Two distinct classes of cochaperones compete for the EEVD motif in heat shock protein 70 to tune its chaperone activities

Chaperones of the heat shock protein 70 (Hsp70) family engage in protein–protein interactions with many cochaperones. One “hotspot” for cochaperone binding is the EEVD motif, found at the extreme C terminus of cytoplasmic Hsp70s. This motif is known to bind tetratricopeptide repeat domain cochaperon...

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Detalles Bibliográficos
Autores principales: Johnson, Oleta T., Nadel, Cory M., Carroll, Emma C., Arhar, Taylor, Gestwicki, Jason E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8913300/
https://www.ncbi.nlm.nih.gov/pubmed/35148989
http://dx.doi.org/10.1016/j.jbc.2022.101697

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