Cargando…
A case report of tumor lysis syndrome after stage-one ALPPS
RATIONALE: Tumor lysis syndrome is a potentially lethal condition caused by rapid cell death, releasing a high level of toxic cytokines. It is common in patients with hematological malignancy but rare in solid tumors. PATIENT CONCERNS: A 64-year-old patient presented to our unit with a 17.3-cm hepat...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8913076/ https://www.ncbi.nlm.nih.gov/pubmed/35451414 http://dx.doi.org/10.1097/MD.0000000000029040 |
_version_ | 1784667334557827072 |
---|---|
author | Cheung, Ho Hung She, Wong Hoi Yap, Desmond Y.H. Tsang, Simon H.Y. Cheung, Tan To |
author_facet | Cheung, Ho Hung She, Wong Hoi Yap, Desmond Y.H. Tsang, Simon H.Y. Cheung, Tan To |
author_sort | Cheung, Ho Hung |
collection | PubMed |
description | RATIONALE: Tumor lysis syndrome is a potentially lethal condition caused by rapid cell death, releasing a high level of toxic cytokines. It is common in patients with hematological malignancy but rare in solid tumors. PATIENT CONCERNS: A 64-year-old patient presented to our unit with a 17.3-cm hepatocellular carcinoma and marginal liver reserve. The first-stage operation of associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) was performed. DIAGNOSIS: The patient was found to be anuric with grossly deranged electrolytes after the first-stage operation. Tumor lysis syndrome was diagnosed. INTERVENTIONS: The patient was transferred to the intensive care unit for aggressive fluid administration and continuous venovenous hemofiltration for the management of tumor lysis syndrome. OUTCOMES: The patient recovered and then underwent the second-stage operation of ALPPS with extended right hepatectomy 8 days after the initial operation without any long-term sequelae. LESSONS: ALPPS is a relatively new technique in liver surgery, entailing an increased risk of tumor lysis syndrome due to an in situ tumor after the first-stage operation. Clinicians should have a high index of suspicion regarding this potentially lethal complication with prompt management. |
format | Online Article Text |
id | pubmed-8913076 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-89130762022-03-15 A case report of tumor lysis syndrome after stage-one ALPPS Cheung, Ho Hung She, Wong Hoi Yap, Desmond Y.H. Tsang, Simon H.Y. Cheung, Tan To Medicine (Baltimore) 4500 RATIONALE: Tumor lysis syndrome is a potentially lethal condition caused by rapid cell death, releasing a high level of toxic cytokines. It is common in patients with hematological malignancy but rare in solid tumors. PATIENT CONCERNS: A 64-year-old patient presented to our unit with a 17.3-cm hepatocellular carcinoma and marginal liver reserve. The first-stage operation of associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) was performed. DIAGNOSIS: The patient was found to be anuric with grossly deranged electrolytes after the first-stage operation. Tumor lysis syndrome was diagnosed. INTERVENTIONS: The patient was transferred to the intensive care unit for aggressive fluid administration and continuous venovenous hemofiltration for the management of tumor lysis syndrome. OUTCOMES: The patient recovered and then underwent the second-stage operation of ALPPS with extended right hepatectomy 8 days after the initial operation without any long-term sequelae. LESSONS: ALPPS is a relatively new technique in liver surgery, entailing an increased risk of tumor lysis syndrome due to an in situ tumor after the first-stage operation. Clinicians should have a high index of suspicion regarding this potentially lethal complication with prompt management. Lippincott Williams & Wilkins 2022-03-11 /pmc/articles/PMC8913076/ /pubmed/35451414 http://dx.doi.org/10.1097/MD.0000000000029040 Text en Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/) |
spellingShingle | 4500 Cheung, Ho Hung She, Wong Hoi Yap, Desmond Y.H. Tsang, Simon H.Y. Cheung, Tan To A case report of tumor lysis syndrome after stage-one ALPPS |
title | A case report of tumor lysis syndrome after stage-one ALPPS |
title_full | A case report of tumor lysis syndrome after stage-one ALPPS |
title_fullStr | A case report of tumor lysis syndrome after stage-one ALPPS |
title_full_unstemmed | A case report of tumor lysis syndrome after stage-one ALPPS |
title_short | A case report of tumor lysis syndrome after stage-one ALPPS |
title_sort | case report of tumor lysis syndrome after stage-one alpps |
topic | 4500 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8913076/ https://www.ncbi.nlm.nih.gov/pubmed/35451414 http://dx.doi.org/10.1097/MD.0000000000029040 |
work_keys_str_mv | AT cheunghohung acasereportoftumorlysissyndromeafterstageonealpps AT shewonghoi acasereportoftumorlysissyndromeafterstageonealpps AT yapdesmondyh acasereportoftumorlysissyndromeafterstageonealpps AT tsangsimonhy acasereportoftumorlysissyndromeafterstageonealpps AT cheungtanto acasereportoftumorlysissyndromeafterstageonealpps AT cheunghohung casereportoftumorlysissyndromeafterstageonealpps AT shewonghoi casereportoftumorlysissyndromeafterstageonealpps AT yapdesmondyh casereportoftumorlysissyndromeafterstageonealpps AT tsangsimonhy casereportoftumorlysissyndromeafterstageonealpps AT cheungtanto casereportoftumorlysissyndromeafterstageonealpps |