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Chaga mushroom-induced oxalate nephropathy that clinically manifested as nephrotic syndrome: A case report

RATIONALE: The Chaga mushroom (Hymenochaetaceae, Inonotus obliquus) is a fungus belonging to the Hymenochaetaceae family. It is parasitic on birch and other tree species. Chaga mushrooms are rich in various vitamins, minerals, and nutrients. Some people consider these mushrooms medicinal as they hav...

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Autores principales: Kwon, Ohyun, Kim, Yaerim, Paek, Jin Hyuk, Park, Woo Yeong, Han, Seungyeup, Sin, Hyungchan, Jin, Kyubok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8913114/
https://www.ncbi.nlm.nih.gov/pubmed/35451393
http://dx.doi.org/10.1097/MD.0000000000028997
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author Kwon, Ohyun
Kim, Yaerim
Paek, Jin Hyuk
Park, Woo Yeong
Han, Seungyeup
Sin, Hyungchan
Jin, Kyubok
author_facet Kwon, Ohyun
Kim, Yaerim
Paek, Jin Hyuk
Park, Woo Yeong
Han, Seungyeup
Sin, Hyungchan
Jin, Kyubok
author_sort Kwon, Ohyun
collection PubMed
description RATIONALE: The Chaga mushroom (Hymenochaetaceae, Inonotus obliquus) is a fungus belonging to the Hymenochaetaceae family. It is parasitic on birch and other tree species. Chaga mushrooms are rich in various vitamins, minerals, and nutrients. Some people consider these mushrooms medicinal as they have been reported to suppress cancer progression through anti-inflammatory and antioxidant effects. However, recent studies have reported that excessive ingestion of Chaga mushrooms can cause acute oxalate nephropathy. PATIENT CONCERNS: A 69-year-old man who ingested Chaga mushroom powder (10–15 g per day) and vitamin C (500 mg per day) for the past 3 months developed acute kidney injury (AKI) with the clinical manifestations of nephrotic syndrome (NS). DIAGNOSIS: Pathological findings showed focal acute tubular injury and the deposition of calcium oxalate crystals in the tubules. Light microscopy showed interstitial fibrosis and tubular atrophy, and electron microscopy showed the effacement of the foot processes in podocytes. Based on these results, the diagnosis was acute oxalate nephropathy accompanied by minimal change disease (MCD). INTERVENTIONS: The patient's kidney function did not improve with supportive care, such as hydration and blood pressure control. Thus, we recommended hemodialysis and the administration of a high dose of steroids (intravenous hydrocortisone 500 mg twice a day for 3 days and oral prednisolone at 1 mg/kg). OUTCOMES: The patient's kidney function recovered just 1 month after the start of treatment, and the MCD was completely remitted. LESSONS: In cases of AKI with an unknown cause, it is important to closely observe the patient's medication history, and it is recommended to perform kidney biopsy. Furthermore, this study showed that active dialysis and high-dose steroid treatment can restore kidney function in patients with AKI caused by acute oxalate nephropathy with MCD.
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spelling pubmed-89131142022-03-15 Chaga mushroom-induced oxalate nephropathy that clinically manifested as nephrotic syndrome: A case report Kwon, Ohyun Kim, Yaerim Paek, Jin Hyuk Park, Woo Yeong Han, Seungyeup Sin, Hyungchan Jin, Kyubok Medicine (Baltimore) 5200 RATIONALE: The Chaga mushroom (Hymenochaetaceae, Inonotus obliquus) is a fungus belonging to the Hymenochaetaceae family. It is parasitic on birch and other tree species. Chaga mushrooms are rich in various vitamins, minerals, and nutrients. Some people consider these mushrooms medicinal as they have been reported to suppress cancer progression through anti-inflammatory and antioxidant effects. However, recent studies have reported that excessive ingestion of Chaga mushrooms can cause acute oxalate nephropathy. PATIENT CONCERNS: A 69-year-old man who ingested Chaga mushroom powder (10–15 g per day) and vitamin C (500 mg per day) for the past 3 months developed acute kidney injury (AKI) with the clinical manifestations of nephrotic syndrome (NS). DIAGNOSIS: Pathological findings showed focal acute tubular injury and the deposition of calcium oxalate crystals in the tubules. Light microscopy showed interstitial fibrosis and tubular atrophy, and electron microscopy showed the effacement of the foot processes in podocytes. Based on these results, the diagnosis was acute oxalate nephropathy accompanied by minimal change disease (MCD). INTERVENTIONS: The patient's kidney function did not improve with supportive care, such as hydration and blood pressure control. Thus, we recommended hemodialysis and the administration of a high dose of steroids (intravenous hydrocortisone 500 mg twice a day for 3 days and oral prednisolone at 1 mg/kg). OUTCOMES: The patient's kidney function recovered just 1 month after the start of treatment, and the MCD was completely remitted. LESSONS: In cases of AKI with an unknown cause, it is important to closely observe the patient's medication history, and it is recommended to perform kidney biopsy. Furthermore, this study showed that active dialysis and high-dose steroid treatment can restore kidney function in patients with AKI caused by acute oxalate nephropathy with MCD. Lippincott Williams & Wilkins 2022-03-11 /pmc/articles/PMC8913114/ /pubmed/35451393 http://dx.doi.org/10.1097/MD.0000000000028997 Text en Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/)
spellingShingle 5200
Kwon, Ohyun
Kim, Yaerim
Paek, Jin Hyuk
Park, Woo Yeong
Han, Seungyeup
Sin, Hyungchan
Jin, Kyubok
Chaga mushroom-induced oxalate nephropathy that clinically manifested as nephrotic syndrome: A case report
title Chaga mushroom-induced oxalate nephropathy that clinically manifested as nephrotic syndrome: A case report
title_full Chaga mushroom-induced oxalate nephropathy that clinically manifested as nephrotic syndrome: A case report
title_fullStr Chaga mushroom-induced oxalate nephropathy that clinically manifested as nephrotic syndrome: A case report
title_full_unstemmed Chaga mushroom-induced oxalate nephropathy that clinically manifested as nephrotic syndrome: A case report
title_short Chaga mushroom-induced oxalate nephropathy that clinically manifested as nephrotic syndrome: A case report
title_sort chaga mushroom-induced oxalate nephropathy that clinically manifested as nephrotic syndrome: a case report
topic 5200
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8913114/
https://www.ncbi.nlm.nih.gov/pubmed/35451393
http://dx.doi.org/10.1097/MD.0000000000028997
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