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Non-GCB Diffuse Large B-Cell Lymphoma With an Atypical Disease Course: A Case Report and Clinical Exome Analysis

Diffuse large B-cell lymphoma (DLBCL) is the most common lymphoid tumor among other non-Hodgkin lymphomas (30-40% of all cases). This type of lymphoma is characterized by significant differences in treatment response and the heterogeneity of clinical traits. Approximately 60% of patients are cured u...

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Autores principales: Tsygankova, Svetlana, Komova, Daria, Boulygina, Eugenia, Slobodova, Natalia, Sharko, Fedor, Rastorguev, Sergey, Gladysheva-Azgari, Maria, Koroleva, Daria, Smol’yaninova, Anna, Tatarnikova, Svetlana, Obuchova, Tatiana, Nedoluzhko, Artem, Gabeeva, Nelli, Zvonkov, Eugene
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elmer Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8913013/
https://www.ncbi.nlm.nih.gov/pubmed/35317330
http://dx.doi.org/10.14740/wjon1436
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author Tsygankova, Svetlana
Komova, Daria
Boulygina, Eugenia
Slobodova, Natalia
Sharko, Fedor
Rastorguev, Sergey
Gladysheva-Azgari, Maria
Koroleva, Daria
Smol’yaninova, Anna
Tatarnikova, Svetlana
Obuchova, Tatiana
Nedoluzhko, Artem
Gabeeva, Nelli
Zvonkov, Eugene
author_facet Tsygankova, Svetlana
Komova, Daria
Boulygina, Eugenia
Slobodova, Natalia
Sharko, Fedor
Rastorguev, Sergey
Gladysheva-Azgari, Maria
Koroleva, Daria
Smol’yaninova, Anna
Tatarnikova, Svetlana
Obuchova, Tatiana
Nedoluzhko, Artem
Gabeeva, Nelli
Zvonkov, Eugene
author_sort Tsygankova, Svetlana
collection PubMed
description Diffuse large B-cell lymphoma (DLBCL) is the most common lymphoid tumor among other non-Hodgkin lymphomas (30-40% of all cases). This type of lymphoma is characterized by significant differences in treatment response and the heterogeneity of clinical traits. Approximately 60% of patients are cured using standard chemotherapy (CT), while in 10-15% of cases, the tumor is characterized by an extremely aggressive course and resistance to even the most high-dose programs with autologous stem cell transplantation (auto-SCT). The activated B-cell (ABC) subtype of DLBCL is characterized by poor prognosis. Here, we describe a clinical case of diffuse ABC-DLBCL with an atypical disease course. Complete remission was achieved after four courses of CT, followed by autologous hematopoietic stem cell transplantation (auto-HSCT). However, early relapse occurred 2 months after the completion of treatment. According to the results of cytogenetic studies, significant chromosome breakdowns were observed. Exome sequencing allowed for the detection of several novel mutations that affect components of the NOTCH2 and NF-κB signaling pathways, a number of epigenetic regulators (KMT2D, CREBBP, EP300, ARID1A, MEF2B), as well as members of the immunoglobulin superfamily (CD58 and CD70). Whether these mutations were the result of therapy or were originally present in the lymphoid tumor remains unclear. Nevertheless, the introduction of genomic technologies into clinical practice is important for making a diagnosis and developing a DLBCL treatment regimen with the use of targeted drugs.
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spelling pubmed-89130132022-03-21 Non-GCB Diffuse Large B-Cell Lymphoma With an Atypical Disease Course: A Case Report and Clinical Exome Analysis Tsygankova, Svetlana Komova, Daria Boulygina, Eugenia Slobodova, Natalia Sharko, Fedor Rastorguev, Sergey Gladysheva-Azgari, Maria Koroleva, Daria Smol’yaninova, Anna Tatarnikova, Svetlana Obuchova, Tatiana Nedoluzhko, Artem Gabeeva, Nelli Zvonkov, Eugene World J Oncol Case Report Diffuse large B-cell lymphoma (DLBCL) is the most common lymphoid tumor among other non-Hodgkin lymphomas (30-40% of all cases). This type of lymphoma is characterized by significant differences in treatment response and the heterogeneity of clinical traits. Approximately 60% of patients are cured using standard chemotherapy (CT), while in 10-15% of cases, the tumor is characterized by an extremely aggressive course and resistance to even the most high-dose programs with autologous stem cell transplantation (auto-SCT). The activated B-cell (ABC) subtype of DLBCL is characterized by poor prognosis. Here, we describe a clinical case of diffuse ABC-DLBCL with an atypical disease course. Complete remission was achieved after four courses of CT, followed by autologous hematopoietic stem cell transplantation (auto-HSCT). However, early relapse occurred 2 months after the completion of treatment. According to the results of cytogenetic studies, significant chromosome breakdowns were observed. Exome sequencing allowed for the detection of several novel mutations that affect components of the NOTCH2 and NF-κB signaling pathways, a number of epigenetic regulators (KMT2D, CREBBP, EP300, ARID1A, MEF2B), as well as members of the immunoglobulin superfamily (CD58 and CD70). Whether these mutations were the result of therapy or were originally present in the lymphoid tumor remains unclear. Nevertheless, the introduction of genomic technologies into clinical practice is important for making a diagnosis and developing a DLBCL treatment regimen with the use of targeted drugs. Elmer Press 2022-02 2022-02-08 /pmc/articles/PMC8913013/ /pubmed/35317330 http://dx.doi.org/10.14740/wjon1436 Text en Copyright 2022, Tsygankova et al. https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution Non-Commercial 4.0 International License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Tsygankova, Svetlana
Komova, Daria
Boulygina, Eugenia
Slobodova, Natalia
Sharko, Fedor
Rastorguev, Sergey
Gladysheva-Azgari, Maria
Koroleva, Daria
Smol’yaninova, Anna
Tatarnikova, Svetlana
Obuchova, Tatiana
Nedoluzhko, Artem
Gabeeva, Nelli
Zvonkov, Eugene
Non-GCB Diffuse Large B-Cell Lymphoma With an Atypical Disease Course: A Case Report and Clinical Exome Analysis
title Non-GCB Diffuse Large B-Cell Lymphoma With an Atypical Disease Course: A Case Report and Clinical Exome Analysis
title_full Non-GCB Diffuse Large B-Cell Lymphoma With an Atypical Disease Course: A Case Report and Clinical Exome Analysis
title_fullStr Non-GCB Diffuse Large B-Cell Lymphoma With an Atypical Disease Course: A Case Report and Clinical Exome Analysis
title_full_unstemmed Non-GCB Diffuse Large B-Cell Lymphoma With an Atypical Disease Course: A Case Report and Clinical Exome Analysis
title_short Non-GCB Diffuse Large B-Cell Lymphoma With an Atypical Disease Course: A Case Report and Clinical Exome Analysis
title_sort non-gcb diffuse large b-cell lymphoma with an atypical disease course: a case report and clinical exome analysis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8913013/
https://www.ncbi.nlm.nih.gov/pubmed/35317330
http://dx.doi.org/10.14740/wjon1436
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