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Tailor made: New insights into lipoarabinomannan structure may improve TB diagnosis
Detecting the mycobacterial glycolipid lipoarabinomannan (LAM) in urine by anti-LAM antibodies fills a gap in the diagnostic armamentarium of much needed simple rapid tests for tuberculosis, but lacks high sensitivity in all patient groups. A better understanding of LAM structure from clinically rel...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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American Society for Biochemistry and Molecular Biology
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8913296/ https://www.ncbi.nlm.nih.gov/pubmed/35122792 http://dx.doi.org/10.1016/j.jbc.2022.101678 |
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author | Lowary, Todd L. Achkar, Jacqueline M. |
author_facet | Lowary, Todd L. Achkar, Jacqueline M. |
author_sort | Lowary, Todd L. |
collection | PubMed |
description | Detecting the mycobacterial glycolipid lipoarabinomannan (LAM) in urine by anti-LAM antibodies fills a gap in the diagnostic armamentarium of much needed simple rapid tests for tuberculosis, but lacks high sensitivity in all patient groups. A better understanding of LAM structure from clinically relevant strains may allow improvements in diagnostic performance. De et al. have recently determined the structures of LAM from three epidemiologically important lineages of Mycobacterium tuberculosis and probed their interaction with an anti-LAM monoclonal antibody. Their results not only identify a series of tailoring modifications that impact antibody binding but also provide a roadmap for improving U-LAM-based diagnostics. |
format | Online Article Text |
id | pubmed-8913296 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | American Society for Biochemistry and Molecular Biology |
record_format | MEDLINE/PubMed |
spelling | pubmed-89132962022-03-18 Tailor made: New insights into lipoarabinomannan structure may improve TB diagnosis Lowary, Todd L. Achkar, Jacqueline M. J Biol Chem Editors' Pick Highlight Detecting the mycobacterial glycolipid lipoarabinomannan (LAM) in urine by anti-LAM antibodies fills a gap in the diagnostic armamentarium of much needed simple rapid tests for tuberculosis, but lacks high sensitivity in all patient groups. A better understanding of LAM structure from clinically relevant strains may allow improvements in diagnostic performance. De et al. have recently determined the structures of LAM from three epidemiologically important lineages of Mycobacterium tuberculosis and probed their interaction with an anti-LAM monoclonal antibody. Their results not only identify a series of tailoring modifications that impact antibody binding but also provide a roadmap for improving U-LAM-based diagnostics. American Society for Biochemistry and Molecular Biology 2022-02-02 /pmc/articles/PMC8913296/ /pubmed/35122792 http://dx.doi.org/10.1016/j.jbc.2022.101678 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Editors' Pick Highlight Lowary, Todd L. Achkar, Jacqueline M. Tailor made: New insights into lipoarabinomannan structure may improve TB diagnosis |
title | Tailor made: New insights into lipoarabinomannan structure may improve TB diagnosis |
title_full | Tailor made: New insights into lipoarabinomannan structure may improve TB diagnosis |
title_fullStr | Tailor made: New insights into lipoarabinomannan structure may improve TB diagnosis |
title_full_unstemmed | Tailor made: New insights into lipoarabinomannan structure may improve TB diagnosis |
title_short | Tailor made: New insights into lipoarabinomannan structure may improve TB diagnosis |
title_sort | tailor made: new insights into lipoarabinomannan structure may improve tb diagnosis |
topic | Editors' Pick Highlight |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8913296/ https://www.ncbi.nlm.nih.gov/pubmed/35122792 http://dx.doi.org/10.1016/j.jbc.2022.101678 |
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