Structural insights into how GlcNAc-1-phosphotransferase directs lysosomal protein transport

GlcNAc-1-phosphotransferase catalyzes the initial step in the formation of the mannose-6-phosphate tag that labels ∼60 lysosomal proteins for transport. Mutations in GlcNAc-1-phosphotransferase are known to cause lysosomal storage disorders such as mucolipidoses. However, the molecular mechanism of...

Descripción completa

Detalles Bibliográficos
Autores principales: Du, Shuo, Wang, Guopeng, Zhang, Zhiying, Ma, Chengying, Gao, Ning, Xiao, Junyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8913297/
https://www.ncbi.nlm.nih.gov/pubmed/35148990
http://dx.doi.org/10.1016/j.jbc.2022.101702

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8913297/
https://www.ncbi.nlm.nih.gov/pubmed/35148990
http://dx.doi.org/10.1016/j.jbc.2022.101702

Ejemplares similares