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An insight into the recent developments in anti-infective potential of indole and associated hybrids()

Prevention, accurate diagnosis, and effective treatment of infections are the main challenges in the overall management of infectious diseases. The best example is the ongoing SARs-COV-2(COVID-19) pandemic; the entire world is extremely worried about at present. Interestingly, heterocyclic moieties...

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Autores principales: Mathada, Basavarajaiah Suliphuldevara, Somappa, Sasidhar B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8913251/
https://www.ncbi.nlm.nih.gov/pubmed/35291692
http://dx.doi.org/10.1016/j.molstruc.2022.132808
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author Mathada, Basavarajaiah Suliphuldevara
Somappa, Sasidhar B
author_facet Mathada, Basavarajaiah Suliphuldevara
Somappa, Sasidhar B
author_sort Mathada, Basavarajaiah Suliphuldevara
collection PubMed
description Prevention, accurate diagnosis, and effective treatment of infections are the main challenges in the overall management of infectious diseases. The best example is the ongoing SARs-COV-2(COVID-19) pandemic; the entire world is extremely worried about at present. Interestingly, heterocyclic moieties provide an ideal scaffold on which suitable pharmacophores can be designed to construct novel drugs. Indoles are amongst the most essential class of heteroaromatics in medicinal chemistry, which are ubiquitous across natural sources. The aforesaid derivatives have become invaluable scaffolds because of their wide spectrum therapeutic applications. Therefore, many researchers are focused on the design and synthesis of indole and associated hybrids of biological relevance. Hence, in the present review, we concisely discuss the indole containing natural sources, marketed drugs, clinical candidates, and their biological activities like antibacterial, antifungal, anti-TB, antiviral, antimalarial, and anti-leishmanial activities. The structure-activity relationships study of indole derivatives is also presented for a better understanding of the identified structures. The literature data presented for the anti-infective agents herein covers largely for the last twelve years.
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spelling pubmed-89132512022-03-11 An insight into the recent developments in anti-infective potential of indole and associated hybrids() Mathada, Basavarajaiah Suliphuldevara Somappa, Sasidhar B J Mol Struct Article Prevention, accurate diagnosis, and effective treatment of infections are the main challenges in the overall management of infectious diseases. The best example is the ongoing SARs-COV-2(COVID-19) pandemic; the entire world is extremely worried about at present. Interestingly, heterocyclic moieties provide an ideal scaffold on which suitable pharmacophores can be designed to construct novel drugs. Indoles are amongst the most essential class of heteroaromatics in medicinal chemistry, which are ubiquitous across natural sources. The aforesaid derivatives have become invaluable scaffolds because of their wide spectrum therapeutic applications. Therefore, many researchers are focused on the design and synthesis of indole and associated hybrids of biological relevance. Hence, in the present review, we concisely discuss the indole containing natural sources, marketed drugs, clinical candidates, and their biological activities like antibacterial, antifungal, anti-TB, antiviral, antimalarial, and anti-leishmanial activities. The structure-activity relationships study of indole derivatives is also presented for a better understanding of the identified structures. The literature data presented for the anti-infective agents herein covers largely for the last twelve years. Elsevier B.V. 2022-08-05 2022-03-11 /pmc/articles/PMC8913251/ /pubmed/35291692 http://dx.doi.org/10.1016/j.molstruc.2022.132808 Text en © 2022 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Mathada, Basavarajaiah Suliphuldevara
Somappa, Sasidhar B
An insight into the recent developments in anti-infective potential of indole and associated hybrids()
title An insight into the recent developments in anti-infective potential of indole and associated hybrids()
title_full An insight into the recent developments in anti-infective potential of indole and associated hybrids()
title_fullStr An insight into the recent developments in anti-infective potential of indole and associated hybrids()
title_full_unstemmed An insight into the recent developments in anti-infective potential of indole and associated hybrids()
title_short An insight into the recent developments in anti-infective potential of indole and associated hybrids()
title_sort insight into the recent developments in anti-infective potential of indole and associated hybrids()
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8913251/
https://www.ncbi.nlm.nih.gov/pubmed/35291692
http://dx.doi.org/10.1016/j.molstruc.2022.132808
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