are more likely to have higher cardiac biomarkers, especially cardiac troponins, than infected patients, especially those with severe disease, making these patients more susceptible to cardiac damage caused by SARS-2-CoV. Biomarkers are important in decision-making to facilitate the efficient allocation of resources. Viral replication in the heart muscle can lead to a cascade of inflammatory processes that lead to fibrosis and, ultimately, cardiac necrosis. Elevated troponin may indicate damage to the heart muscle and may predict death. After the first Chinese analysis, increased cardiac troponin value was observed in a significant proportion of patients, suggesting that myocardial damage is a possible pathogenic mechanism leading to severe disease and death. However, the prognostic performance of troponin and whether its value is affected by different comorbidities present in COVID-19 patients are not known. This review aimed to assess the diagnostic value of troponin to offer insight into pathophysiological mechanisms and reported new assessment methods, including new biosensors for troponin in patients with COVID-19.
format Online
Article
Text
id pubmed-8912935
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-89129352022-03-11 Significance of Cardiac Troponins as an Identification Tool in COVID-19 Patients Using Biosensors: An Update Rasmi, Yousef Mosa, Osama F. Alipour, Shahriar Heidari, Nadia Javanmard, Farzaneh Golchin, Ali Gholizadeh-Ghaleh Aziz, Shiva Front Mol Biosci Molecular Biosciences Coronavirus disease 2019 (COVID-19) has rapidly developed as a global health emergency. Respiratory diseases are significant causes of morbidity and mortality in these patients with a spectrum of different diseases, from asymptomatic subclinical infection to the progression of severe pneumonia and subsequent acute respiratory distress syndrome. Individuals with cardiovascular disease are more likely to become infected with SARS-CoV-2 and develop severe symptoms. Hence, patients with underlying cardiovascular disease mortality rate are over three times. Furthermore, note that patients with a history of cardiovascular disease are more likely to have higher cardiac biomarkers, especially cardiac troponins, than infected patients, especially those with severe disease, making these patients more susceptible to cardiac damage caused by SARS-2-CoV. Biomarkers are important in decision-making to facilitate the efficient allocation of resources. Viral replication in the heart muscle can lead to a cascade of inflammatory processes that lead to fibrosis and, ultimately, cardiac necrosis. Elevated troponin may indicate damage to the heart muscle and may predict death. After the first Chinese analysis, increased cardiac troponin value was observed in a significant proportion of patients, suggesting that myocardial damage is a possible pathogenic mechanism leading to severe disease and death. However, the prognostic performance of troponin and whether its value is affected by different comorbidities present in COVID-19 patients are not known. This review aimed to assess the diagnostic value of troponin to offer insight into pathophysiological mechanisms and reported new assessment methods, including new biosensors for troponin in patients with COVID-19. Frontiers Media S.A. 2022-02-24 /pmc/articles/PMC8912935/ /pubmed/35281265 http://dx.doi.org/10.3389/fmolb.2022.821155 Text en Copyright © 2022 Rasmi, Mosa, Alipour, Heidari, Javanmard, Golchin and Gholizadeh-Ghaleh Aziz. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Molecular Biosciences
Rasmi, Yousef
Mosa, Osama F.
Alipour, Shahriar
Heidari, Nadia
Javanmard, Farzaneh
Golchin, Ali
Gholizadeh-Ghaleh Aziz, Shiva
Significance of Cardiac Troponins as an Identification Tool in COVID-19 Patients Using Biosensors: An Update
title Significance of Cardiac Troponins as an Identification Tool in COVID-19 Patients Using Biosensors: An Update
title_full Significance of Cardiac Troponins as an Identification Tool in COVID-19 Patients Using Biosensors: An Update
title_fullStr Significance of Cardiac Troponins as an Identification Tool in COVID-19 Patients Using Biosensors: An Update
title_full_unstemmed Significance of Cardiac Troponins as an Identification Tool in COVID-19 Patients Using Biosensors: An Update
title_short Significance of Cardiac Troponins as an Identification Tool in COVID-19 Patients Using Biosensors: An Update
title_sort significance of cardiac troponins as an identification tool in covid-19 patients using biosensors: an update
topic Molecular Biosciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8912935/
https://www.ncbi.nlm.nih.gov/pubmed/35281265
http://dx.doi.org/10.3389/fmolb.2022.821155
work_keys_str_mv AT rasmiyousef significanceofcardiactroponinsasanidentificationtoolincovid19patientsusingbiosensorsanupdate
AT mosaosamaf significanceofcardiactroponinsasanidentificationtoolincovid19patientsusingbiosensorsanupdate
AT alipourshahriar significanceofcardiactroponinsasanidentificationtoolincovid19patientsusingbiosensorsanupdate
AT heidarinadia significanceofcardiactroponinsasanidentificationtoolincovid19patientsusingbiosensorsanupdate
AT javanmardfarzaneh significanceofcardiactroponinsasanidentificationtoolincovid19patientsusingbiosensorsanupdate
AT golchinali significanceofcardiactroponinsasanidentificationtoolincovid19patientsusingbiosensorsanupdate
AT gholizadehghalehazizshiva significanceofcardiactroponinsasanidentificationtoolincovid19patientsusingbiosensorsanupdate